Subjective cognitive decline
diseaseOn this page
Summary
Subjective cognitive decline (MONDO:0850292) is a disease and 88 clinical trials. Top therapeutic interventions include mecamylamine, ginkgo, and inulin. A subtype of cognitive disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 88
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | subjective cognitive decline |
| Mondo ID | MONDO:0850292 |
| DOID | DOID:0080831 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of cognitive disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › cognitive disorder › subjective cognitive decline
Related subtypes (5): amnestic disorder, dementia, alexia, psychotic disorder, delirium
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 88.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 78 |
| PHASE2 | 6 |
| EARLY_PHASE1 | 2 |
| PHASE2/PHASE3 | 1 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02913664 | PHASE2/PHASE3 | COMPLETED | Risk Reduction for Alzheimer’s Disease |
| NCT05331144 | PHASE2 | RECRUITING | Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study) |
| NCT06588946 | PHASE2 | NOT_YET_RECRUITING | Β-OHB Supplementation and Brain Health in Older Adults |
| NCT07130669 | PHASE1/PHASE2 | RECRUITING | FACE Phase II (a Stage II Trial) |
| NCT07236190 | PHASE2 | RECRUITING | Biomarker-based Trial of NPC-1 for Alzheimer’s Pathology |
| NCT02755246 | PHASE2 | COMPLETED | Polyamine-enriched Diet in Healthy Older Adults With Subjective Cognitive Decline |
| NCT03057938 | PHASE2 | WITHDRAWN | Subjects With Subjective Cognitive Decline: 18F-Florbetaben Positron Emission Tomography Study |
| NCT03094546 | PHASE2 | COMPLETED | Polyamine-enriched Diet in Elderly Individuals With Subjective Cognitive Decline |
| NCT06002477 | EARLY_PHASE1 | RECRUITING | Attentional Mechanisms in SCD |
| NCT04756232 | EARLY_PHASE1 | COMPLETED | Cholinergic Mechanisms of Attention in Aging |
| NCT03271190 | Not specified | ACTIVE_NOT_RECRUITING | Impact of a Cognitive Intervention Enriched With Leisure Activities in Persons With Subjective Cognitive Decline |
| NCT03402919 | Not specified | RECRUITING | Comprehensive Assessment of Neurodegeneration and Dementia |
| NCT03772977 | Not specified | ACTIVE_NOT_RECRUITING | The Brain Health Champion Study |
| NCT03851523 | Not specified | RECRUITING | Longitudinal Study for the Characterization of the Phases of Subjective Perception of Cognitive Decline and Mild Cognitive Impairment of Alzheimer’s Disease. |
| NCT05014893 | Not specified | RECRUITING | Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline |
| NCT06078748 | Not specified | ACTIVE_NOT_RECRUITING | The Lifestyle Exercise and Diet Trial (LEAD) 2.0 |
| NCT06095063 | Not specified | RECRUITING | dTMS for Subjective Cognitive Decline |
| NCT06335836 | Not specified | RECRUITING | The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD) |
| NCT06358404 | Not specified | RECRUITING | Developing a Peer Support Intervention for Depression in SCD |
| NCT06403345 | Not specified | RECRUITING | A Feasiblity Study of Green Activity Program for People Living With Memory Challenges |
| NCT06429215 | Not specified | RECRUITING | REducing the Risk of COgnitive DEcline ad Dementia in Patients With Subjective Cognitive Decline Through an Immersive Virtual Reality and Telemedicine-based Multi-component Intervention: the SCD-ReCODED Study |
| NCT06433037 | Not specified | ACTIVE_NOT_RECRUITING | Gut-brain Health Effects of PREbiotics in Older Adults With Suspected COgnitive DEcline |
| NCT06539403 | Not specified | RECRUITING | Thinking About Memory: How Confident Are You in Your Memory, and Does it Change With Age? |
| NCT06542458 | Not specified | NOT_YET_RECRUITING | Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog |
| NCT06561906 | Not specified | RECRUITING | Establish Diagnostic and Prognostic Models for Preclinical AD Patients Based on Multimodal MRI, Behavioral, Genetic, and Plasma Biomarkers |
| NCT06621758 | Not specified | NOT_YET_RECRUITING | Communication Regarding Preclinical Dementia Diagnostic and Diagnostic Disclosure Among Patients with MCI and SCD |
| NCT06622889 | Not specified | ENROLLING_BY_INVITATION | The Effectiveness of Interventions Targeting Self-Perception of Aging in Older Adults with Subjective Cognitive Decline |
| NCT06632145 | Not specified | RECRUITING | Cog-Fun Ageing Participation-centered, Health Promotion for Older Adults |
| NCT06650969 | Not specified | RECRUITING | China Diabetes Cognitive Dysfunction Early Diagnosis and Intervention Study (China-DECODE Study) |
| NCT06669546 | Not specified | RECRUITING | Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment |
| NCT06701630 | Not specified | RECRUITING | Italian Adaptation and Validation of Functional and Behavioural Scales for Subjective Cognitive Decline, Mild Cognitive Impairment and Mild Dementia. |
| NCT06710652 | Not specified | NOT_YET_RECRUITING | Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment of Insomnia with Subjective Cognitive Decline |
| NCT06711952 | Not specified | RECRUITING | German Validation Study of the Subjective Cognitive Decline Questionnaire (SCD-Q) |
| NCT06758154 | Not specified | ACTIVE_NOT_RECRUITING | Efficacy and Olfactory Network of Electro-acupuncture for Subjective Cognitive Decline: A Multicenter Randomized Controlled Trial and fMRI Study |
| NCT06816797 | Not specified | RECRUITING | Testing the Cog-Fun Aging Program for Older Adults With Subjective Cognitive Decline |
| NCT06821828 | Not specified | NOT_YET_RECRUITING | The Efficacy of Modified Olfactory Training for MCI High-Risk Individuals |
| NCT06889818 | Not specified | RECRUITING | Korean Joint Registry for Alzheimer’s Treatment and Diagnostics (JOY-ALZ) |
| NCT06896825 | Not specified | RECRUITING | Increasing Physical Activity Through Social Support and Stress Resilience |
| NCT06993207 | Not specified | RECRUITING | HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population |
| NCT07019402 | Not specified | ACTIVE_NOT_RECRUITING | Internet-based Mind-Body Training for Brain Health |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| MECAMYLAMINE | 4 | 6 |
| GINKGO | 4 | 1 |
| INULIN | 4 | 1 |
| DEXTRIN | 3 | 1 |
| PHENCYCLIDINE HYDROCHLORIDE | -1 | 1 |
Related Atlas pages
- Drugs: Mecamylamine, Ginkgo, Inulin, Dextrin