Superficial corneal dystrophy

Summary

Superficial corneal dystrophy (MONDO:0020212) is a disease (an umbrella term covering 12 Mondo subtypes). A subtype of corneal dystrophy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Umbrella term: 12 Mondo subtypes

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Point prevalence	1-5 / 10 000	13.8	United States	Not yet validated

Identifiers

Disease identifiers

Field	Value
Canonical name	superficial corneal dystrophy
Mondo ID	MONDO:0020212
Orphanet	98625
SNOMED CT	430888006
UMLS	C2315777
MedGen	746687
Is cancer (heuristic)	no

Also known as: anterior corneal dystrophy · corneal epithelium corneal dystrophy (disease) · dystrophy of anterior cornea

Disease family

This is a subtype of corneal dystrophy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › corneal disorder › corneal dystrophy › superficial corneal dystrophy

Related subtypes (12): epithelial and subepithelial corneal dystrophy, epithelial-stromal TGFBI dystrophy, corneal endothelial dystrophy, Finnish type amyloidosis, autosomal dominant keratitis, macular dystrophy, fenestrated sheen type, band keratopathy, stromal corneal dystrophy, posterior corneal dystrophy, Chandler syndrome, Judge Misch wright syndrome, corneal dystrophy, punctiform and polychromatic pre-descemet

Subtypes (12): epithelial basement membrane dystrophy, Meesmann corneal dystrophy, epithelial recurrent erosion dystrophy, hereditary benign intraepithelial dyskeratosis, gelatinous drop-like corneal dystrophy, Lisch epithelial corneal dystrophy, Thiel-Behnke corneal dystrophy, Reis-Bucklers corneal dystrophy, subepithelial mucinous corneal dystrophy, corneal intraepithelial dyskeratosis-palmoplantar hyperkeratosis-laryngeal dyskeratosis syndrome, Grayson-Wilbrandt corneal dystrophy, honey-droplet corneal dystrophy

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.