Squamous cell intraepithelial neoplasia

Summary

Squamous cell intraepithelial neoplasia (MONDO:0024475) is a disease and 2 clinical trials. A subtype of squamous cell neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 2

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	squamous cell intraepithelial neoplasia
Mondo ID	MONDO:0024475
NCIT	C8334
UMLS	C0333873
MedGen	83092
Is cancer (heuristic)	no

Also known as: sil · SIN · squamous cell intraepithelial neoplasia · squamous intraepithelial lesion

Disease family

An umbrella term covering 3 Mondo subtypes.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › epithelial neoplasm › squamous cell neoplasm › squamous cell intraepithelial neoplasia

Related subtypes (6): vaginal squamous tumor, vulvar squamous neoplasm, ovarian squamous cell neoplasm, squamous cell carcinoma, craniopharyngioma, ocular surface squamous neoplasia

Subtypes (3): conjunctival intraepithelial neoplasm, corneal intraepithelial neoplasm, cervical squamous intraepithelial neoplasia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07029152	Not specified	RECRUITING	Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure Prophylaxis
NCT05170620	Not specified	UNKNOWN	Research of Laser Ablation for the Treatment of Lower Anogenital Tracts’ Precancerous Lesions