Sympathetic ophthalmia
disease diseaseOn this page
Also known as sympathetic uveitis
Summary
Sympathetic ophthalmia (MONDO:0019198) is a disease. A subtype of panuveitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: <1 / 1 000 000 (United Kingdom) [Orphanet-validated]
- Phenotypes (HPO): 26
Clinical features
Epidemiology
Prevalence records
2 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Annual incidence | <1 / 1 000 000 | 0.03 | United Kingdom | Validated |
| Point prevalence | 1-9 / 1 000 000 | 0.6 | Europe | Not yet validated |
Signs & symptoms
Clinical features (HPO)
26 HPO clinical features (Orphanet curated; top 26 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0007663 | Reduced visual acuity | Very frequent (80-99%) |
| HP:0000501 | Glaucoma | Frequent (30-79%) |
| HP:0000518 | Cataract | Frequent (30-79%) |
| HP:0000541 | Retinal detachment | Frequent (30-79%) |
| HP:0011531 | Vitritis | Frequent (30-79%) |
| HP:0025341 | Corneal keratic precipitates | Frequent (30-79%) |
| HP:0025560 | Anterior chamber cells | Frequent (30-79%) |
| HP:0030823 | Scleral thickening | Frequent (30-79%) |
| HP:0000360 | Tinnitus | Occasional (5-29%) |
| HP:0000365 | Hearing impairment | Occasional (5-29%) |
| HP:0000573 | Retinal hemorrhage | Occasional (5-29%) |
| HP:0000613 | Photophobia | Occasional (5-29%) |
| HP:0001045 | Vitiligo | Occasional (5-29%) |
| HP:0001085 | Papilledema | Occasional (5-29%) |
| HP:0001596 | Alopecia | Occasional (5-29%) |
| HP:0002290 | Poliosis | Occasional (5-29%) |
| HP:0002315 | Headache | Occasional (5-29%) |
| HP:0007680 | Depigmented fundus | Occasional (5-29%) |
| HP:0007906 | Ocular hypertension | Occasional (5-29%) |
| HP:0010783 | Erythema | Occasional (5-29%) |
| HP:0011484 | Posterior synechiae of the anterior chamber | Occasional (5-29%) |
| HP:0012123 | Posterior uveitis | Occasional (5-29%) |
| HP:0040049 | Macular edema | Occasional (5-29%) |
| HP:0100832 | Vitreous floaters | Occasional (5-29%) |
| HP:0200026 | Ocular pain | Occasional (5-29%) |
| HP:6000710 | Dalen Fuchs nodules | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | sympathetic ophthalmia |
| Mondo ID | MONDO:0019198 |
| EFO | EFO:1001205 |
| MeSH | D009879 |
| Orphanet | 79098 |
| DOID | DOID:12029 |
| ICD-10-CM | H44.13 |
| ICD-11 | 1639718137 |
| SNOMED CT | 75315001 |
| UMLS | C0029077 |
| MedGen | 45203 |
| GARD | 0018939 |
| MedDRA | 10042742 |
| Is cancer (heuristic) | no |
Also known as: sympathetic ophthalmia · sympathetic uveitis
Disease family
This is a subtype of panuveitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › uveal disorder › uveitis › panuveitis › sympathetic ophthalmia
Related subtypes (3): infectious panuveitis, idiopathic panuveitis, Vogt-Koyanagi-Harada disease
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated or in trials for this disease
4 approved drugs — disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Status |
|---|---|
| Cortisone Acetate | Approved (phase 4) |
| Dexamethasone | Approved (phase 4) |
| Prednisolone | Approved (phase 4) |
| Prednisone | Approved (phase 4) |
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.