Testicular non-seminomatous germ cell tumor

Summary

Testicular non-seminomatous germ cell tumor (MONDO:0006447) is a cancer and 2 clinical trials. Top therapeutic interventions include ipilimumab. A subtype of testicular germ cell tumor — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Prevalence: 1-9 / 100 000 (Europe) [Orphanet-validated]
• Clinical trials: 2

Clinical features

Epidemiology

Prevalence records

2 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Annual incidence	1-9 / 100 000	1.21	Europe	Validated
Lifetime Prevalence	1-5 / 10 000	33.53	Europe	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	testicular non-seminomatous germ cell tumor
Mondo ID	MONDO:0006447
EFO	EFO:1000570
Orphanet	363494
DOID	DOID:4086
NCIT	C9313
UMLS	C2057625
MedGen	890627
GARD	0017561
Is cancer (heuristic)	yes

Also known as: non-dysgerminomatous germ cell tumor of testis · non-dysgerminomatous germ cell tumour of testis · non-seminomatous germ cell tumor of testis · non-seminomatous germ cell tumour of testis · testicular germ cell tumor non-seminomatous · testicular germ cell tumour non-seminomatous · testicular non seminomatous germ cell tumor · testicular non seminomatous germ cell tumour · testicular non-dysgerminomatous germ cell tumor · testicular non-dysgerminomatous germ cell tumour · testicular non-seminomatous germ cell tumor

Disease family

This is a subtype of testicular germ cell tumor. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › germ cell tumor › gonadal germ cell tumor › testicular germ cell tumor › testicular non-seminomatous germ cell tumor

Related subtypes (5): testicular pure germ cell tumor, malignant testicular germ cell tumor, childhood testicular germ cell tumor, testicular germ cell tumor 1, testicular teratoma

Subtypes (2): testicular trophoblastic tumor, testicular non-seminomatous germ cell cancer

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE3	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01726374	PHASE3	COMPLETED	Trial of 1 Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Testis Tumours
NCT02834013	PHASE2	ACTIVE_NOT_RECRUITING	Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
IPILIMUMAB	4	1