Testicular non-seminomatous germ cell cancer

Summary

Testicular non-seminomatous germ cell cancer (MONDO:0003403) is a cancer and 1 clinical trial. Top therapeutic interventions include cisplatin and sodium thiosulfate. A subtype of malignant testicular germ cell tumor — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 1

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	testicular non-seminomatous germ cell cancer
Mondo ID	MONDO:0003403
DOID	DOID:5345
NCIT	C5027
UMLS	C1334625
MedGen	233162
GARD	0023503
Is cancer (heuristic)	yes

Also known as: malignant non-seminomatous germ cell cancer of testis · malignant non-seminomatous germ cell cancer of the testis · malignant non-seminomatous germ cell neoplasm of testis · malignant non-seminomatous germ cell neoplasm of the testis · malignant non-seminomatous germ cell tumor of testis · malignant non-seminomatous germ cell tumor of the testis · malignant non-seminomatous germ cell tumour of testis · malignant non-seminomatous germ cell tumour of the testis · malignant testicular non-seminomatous germ cell neoplasm · malignant testicular non-seminomatous germ cell tumor · malignant testicular non-seminomatous germ cell tumour · testicular germ cell tumor non-seminomatous, malignant · testicular germ cell tumour non-seminomatous, malignant · testicular non-seminomatous germ cell cancer · testicular non-seminomatous germ cell tumor, malignant · testicular non-seminomatous malignant germ cell neoplasm

Disease family

This is a subtype of malignant testicular germ cell tumor. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › reproductive system cancer › male reproductive organ cancer › testicular cancer › malignant testicular germ cell tumor › testicular non-seminomatous germ cell cancer

Related subtypes (5): mixed testicular germ cell cancer, testicular seminoma, testis refractory cancer, testis polyembryoma, malignant teratoma of testis

Subtypes (3): testicular yolk sac tumor, choriocarcinoma of testis, testicular embryonal carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07218913	PHASE1	RECRUITING	Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CISPLATIN	4	1
SODIUM THIOSULFATE	4	1