Stromal keratitis

Summary

Stromal keratitis (MONDO:0015291) is a disease and 1 clinical trial. A subtype of herpes simplex virus keratitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: 1-9 / 100 000 (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 17
• Clinical trials: 1

Clinical features

Epidemiology

Prevalence records

2 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Point prevalence	1-9 / 100 000	4.2091	Worldwide	Validated
Annual incidence	1-9 / 100 000	5.4	France	Validated

Signs & symptoms

Clinical features (HPO)

17 HPO clinical features (Orphanet curated; top 17 by frequency):

HPO ID	Term	Frequency
HP:0007663	Reduced visual acuity	Very frequent (80-99%)
HP:0007765	Deep anterior chamber	Very frequent (80-99%)
HP:0012040	Corneal stromal edema	Very frequent (80-99%)
HP:0012108	Open angle glaucoma	Very frequent (80-99%)
HP:0000622	Blurred vision	Frequent (30-79%)
HP:0007812	Herpetiform corneal ulceration	Frequent (30-79%)
HP:0007906	Ocular hypertension	Frequent (30-79%)
HP:0009926	Epiphora	Frequent (30-79%)
HP:0012039	Descemet Membrane Folds	Frequent (30-79%)
HP:0012155	Decreased corneal sensation	Frequent (30-79%)
HP:0030953	Conjunctival hyperemia	Frequent (30-79%)
HP:0031448	Herpetiform vesicles	Frequent (30-79%)
HP:0100583	Corneal perforation	Frequent (30-79%)
HP:0000491	Keratitis	Occasional (5-29%)
HP:0000618	Blindness	Occasional (5-29%)
HP:0011134	Low-grade fever	Occasional (5-29%)
HP:0033834	Malaise	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	stromal keratitis
Mondo ID	MONDO:0015291
Orphanet	137599
ICD-11	1665288755
UMLS	C1318020
MedGen	727306
GARD	0019879
Is cancer (heuristic)	no

Disease family

This is a subtype of herpes simplex virus keratitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › viral infectious disease › primary viral infectious disease › Herpesviridae infectious disease › herpes simplex infectious disease › herpes simplex virus keratitis › stromal keratitis

Related subtypes (1): endotheliitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05156151	Not specified	UNKNOWN	Stromal Lenticule Implantation for Management of Herpetic Stromal Keratitis