Subacute inflammatory demyelinating polyneuropathy
disease diseaseOn this page
Also known as SIDPsubacute inflammatory demyelinating polyradiculoneuropathy
Summary
Subacute inflammatory demyelinating polyneuropathy (MONDO:0016102) is a disease. A subtype of demyelinating polyneuropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide)
- Phenotypes (HPO): 40
Clinical features
Signs & symptoms
Clinical features (HPO)
40 HPO clinical features (Orphanet curated; top 40 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0000762 | Decreased nerve conduction velocity | Very frequent (80-99%) |
| HP:0001324 | Muscle weakness | Very frequent (80-99%) |
| HP:0002922 | Increased CSF protein concentration | Very frequent (80-99%) |
| HP:0003431 | Decreased motor nerve conduction velocity | Very frequent (80-99%) |
| HP:0007377 | Abnormality of somatosensory evoked potentials | Very frequent (80-99%) |
| HP:0001284 | Areflexia | Frequent (30-79%) |
| HP:0001288 | Gait disturbance | Frequent (30-79%) |
| HP:0001974 | Leukocytosis | Frequent (30-79%) |
| HP:0002359 | Frequent falls | Frequent (30-79%) |
| HP:0003447 | Axonal loss | Frequent (30-79%) |
| HP:0003474 | Somatic sensory dysfunction | Frequent (30-79%) |
| HP:0003551 | Difficulty climbing stairs | Frequent (30-79%) |
| HP:0003565 | Elevated erythrocyte sedimentation rate | Frequent (30-79%) |
| HP:0004302 | Functional motor deficit | Frequent (30-79%) |
| HP:0006881 | Diffuse peripheral demyelination | Frequent (30-79%) |
| HP:0007078 | Decreased amplitude of sensory action potentials | Frequent (30-79%) |
| HP:0007141 | Sensorimotor neuropathy | Frequent (30-79%) |
| HP:0007220 | Demyelinating motor neuropathy | Frequent (30-79%) |
| HP:0007262 | Symmetric peripheral demyelination | Frequent (30-79%) |
| HP:0011096 | Peripheral demyelination | Frequent (30-79%) |
| HP:0012531 | Pain | Frequent (30-79%) |
| HP:0001266 | Choreoathetosis | Occasional (5-29%) |
| HP:0001337 | Tremor | Occasional (5-29%) |
| HP:0001430 | Abnormality of the calf musculature | Occasional (5-29%) |
| HP:0002403 | Positive Romberg sign | Occasional (5-29%) |
| HP:0002460 | Distal muscle weakness | Occasional (5-29%) |
| HP:0002936 | Distal sensory impairment | Occasional (5-29%) |
| HP:0003237 | Increased circulating IgG level | Occasional (5-29%) |
| HP:0003376 | Steppage gait | Occasional (5-29%) |
| HP:0003448 | Decreased sensory nerve conduction velocity | Occasional (5-29%) |
| HP:0006376 | Limited elbow flexion | Occasional (5-29%) |
| HP:0006844 | Absent patellar reflexes | Occasional (5-29%) |
| HP:0007230 | Decreased distal sensory nerve action potential | Occasional (5-29%) |
| HP:0008800 | Limited hip movement | Occasional (5-29%) |
| HP:0010505 | Limitation of movement at ankles | Occasional (5-29%) |
| HP:0012078 | Motor conduction block | Occasional (5-29%) |
| HP:0032169 | Severe infection | Occasional (5-29%) |
| HP:0002086 | Abnormality of the respiratory system | Very rare (<1-4%) |
| HP:0002270 | Abnormality of the autonomic nervous system | Very rare (<1-4%) |
| HP:0006824 | Cranial nerve paralysis | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | subacute inflammatory demyelinating polyneuropathy |
| Mondo ID | MONDO:0016102 |
| Orphanet | 206594 |
| ICD-11 | 1692167541 |
| SNOMED CT | 277189006 |
| UMLS | C0456517 |
| MedGen | 629329 |
| GARD | 0020355 |
| Is cancer (heuristic) | no |
Also known as: SIDP · subacute inflammatory demyelinating polyradiculoneuropathy
Disease family
This is a subtype of demyelinating polyneuropathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › peripheral nervous system disorder › peripheral neuropathy › polyneuropathy › demyelinating polyneuropathy › subacute inflammatory demyelinating polyneuropathy
Related subtypes (1): chronic inflammatory demyelinating polyradiculoneuropathy
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.