Squamous cell carcinoma of gallbladder and extrahepatic biliary tract

Summary

Squamous cell carcinoma of gallbladder and extrahepatic biliary tract (MONDO:0018537) is a cancer. A subtype of extrahepatic bile duct squamous cell carcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Prevalence: <1 / 1 000 000 (Europe) [Orphanet-validated]

Clinical features

Epidemiology

Prevalence records

23 prevalence record(s), Orphanet, top 20 (validated / broadest geography first):

Type	Class	Value	Geography	Validation
Annual incidence	<1 / 1 000 000	0.032	Europe	Validated
Annual incidence	<1 / 1 000 000	0.026	Austria	Validated
Annual incidence	<1 / 1 000 000	0.006	Belgium	Validated
Annual incidence	<1 / 1 000 000	0.027	Bulgaria	Validated
Annual incidence	<1 / 1 000 000	0.025	Croatia	Validated
Annual incidence	1-9 / 1 000 000	0.124	Czech Republic	Validated
Annual incidence	<1 / 1 000 000	0.037	Estonia	Validated
Annual incidence	<1 / 1 000 000	0.026	Finland	Validated
Annual incidence	<1 / 1 000 000	0.018	France	Validated
Annual incidence	<1 / 1 000 000	0.055	Germany	Validated
Annual incidence	<1 / 1 000 000	0.043	Iceland	Validated
Annual incidence	<1 / 1 000 000	0.018	Ireland	Validated
Annual incidence	<1 / 1 000 000	0.037	Italy	Validated
Annual incidence	<1 / 1 000 000	0.005	Latvia	Validated
Annual incidence	<1 / 1 000 000	0.033	Lithuania	Validated
Annual incidence	<1 / 1 000 000	0.016	Norway	Validated
Annual incidence	<1 / 1 000 000	0.015	Poland	Validated
Annual incidence	<1 / 1 000 000	0.002	Portugal	Validated
Annual incidence	<1 / 1 000 000	0.077	Slovakia	Validated
Annual incidence	<1 / 1 000 000	0.042	Spain	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	squamous cell carcinoma of gallbladder and extrahepatic biliary tract
Mondo ID	MONDO:0018537
Orphanet	424996
SNOMED CT	766978002
UMLS	C4707898
MedGen	1635098
GARD	0021792
Is cancer (heuristic)	yes

Also known as: squamous cell carcinoma of gallblader and EBT

Disease family

Classification path: human disease › disease by body system or component › digestive system disorder › digestive system cancer › liver cancer › biliary tract cancer › bile duct cancer › bile duct carcinoma › extrahepatic bile duct carcinoma › extrahepatic bile duct squamous cell carcinoma › squamous cell carcinoma of gallbladder and extrahepatic biliary tract

Related subtypes (2): ampulla of vater squamous cell carcinoma, extrahepatic bile duct adenosquamous carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.