Swine influenza

Summary

Swine influenza (MONDO:0005460) is a disease and 26 clinical trials. Top therapeutic interventions include influenza a virus, split virion. A subtype of influenza — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 26

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	swine influenza
Mondo ID	MONDO:0005460
EFO	EFO:0005226
DOID	DOID:0050211
NCIT	C80444
SNOMED CT	442696006
UMLS	C0276357
MedGen	1385137
Is cancer (heuristic)	no

Also known as: H1N1 flu · H1N1 Influenza · H1N1 Virus infection · Influenza A (H1N1) · Influenza A (H1N1) Virus infection · swine flu · Swine influenza virus caused influenza · Swine influenza virus influenza

Disease family

This is a subtype of influenza. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › viral infectious disease › viral respiratory tract infection › influenza › swine influenza

Related subtypes (1): avian influenza

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Influenza Virus Vaccine	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Rosuvastatin, Sodium Chloride.

Clinical trials & evidence

Clinical trials

Clinical trials: 26.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	13
PHASE2	9
PHASE4	2
PHASE3	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01002040	PHASE4	COMPLETED	Rapid Evaluation of Pandemic H1N1 Influenza Vaccine in Adults With HIV
NCT01127282	PHASE4	UNKNOWN	The Impact of Vitamin on the Clinical Course in Cases Infected by Novel H1N1 Influenza Virus A
NCT01040078	PHASE3	UNKNOWN	Novel Influenza A/H1N1 Split- Virion Vaccine in Healthy Children Aged 6 to 35 Month
NCT00952276	PHASE2	COMPLETED	A Study of Different Formulations of an Adjuvanted A/H1N1 Pandemic Vaccine in Healthy Adults and the Elderly
NCT00952419	PHASE2	COMPLETED	A Study of Different Formulations of an A/H1N1 Pandemic Vaccine in Healthy Children Aged 6 Months to 9 Years
NCT00953524	PHASE2	COMPLETED	A Study of Different Formulations of an A/H1N1 Pandemic Vaccine in Healthy Adults and the Elderly
NCT00954798	PHASE2	COMPLETED	A Study of Swine-origin A/H1N1 Influenza Vaccines in Healthy European Adults and the Elderly
NCT00956046	PHASE2	COMPLETED	A Study of Swine-origin A/H1N1 Influenza Vaccines in Healthy Europeans Children Aged 6 to 35 Months
NCT00956202	PHASE2	COMPLETED	A Study of Inactivated Swine-Origin A/H1N1 Influenza Vaccines in Healthy European Subjects Aged 3 to 17 Years
NCT01089660	PHASE2	COMPLETED	A Study of the Immunogenicity of Swine-origin A/H1N1 Influenza Vaccine in Healthy Adults
NCT01798602	PHASE2	TERMINATED	Collaborative H1N1 Adjuvant Treatment (CHAT) Pilot Trial
NCT02921997	PHASE2	COMPLETED	H7N9 Vaccination With and Without AS03 and Unadjuvanted H3N2v Vaccination: Standard and Systems Biology Analyses
NCT01177202	PHASE1	COMPLETED	Study of the Safety and Immunogenicity of H1N1 Vaccine
NCT00970606	Not specified	TERMINATED	STIP: Statin Trial for Influenza Patients
NCT00984451	Not specified	COMPLETED	A Pilot Study for Collection of Anti-Influenza A Immune Plasma
NCT00987012	Not specified	UNKNOWN	The Influence of Fortified Pomegranate Juice (Punica Granatum) on Seasonal Influenza and Swine Flu Patients
NCT01008683	Not specified	UNKNOWN	Antibody Production Following H1N1 Influenza Vaccination After Stem Cell and Heart Transplantation
NCT01011582	Not specified	COMPLETED	Characteristics and Outcomes of Intensive Care Unit Patients Admitted With Novel H1N1 Influenza or Seasonal Influenza
NCT01101074	Not specified	COMPLETED	Observational Safety and Effectiveness Study of Adjuvanted Swine Origin A (H1N1) Pandemic Subunit Egg Derived Vaccine
NCT01298206	Not specified	COMPLETED	Case-control Study of Pandemic A/H1N1 Influenza Risk Factors In Lebanon
NCT01421251	Not specified	UNKNOWN	H1N1 Vaccine Safety in Manitoba, Canada
NCT03641690	Not specified	COMPLETED	Serum and Bronchoalveolar Inflammatory Parameters in Patients With Severe Adult Respiratory Distress Syndrome
NCT04497311	Not specified	UNKNOWN	Tomographic Findings in COVID-19 and Influenza
NCT04810949	Not specified	TERMINATED	Vitamine D3 Supplementation in Patients With Serum Values +/- 20ng/ml
NCT04933994	Not specified	COMPLETED	Comparison of COVID-19 and H1N1 Influenza Pneumonia
NCT05080933	Not specified	COMPLETED	ECMO for COVID-19 vs Influenza A H1N1 Associated ARDS

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
INFLUENZA A VIRUS, SPLIT VIRION	4	1
CHEMBL1357356	0	1