Streptococcal pneumonia

Summary

Streptococcal pneumonia (MONDO:0005972) is a disease and 19 clinical trials. A subtype of bacterial pneumonia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 19

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	streptococcal pneumonia
Mondo ID	MONDO:0005972
EFO	EFO:0007499
MeSH	D011018
DOID	DOID:0040084
ICD-10-CM	J13
SNOMED CT	233607000
UMLS	C0155862
MedGen	57615
Is cancer (heuristic)	no

Also known as: pneumococcal pneumonia · pneumonia due to streptococcus · streptococcal pneumonia · Streptococcus pneumoniae caused pneumonia · Streptococcus pneumoniae pneumonia

Disease family

This is a subtype of bacterial pneumonia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › bacterial pneumonia › streptococcal pneumonia

Related subtypes (7): anaerobic pneumonia, Legionnaires’ disease, Mycoplasma pneumoniae pneumonia, staphylococcal pneumonia, Klebsiella pneumonia, pneumonia caused by pseudomonas aeruginosa infection, pneumonia caused by gram negative bacteria

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Linezolid	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Aluminum Hydroxide.

Clinical trials & evidence

Clinical trials

Clinical trials: 19.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	8
PHASE4	5
PHASE1	4
PHASE2	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01028326	PHASE4	UNKNOWN	PCV10 Reactogenicity and Immunogenicity Study - Malindi
NCT01402245	PHASE4	COMPLETED	Targeting of Immune Response After Pneumococcal Vaccination
NCT02592486	PHASE4	COMPLETED	The Immunogenicity of Simultaneous Administration of Quadrivalent Influenza Vaccine and 23-valent Pneumococcal Vaccine
NCT03619252	PHASE4	COMPLETED	Pneumococcal Vaccination of Multiple Myeloma Patients on Novel Agents
NCT03838497	PHASE4	COMPLETED	Immunogenicity and Safety of 13-valent Pneumococcal Conjugate Vaccine Among HIV-infected Adults
NCT07035054	PHASE2	COMPLETED	Phase Ⅱ Clinical Trial of 24-valent Pneumococcal Polysaccharide Conjugate Vaccine
NCT01444001	PHASE1	COMPLETED	Study of an Investigational Pneumococcal Vaccine in Healthy Adult Volunteers
NCT01444339	PHASE1	COMPLETED	Study of Two Investigational Pneumococcal Vaccines in Healthy Adults
NCT01444352	PHASE1	COMPLETED	Study of an Investigational Pneumococcal Vaccine at Three Dose Levels in Healthy Adults
NCT03303976	PHASE1	COMPLETED	Phase I to Test a New Pneumococcal Vaccine
NCT07025876	EARLY_PHASE1	COMPLETED	PhaseⅠClinical Trial of 24-valent Pneumococcal Polysaccharide Conjugate Vaccine
NCT06699433	Not specified	RECRUITING	Artificial Intelligence-driven Virtual Standardized Pediatric Patients Trial
NCT02133469	Not specified	COMPLETED	PCV7 in the Prevention of Nasopharyngeal Carriage of Vaccine Serotype (VT) Streptococcus Pneumoniae
NCT02538211	Not specified	COMPLETED	The Role of the Intestinal Microbiome in Enteric and Systemic Vaccine Immune Responses
NCT03102840	Not specified	UNKNOWN	Understanding Pneumococcal Carriage and Disease 2017-2020
NCT03331952	Not specified	COMPLETED	A Study of Streptococcus Pneumonia Colonisation and Invasive Disease in Cambodian Children
NCT03851978	Not specified	COMPLETED	Pharmacist Impact on Pneumococcal Polysaccharide Vaccination Rates in Patients With Diabetes in a Supermarket Pharmacy Chain
NCT04944719	Not specified	UNKNOWN	Pneumococcal Nasopharyngeal Colonization as Predictor of Community-Acquired Pneumonia (CAP) in Adults With Chronic Diseases.
NCT07354425	Not specified	COMPLETED	Pneumococcal Community-Acquired Pneumonia Requiring Hospitalization Among Colombian Adults

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CHEMBL443232	0	1