Streptococcal sore throat

Summary

Streptococcal sore throat (MONDO:0021783) is a disease and 15 clinical trials. Top therapeutic interventions include amoxicillin and 17. A subtype of pharyngitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 15

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	streptococcal sore throat
Mondo ID	MONDO:0021783
ICD-10-CM	J02.0
NCIT	C116003
SNOMED CT	43878008
UMLS	C0036689
MedGen	508129
Is cancer (heuristic)	no

Also known as: Septic sore throat · Strep throat · strep throat · Strept throat · Streptococcal angina · Streptococcal pharyngitis · streptococcal pharyngitis

Disease family

This is a subtype of pharyngitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › respiratory system disorder › upper respiratory tract disorder › pharyngitis › streptococcal sore throat

Related subtypes (1): acute pharyngitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 15.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	13
PHASE1	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01310361	PHASE1	COMPLETED	Once-daily Therapy for Streptococcal Pharyngitis
NCT03361163	PHASE1	COMPLETED	Controlled Human Infection for Vaccination Against Streptococcus Pyogenes
NCT01558804	Not specified	RECRUITING	GRoup A StrePtococcus
NCT01441479	Not specified	COMPLETED	Strep A Fluorescent Immunoassay and Analyzer Field Study
NCT01491776	Not specified	UNKNOWN	Evaluation of the IND One Step Strep A Rapid Test vs. Culture
NCT01494792	Not specified	TERMINATED	Sofia Strep A FIA Field Study
NCT01561703	Not specified	COMPLETED	Comparing Healthcare Utilization Between Adenotonsillectomy Patients With and Without Postoperative Antibiotic Use
NCT01806103	Not specified	COMPLETED	Antimicrobial Stewardship for Primary Care Pediatricians
NCT02068469	Not specified	COMPLETED	In Vitro Diagnostic Device for the Detection of Strep A
NCT02534987	Not specified	COMPLETED	Integrated Clinical Prediction Rules: Bringing Evidence to Diverse Primary Care Settings
NCT03907449	Not specified	SUSPENDED	Preview Rapid Strep A Test Method Comparison Study
NCT04084977	Not specified	UNKNOWN	Dopaminergic Receptors in Sydenham’s Chorea
NCT04247243	Not specified	COMPLETED	Rapid POC GAS Diagnostics in the Paediatric ED
NCT04256694	Not specified	UNKNOWN	Rapid Strep Test Results
NCT05521568	Not specified	COMPLETED	Diagnostic Accuracy of Rapid Molecular Tests for Group A Streptococcal Pharyngitis Using Saliva Samples

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
AMOXICILLIN	4	1
17	0	1