Squamous cell carcinoma of pancreas

Summary

Squamous cell carcinoma of pancreas (MONDO:0018521) is a cancer and 3 clinical trials. Top therapeutic interventions include cisplatin, domvanalimab, and zimberelimab. A subtype of squamous cell carcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Prevalence: <1 / 1 000 000 (Europe) [Orphanet-validated]
• Clinical trials: 3

Clinical features

Epidemiology

Prevalence records

22 prevalence record(s), Orphanet, top 20 (validated / broadest geography first):

Type	Class	Value	Geography	Validation
Annual incidence	<1 / 1 000 000	0.023	Europe	Validated
Annual incidence	<1 / 1 000 000	0.044	Austria	Validated
Annual incidence	<1 / 1 000 000	0.006	Belgium	Validated
Annual incidence	<1 / 1 000 000	0.027	Bulgaria	Validated
Annual incidence	<1 / 1 000 000	0.028	Croatia	Validated
Annual incidence	<1 / 1 000 000	0.045	Czech Republic	Validated
Annual incidence	<1 / 1 000 000	0.028	Estonia	Validated
Annual incidence	<1 / 1 000 000	0.012	Finland	Validated
Annual incidence	<1 / 1 000 000	0.015	France	Validated
Annual incidence	<1 / 1 000 000	0.032	Germany	Validated
Annual incidence	<1 / 1 000 000	0.034	Ireland	Validated
Annual incidence	<1 / 1 000 000	0.019	Italy	Validated
Annual incidence	<1 / 1 000 000	0.06	Latvia	Validated
Annual incidence	<1 / 1 000 000	0.058	Lithuania	Validated
Annual incidence	<1 / 1 000 000	0.003	Norway	Validated
Annual incidence	<1 / 1 000 000	0.008	Poland	Validated
Annual incidence	<1 / 1 000 000	0.016	Portugal	Validated
Annual incidence	<1 / 1 000 000	0.005	Slovakia	Validated
Annual incidence	<1 / 1 000 000	0.027	Spain	Validated
Annual incidence	<1 / 1 000 000	0.006	Switzerland	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	squamous cell carcinoma of pancreas
Mondo ID	MONDO:0018521
Orphanet	424039
DOID	DOID:0080323
NCIT	C173813
UMLS	C2675993
MedGen	393937
GARD	0021776
Anatomy (UBERON)	UBERON:0001264
Is cancer (heuristic)	yes

Also known as: pancreas squamous cell carcinoma · pancreatic squamous cell carcinoma

Data availability: 20 cell lines.

Disease family

This is a subtype of squamous cell carcinoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › epithelial neoplasm › squamous cell neoplasm › squamous cell carcinoma › squamous cell carcinoma of pancreas

Related subtypes (38): bone squamous cell carcinoma, prostate squamous cell carcinoma, trachea squamous cell carcinoma, scrotum squamous cell carcinoma, skin squamous cell carcinoma, bladder squamous cell carcinoma, urethra squamous cell carcinoma, papillary squamous carcinoma, basaloid squamous cell carcinoma, pseudoglandular squamous cell carcinoma, thymus squamous cell carcinoma, ovarian squamous cell carcinoma, renal pelvis squamous cell carcinoma, ureter squamous cell carcinoma, fallopian tube squamous cell carcinoma, squamous carcinoma in situ, keratinizing squamous cell carcinoma, squamous cell lung carcinoma, esophageal squamous cell carcinoma, squamous cell breast carcinoma, adenosquamous carcinoma, cervical squamous cell carcinoma, colorectal squamous cell carcinoma, endometrial squamous cell carcinoma, gallbladder squamous cell carcinoma, gastric squamous cell carcinoma, thyroid gland squamous cell carcinoma, vaginal squamous cell carcinoma, head and neck squamous cell carcinoma, squamous cell carcinoma of the corpus uteri, squamous cell carcinoma of penis, squamous cell carcinoma of the small intestine, squamous cell carcinoma of liver and intrahepatic biliary tract, human papillomavirus-related squamous cell carcinoma, sarcomatoid squamous cell carcinoma, vulvar squamous cell carcinoma, metastatic squamous cell carcinoma, pure squamous carcinoma of the urothelial tract

Subtypes (1): pancreatic adenosquamous carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2/PHASE3	1
PHASE2	1
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06115499	PHASE2/PHASE3	ACTIVE_NOT_RECRUITING	The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer
NCT04858334	PHASE2	RECRUITING	APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
NCT05419479	PHASE1/PHASE2	SUSPENDED	Switch Maintenance in Pancreatic

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CISPLATIN	4	1
DOMVANALIMAB	3	1
ZIMBERELIMAB	3	1
SOTIGALIMAB	2	1