Sporadic pheochromocytoma/secreting paraganglioma
diseaseOn this page
Summary
Sporadic pheochromocytoma/secreting paraganglioma (MONDO:0017190) is a disease. A subtype of paraganglioma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide) [Orphanet-validated]
- Phenotypes (HPO): 36
Clinical features
Signs & symptoms
Clinical features (HPO)
36 HPO clinical features (Orphanet curated; top 36 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0002668 | Paraganglioma | Very frequent (80-99%) |
| HP:0006737 | Extraadrenal pheochromocytoma | Very frequent (80-99%) |
| HP:0006748 | Adrenal pheochromocytoma | Very frequent (80-99%) |
| HP:0000093 | Proteinuria | Frequent (30-79%) |
| HP:0000096 | Glomerulosclerosis | Frequent (30-79%) |
| HP:0000740 | Episodic paroxysmal anxiety | Frequent (30-79%) |
| HP:0001069 | Episodic hyperhidrosis | Frequent (30-79%) |
| HP:0001095 | Hypertensive retinopathy | Frequent (30-79%) |
| HP:0001342 | Cerebral hemorrhage | Frequent (30-79%) |
| HP:0001618 | Dysphonia | Frequent (30-79%) |
| HP:0001824 | Weight loss | Frequent (30-79%) |
| HP:0001962 | Palpitations | Frequent (30-79%) |
| HP:0002018 | Nausea | Frequent (30-79%) |
| HP:0002331 | Recurrent paroxysmal headache | Frequent (30-79%) |
| HP:0002574 | Episodic abdominal pain | Frequent (30-79%) |
| HP:0002640 | Hypertension associated with pheochromocytoma | Frequent (30-79%) |
| HP:0002864 | Paraganglioma of head and neck | Frequent (30-79%) |
| HP:0003072 | Hypercalcemia | Frequent (30-79%) |
| HP:0003345 | Elevated urinary norepinephrine | Frequent (30-79%) |
| HP:0003574 | Positive regitine blocking test | Frequent (30-79%) |
| HP:0003639 | Elevated urinary epinephrine | Frequent (30-79%) |
| HP:0008629 | Pulsatile tinnitus | Frequent (30-79%) |
| HP:0010532 | Paroxysmal vertigo | Frequent (30-79%) |
| HP:0011703 | Sinus tachycardia | Frequent (30-79%) |
| HP:0011979 | Elevated urinary dopamine | Frequent (30-79%) |
| HP:0012378 | Fatigue | Frequent (30-79%) |
| HP:0031284 | Flushing | Frequent (30-79%) |
| HP:0100749 | Chest pain | Frequent (30-79%) |
| HP:0000405 | Conductive hearing impairment | Occasional (5-29%) |
| HP:0000790 | Hematuria | Occasional (5-29%) |
| HP:0000980 | Pallor | Occasional (5-29%) |
| HP:0001293 | Cranial nerve compression | Occasional (5-29%) |
| HP:0001337 | Tremor | Occasional (5-29%) |
| HP:0001605 | Vocal cord paralysis | Occasional (5-29%) |
| HP:0001635 | Congestive heart failure | Occasional (5-29%) |
| HP:0025269 | Panic attack | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | sporadic pheochromocytoma/secreting paraganglioma |
| Mondo ID | MONDO:0017190 |
| Orphanet | 276621 |
| UMLS | C4707333 |
| MedGen | 1636854 |
| GARD | 0007385 |
| Is cancer (heuristic) | no |
Data availability: 5 cell lines.
Disease family
This is a subtype of paraganglioma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › autonomic nervous system disorder › autonomic nervous system neoplasm › paraganglioma › sporadic pheochromocytoma/secreting paraganglioma
Related subtypes (11): head and neck paraganglioma, pheochromocytoma/paraganglioma syndrome 4, pheochromocytoma/paraganglioma syndrome 1, pheochromocytoma/paraganglioma syndrome 2, pheochromocytoma/paraganglioma syndrome 3, pheochromocytoma/paraganglioma syndrome 5, non-secreting paraganglioma, parasympathetic paraganglioma, sympathetic paraganglioma, pheochromocytoma/paraganglioma syndrome 6, pheochromocytoma/paraganglioma syndrome 7
Subtypes (3): sporadic pheochromocytoma, sporadic secreting paraganglioma, multiple paragangliomas associated with polycythemia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.