Steroid-responsive encephalopathy associated with autoimmune thyroiditis
diseaseOn this page
Also known as Hashimoto's encephalitisHashimoto's encephalopathySREATsteroid-responsive encephalopathy associated with thyroid disease
Summary
Steroid-responsive encephalopathy associated with autoimmune thyroiditis (MONDO:0019385) is a disease. A subtype of postinfectious encephalitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: <1 / 1 000 000 (Europe)
- Phenotypes (HPO): 25
Clinical features
Epidemiology
Prevalence records
1 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Point prevalence | <1 / 1 000 000 | Europe | Not yet validated |
Signs & symptoms
Clinical features (HPO)
25 HPO clinical features (Orphanet curated; top 25 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0006846 | Acute encephalopathy | Obligate (100%) |
| HP:0005318 | Cerebral vasculitis | Very frequent (80-99%) |
| HP:0000872 | Hashimoto thyroiditis | Very frequent (80-99%) |
| HP:0000821 | Hypothyroidism | Frequent (30-79%) |
| HP:0000853 | Goiter | Frequent (30-79%) |
| HP:0001289 | Confusion | Frequent (30-79%) |
| HP:0002500 | Abnormal cerebral white matter morphology | Frequent (30-79%) |
| HP:0002902 | Hyponatremia | Frequent (30-79%) |
| HP:0003470 | Paralysis | Frequent (30-79%) |
| HP:0000709 | Psychosis | Occasional (5-29%) |
| HP:0000716 | Depression | Occasional (5-29%) |
| HP:0000739 | Anxiety | Occasional (5-29%) |
| HP:0001873 | Thrombocytopenia | Occasional (5-29%) |
| HP:0001945 | Fever | Occasional (5-29%) |
| HP:0001974 | Leukocytosis | Occasional (5-29%) |
| HP:0002017 | Nausea and vomiting | Occasional (5-29%) |
| HP:0002133 | Status epilepticus | Occasional (5-29%) |
| HP:0002197 | Generalized-onset seizure | Occasional (5-29%) |
| HP:0002315 | Headache | Occasional (5-29%) |
| HP:0002721 | Immunodeficiency | Occasional (5-29%) |
| HP:0007359 | Focal-onset seizure | Occasional (5-29%) |
| HP:0009102 | Anterior open-bite malocclusion | Occasional (5-29%) |
| HP:0012332 | Abnormal autonomic nervous system physiology | Occasional (5-29%) |
| HP:0002181 | Cerebral edema | Excluded (0%) |
| HP:0005991 | Limited neck flexion | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | steroid-responsive encephalopathy associated with autoimmune thyroiditis |
| Mondo ID | MONDO:0019385 |
| MeSH | C535841 |
| Orphanet | 83601 |
| UMLS | C0393639 |
| MedGen | 98280 |
| GARD | 0008570 |
| Is cancer (heuristic) | no |
Also known as: Hashimoto’s encephalitis · Hashimoto’s encephalopathy · SREAT · steroid-responsive encephalopathy associated with thyroid disease
Disease family
This is a subtype of postinfectious encephalitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › encephalomyelitis › encephalitis › infectious encephalitis › postinfectious encephalitis › steroid-responsive encephalopathy associated with autoimmune thyroiditis
Related subtypes (6): limbic encephalitis with LGI1 antibodies, Rasmussen subacute encephalitis, Bickerstaff brainstem encephalitis, acute disseminated encephalomyelitis, encephalitis lethargica, rubella encephalitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.