T2-high asthma

Summary

T2-high asthma (MONDO:0956975) is a disease with 18 GWAS associations across 1 studies. A subtype of chronic asthma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• GWAS associations: 18

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	T2-high asthma
Mondo ID	MONDO:0956975
DOID	DOID:0080817
Is cancer (heuristic)	no

Data availability: 18 GWAS associations (1 study).

Disease family

This is a subtype of chronic asthma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › respiratory system disorder › lower respiratory tract disorder › bronchial disorder › asthma › chronic asthma › T2-high asthma

Related subtypes (4): extrinsic asthma, intermittent asthma, T2-low asthma, nocturnal asthma

Genetics & variants

GWAS landscape

18 GWAS associations across 1 studies. Top hits map to 14 distinct genes (as reported by GWAS).

Top associations by p-value

rsID	p-value	Gene	Risk allele	Odds ratio
rs2381416	2e-22	RANBP6 - GTF3AP1	?	1.24
rs653178	1e-19	ATXN2	?	1.2
rs17622208	5e-19	SLC22A5	?	0.84
rs1444782	2e-18	LINC02676 - LINC00709	?	0.84
rs4328821	2e-18	LINC01565 - RPN1	?	0.75
rs10206753	5e-16	IL1RL1, IL18R1	?	0.84
rs34250758	2e-14	HLA-DQA1	?	1.2
rs2244012	2e-12	RAD50	?	1.19
rs34210653	1e-11	ALOX15	?	0.58
rs2856816	7e-11	HLA-DPB1, HLA-DPA1	?	0.8
rs12507197	1e-09	KLF3-AS1	?	1.16
rs1847472	2e-09	BACH2	?	0.88
rs10995251	2e-09	LINC02929	?	0.88
rs6909253	2e-09	RNF39 - TRIM31-AS1	?	1.13
rs6720394	8e-09	MIR4435-2HG	?	1.19
rs6711452	2e-08	NCAPH - NEURL3	?	1.13
rs1106639	3e-08	D2HGDH	?	0.88
rs17142880	4e-08	ITGB8 - EEF1A1P27	?	0.88

Top studies (by case count)

Study	Lead author	Year	Cases	Controls	Title
GCST90693197	Li H	2023	0	0	Genetic relationships between high blood eosinophil count, asthma susceptibility and asthma severity.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

Tier	Variants
Tier 1: coding	3
Tier 2: splice/UTR	0
Tier 3: regulatory	0
Tier 4: intronic/intergenic	15

MAF distribution

Bucket	Variants
common (>=0.05)	18
low_freq (0.01-0.05)	0
rare (<0.01)	0
unknown	0

Functional consequences

Consequence	Count
intron_variant	12
intergenic_variant	3
missense_variant	3

Top variants

rsID	Chr	Pos	Alleles	MAF	Consequence	Gene	p-value	Tier
rs2381416	9	6193455	C>A,G,T	0.05	intergenic_variant	RANBP6 - GTF3AP1	2e-22	Tier 4: intronic/intergenic
rs653178	12	111569952	C>A,G,T	0.05	intron_variant	ATXN2	1e-19	Tier 4: intronic/intergenic
rs17622208	5	132381358	G>A,T	0.05	intron_variant	SLC22A5	5e-19	Tier 4: intronic/intergenic
rs1444782	10	9016708	G>A	0.05	intron_variant	LINC02676 - LINC00709	2e-18	Tier 4: intronic/intergenic
rs4328821	3	128597592	A>C,G	0.05	intron_variant	LINC01565 - RPN1	2e-18	Tier 4: intronic/intergenic
rs10206753	2	102351902	T>C,G	0.05	missense_variant	IL1RL1, IL18R1	5e-16	Tier 1: coding
rs34250758	6	32639599	G>A,C,T	0.05	intron_variant	HLA-DQA1	2e-14	Tier 4: intronic/intergenic
rs2244012	5	132565533	A>C,G,T	0.05	intron_variant	RAD50	2e-12	Tier 4: intronic/intergenic
rs34210653	17	4632019	G>A	0.05	missense_variant	ALOX15	1e-11	Tier 1: coding
rs2856816	6	33077723	T>C	0.05	intron_variant	HLA-DPB1, HLA-DPA1	7e-11	Tier 4: intronic/intergenic
rs12507197	4	38662039	T>C	0.05	intron_variant	KLF3-AS1	1e-09	Tier 4: intronic/intergenic
rs1847472	6	90263440	C>A,G,T	0.05	intron_variant	BACH2	2e-09	Tier 4: intronic/intergenic
rs10995251	10	62638706	C>T	0.05	intron_variant	LINC02929	2e-09	Tier 4: intronic/intergenic
rs6909253	6	30087866	G>A,C,T	0.05	intergenic_variant	RNF39 - TRIM31-AS1	2e-09	Tier 4: intronic/intergenic
rs6720394	2	111231795	T>G	0.05	intron_variant	MIR4435-2HG	8e-09	Tier 4: intronic/intergenic
rs6711452	2	96473570	G>A	0.05	intron_variant	NCAPH - NEURL3	2e-08	Tier 4: intronic/intergenic
rs1106639	2	241751260	G>A	0.05	missense_variant	D2HGDH	3e-08	Tier 1: coding
rs17142880	7	20467291	G>A,T	0.05	intergenic_variant	ITGB8 - EEF1A1P27	4e-08	Tier 4: intronic/intergenic

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.