Squamous cell carcinoma of rectum

Summary

Squamous cell carcinoma of rectum (MONDO:0018515) is a cancer and 2 clinical trials. Top therapeutic interventions include fludeoxyglucose f 18 and mitomycin. A subtype of colorectal squamous cell carcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Prevalence: 1-9 / 1 000 000 (Europe) [Orphanet-validated]
• Clinical trials: 2

Clinical features

Epidemiology

Prevalence records

23 prevalence record(s), Orphanet, top 20 (validated / broadest geography first):

Type	Class	Value	Geography	Validation
Annual incidence	1-9 / 1 000 000	0.113	Europe	Validated
Annual incidence	1-9 / 1 000 000	0.126	Austria	Validated
Annual incidence	<1 / 1 000 000	0.052	Belgium	Validated
Annual incidence	<1 / 1 000 000	0.088	Bulgaria	Validated
Annual incidence	<1 / 1 000 000	0.017	Croatia	Validated
Annual incidence	1-9 / 1 000 000	0.26	Czech Republic	Validated
Annual incidence	1-9 / 1 000 000	0.157	Estonia	Validated
Annual incidence	<1 / 1 000 000	0.045	Finland	Validated
Annual incidence	<1 / 1 000 000	0.074	France	Validated
Annual incidence	<1 / 1 000 000	0.083	Germany	Validated
Annual incidence	1-9 / 1 000 000	0.128	Iceland	Validated
Annual incidence	<1 / 1 000 000	0.096	Ireland	Validated
Annual incidence	1-9 / 1 000 000	0.149	Italy	Validated
Annual incidence	1-9 / 1 000 000	0.346	Latvia	Validated
Annual incidence	1-9 / 1 000 000	0.116	Lithuania	Validated
Annual incidence	<1 / 1 000 000	0.071	Norway	Validated
Annual incidence	1-9 / 1 000 000	0.111	Poland	Validated
Annual incidence	1-9 / 1 000 000	0.119	Portugal	Validated
Annual incidence	<1 / 1 000 000	0.05	Slovakia	Validated
Annual incidence	<1 / 1 000 000	0.042	Spain	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	squamous cell carcinoma of rectum
Mondo ID	MONDO:0018515
Orphanet	424002
DOID	DOID:5528
NCIT	C5554
SNOMED CT	766979005
UMLS	C1335690
MedGen	235534
GARD	0021770
Anatomy (UBERON)	UBERON:0001052
Is cancer (heuristic)	yes

Also known as: rectal squamous carcinoma · rectal squamous cell cancer · rectal squamous cell carcinoma · rectum squamous cell carcinoma · squamous carcinoma of rectum · squamous carcinoma of the rectum · squamous cell carcinoma of rectum · squamous cell carcinoma of the rectum

Disease family

This is a subtype of colorectal squamous cell carcinoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › epithelial neoplasm › squamous cell neoplasm › squamous cell carcinoma › colorectal squamous cell carcinoma › squamous cell carcinoma of rectum

Related subtypes (2): colorectal adenosquamous carcinoma, squamous cell carcinoma of colon

Subtypes (3): rectal cloacogenic carcinoma, anal squamous cell carcinoma, rectal adenosquamous carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04929028	PHASE2	ACTIVE_NOT_RECRUITING	Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer
NCT06364384	PHASE2	RECRUITING	Radical Concurrent Chemoradiotherapy With DDP/5-FU and PD-1 Antibody for Non-metastatic Rectal Squamous Cell Carcinoma

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
FLUDEOXYGLUCOSE F 18	4	1
MITOMYCIN	4	1