Staphylococcal necrotizing pneumonia

Summary

Staphylococcal necrotizing pneumonia (MONDO:0018183) is a disease. A subtype of respiratory system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 38

Clinical features

Signs & symptoms

Clinical features (HPO)

38 HPO clinical features (Orphanet curated; top 38 by frequency):

HPO ID	Term	Frequency
HP:0001945	Fever	Very frequent (80-99%)
HP:0001974	Leukocytosis	Very frequent (80-99%)
HP:0002090	Pneumonia	Very frequent (80-99%)
HP:0002094	Dyspnea	Very frequent (80-99%)
HP:0002098	Respiratory distress	Very frequent (80-99%)
HP:0002789	Tachypnea	Very frequent (80-99%)
HP:0003565	Elevated erythrocyte sedimentation rate	Very frequent (80-99%)
HP:0012735	Cough	Very frequent (80-99%)
HP:0032169	Severe infection	Very frequent (80-99%)
HP:0012418	Hypoxemia	Frequent (30-79%)
HP:0031246	Nonproductive cough	Frequent (30-79%)
HP:0031864	Bacteremia	Frequent (30-79%)
HP:0032177	Parenchymal consolidation	Frequent (30-79%)
HP:0032308	Increased circulating procalcitonin concentration	Frequent (30-79%)
HP:0100749	Chest pain	Frequent (30-79%)
HP:0002202	Pleural effusion	Frequent (30-79%)
HP:0002615	Hypotension	Frequent (30-79%)
HP:0002878	Respiratory failure	Frequent (30-79%)
HP:0011227	Elevated circulating C-reactive protein concentration	Frequent (30-79%)
HP:0011897	Neutrophilia	Frequent (30-79%)
HP:0011919	Pleural empyema	Frequent (30-79%)
HP:0011949	Acute infectious pneumonia	Frequent (30-79%)
HP:0001254	Lethargy	Occasional (5-29%)
HP:0001289	Confusion	Occasional (5-29%)
HP:0001882	Leukopenia	Occasional (5-29%)
HP:0002105	Hemoptysis	Occasional (5-29%)
HP:0002107	Pneumothorax	Occasional (5-29%)
HP:0002113	Pulmonary infiltrates	Occasional (5-29%)
HP:0002721	Immunodeficiency	Occasional (5-29%)
HP:0025144	Shivering	Occasional (5-29%)
HP:0025419	Pulmonary pneumatocele	Occasional (5-29%)
HP:0025439	Pharyngitis	Occasional (5-29%)
HP:0031273	Shock	Occasional (5-29%)
HP:0032016	Abnormal sputum	Occasional (5-29%)
HP:0100758	Gangrene	Occasional (5-29%)
HP:0100806	Sepsis	Occasional (5-29%)
HP:0000819	Diabetes mellitus	Very rare (<1-4%)
HP:0030955	Alcoholism	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	staphylococcal necrotizing pneumonia
Mondo ID	MONDO:0018183
Orphanet	36238
SNOMED CT	763888005
UMLS	C4706659
MedGen	1637863
GARD	0018821
Is cancer (heuristic)	no

Disease family

This is a subtype of respiratory system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › respiratory system disorder › staphylococcal necrotizing pneumonia

Related subtypes (58): lower respiratory tract disorder, respiratory system cancer, respiratory system benign neoplasm, allergic respiratory disease, paranasal sinus disorder, upper respiratory tract disorder, pertussis, severe acute respiratory syndrome, sleep apnea syndrome, diaphragm disorder, pulmonary tuberculosis, altitude sickness, perinatal asphyxia, pulmonary nodular lymphoid hyperplasia, tracheobronchopathia osteochondroplastica, Williams-Campbell syndrome, cystic fibrosis, growth delay-hydrocephaly-lung hypoplasia syndrome, laryngo-onycho-cutaneous syndrome, congenital pulmonary lymphangiectasia, familial primary pulmonary hypoplasia, Mounier-Kuhn syndrome, Young syndrome, lung agenesis-heart defect-thumb anomalies syndrome, sudden infant death-dysgenesis of the testes syndrome, alpha 1-antitrypsin deficiency, hereditary sclerosing poikiloderma with tendon and pulmonary involvement, autoimmune interstitial lung disease-arthritis syndrome, mucopolysaccharidosis-plus syndrome, congenital bronchobiliary fistula, bronchogenic cyst, primary ciliary dyskinesia, congenital pulmonary airway malformation, transient hyperammonemia of the newborn, congenital pulmonary sequestration, Siegler-Brewer-Carey syndrome, tracheal agenesis, 16q24.1 microdeletion syndrome, pulmonary veno-occlusive disease and/or pulmonary capillary haemangiomatosis, plastic bronchitis, recurrent respiratory papillomatosis, IgG4-related mediastinitis, bronchopulmonary dysplasia, infantile apnea, diffuse alveolar hemorrhage, respiratory or thoracic malformation, pulmonary agenesis, eosinophilic granuloma, disorder of pharynx, respiratory tract neoplasm, pulmonary alveolar proteinosis with hypogammaglobulinemia, respiratory tract infectious disorder, Middle East respiratory syndrome, reactive airway disease, acinar dysplasia, pulmonary hypoplasia, isolated left bronchial isomerism, bronchiectasis and nasal polyposis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.