Squamous carcinoma in situ

Summary

Squamous carcinoma in situ (MONDO:0004693) is a cancer and 8 clinical trials. Top therapeutic interventions include calcipotriene and fluorouracil. A subtype of in situ carcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 8

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	squamous carcinoma in situ
Mondo ID	MONDO:0004693
NCIT	C27093
UMLS	C0334245
MedGen	83116
Is cancer (heuristic)	yes

Also known as: carcinoma in situ of cervix · carcinoma in situ of uterine cervix · carcinoma, squamous cell, in situ, malignant · cervical intraepithelial neoplasia grade III with severe dysplasia · cervix Ca in situ · CIN III · CIN III - carcinoma in situ of cervix · CIN III - severe dyskaryosis · epidermoid carcinoma in situ · epidermoid cell carcinoma in situ · grade 3 SIN · grade 3 squamous intraepithelial neoplasia · grade III SIN · grade III squamous intraepithelial neoplasia · intraepithelial squamous cell carcinoma · severe dysplasia of cervix · severe dysplasia of the cervix uteri · squamous carcinoma in situ · squamous cell carcinoma in situ · squamous cell carcinoma in-situ (+4 more)

Disease family

This is a subtype of in situ carcinoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › carcinoma › in situ carcinoma › squamous carcinoma in situ

Related subtypes (20): oral cavity carcinoma in situ, pharynx carcinoma in situ, gall bladder carcinoma in situ, adenocarcinoma in situ, nasal cavity carcinoma in situ, skin carcinoma in situ, breast carcinoma in situ, eye carcinoma in situ, lung carcinoma in situ, larynx carcinoma in situ, intestine carcinoma in situ, bladder carcinoma in situ, esophagus carcinoma in situ, uterus carcinoma in situ, liver carcinoma in situ, stomach carcinoma in situ, kidney carcinoma in situ, grade III prostatic intraepithelial neoplasia, carcinoma in situ of ureter, carcinoma in situ of urethra

Subtypes (3): trachea carcinoma in situ, penis carcinoma in situ, skin squamous cell carcinoma in situ

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 8.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	5
PHASE4	1
PHASE2/PHASE3	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00868088	PHASE4	COMPLETED	Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip
NCT05381597	PHASE2/PHASE3	RECRUITING	5-Fluorouracil and Calcipotriene for Treatment of Low Grade Skin Cancer
NCT04844983	PHASE2	COMPLETED	A Study to Evaluate Safety, Efficacy of Intralesional Injection of STP705 in Patients With isSCC
NCT01245972	Not specified	COMPLETED	Pilot Study of PDL to Treat BCC and SCCIS
NCT02002468	Not specified	UNKNOWN	Follow-up of Abnormal and Inadequate Smear-test Results
NCT02124252	Not specified	COMPLETED	Community-Driven Cervical Cancer Prevention in Western Kenya
NCT02406352	Not specified	UNKNOWN	Multispectral Digital Colposcope With Probe for Detection of Cervical Intraepithelial Neoplasia
NCT04695015	Not specified	UNKNOWN	Research of Pathological Imaging Diagnosis of Ocular Tumors Based on New Artificial Intelligence Algorithm

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CALCIPOTRIENE	4	1
FLUOROURACIL	4	1