Thoracic cancer
diseaseOn this page
Also known as cancer of thoracic segment of trunkmalignant neoplasm of the thoraxmalignant neoplasm of thoracic segment of trunkmalignant neoplasm of thoraxmalignant thoracic neoplasmmalignant thoracic segment of trunk neoplasmmalignant thoracic tumormalignant thoracic tumourmalignant tumor of the thoraxmalignant tumor of thoraxmalignant tumour of the thoraxmalignant tumour of thoraxthoracic segment of trunk cancerthoracic tumorthoracic tumourthorax neoplasmtumor of thoraxtumour of thorax
Summary
Thoracic cancer (MONDO:0003274) is a cancer (an umbrella term covering 8 Mondo subtypes) and 89 clinical trials. Top therapeutic interventions include cabozantinib, gemcitabine, and sotorasib. A subtype of cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 8 Mondo subtypes
- Clinical trials: 89
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | thoracic cancer |
| Mondo ID | MONDO:0003274 |
| DOID | DOID:5093 |
| ICD-10-CM | C76.1 |
| NCIT | C3576 |
| SNOMED CT | 188361007 |
| UMLS | C0153661 |
| MedGen | 56320 |
| Anatomy (UBERON) | UBERON:0000915 |
| Is cancer (heuristic) | yes |
Also known as: cancer of thoracic segment of trunk · malignant neoplasm of the thorax · malignant neoplasm of thoracic segment of trunk · malignant neoplasm of thorax · malignant thoracic neoplasm · malignant thoracic segment of trunk neoplasm · malignant thoracic tumor · malignant thoracic tumour · malignant tumor of the thorax · malignant tumor of thorax · malignant tumour of the thorax · malignant tumour of thorax · thoracic segment of trunk cancer · thoracic tumor · thoracic tumour · thorax neoplasm · tumor of thorax · tumour of thorax
Disease family
This is a subtype of cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › thoracic cancer
Related subtypes (32): respiratory system cancer, immune system cancer, musculoskeletal system cancer, integumentary system cancer, peritoneum cancer, cardiovascular cancer, reproductive system cancer, malignant giant cell tumor, digestive system cancer, lipomatous cancer, malignant glomus tumor, malignant mesenchymoma, carcinoma, sarcoma, blastoma, head and neck cancer, malignant mixed neoplasm, nervous system cancer, retroperitoneal cancer, malignant germ cell tumor, malignant mesothelioma, malignant urinary system neoplasm, childhood malignant neoplasm, anaplastic cancer, malignant spindle cell neoplasm, high grade malignant neoplasm, malignant endocrine neoplasm, malignant soft tissue neoplasm, secondary malignant neoplasm, refractory malignant neoplasm, malignant adenoma, cancer of unknown primary site
Subtypes (8): heart cancer, sternum cancer, mediastinal cancer, Askin tumor, pleural cancer, breast cancer, lung cancer, malignant neoplasm of chest wall
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 89.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 76 |
| PHASE1 | 7 |
| PHASE1/PHASE2 | 3 |
| EARLY_PHASE1 | 2 |
| PHASE4 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05521789 | PHASE4 | RECRUITING | Erector Spinae Block for Thoracic Surgery |
| NCT06922591 | PHASE1/PHASE2 | RECRUITING | Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients |
| NCT07407582 | PHASE1/PHASE2 | RECRUITING | Ph. I/II Sodium Thiosulfate for OtoProtection During Cisplatin (STOP-CIS) |
| NCT04841538 | PHASE1/PHASE2 | WITHDRAWN | A Study of ES101 (PD-L1x4-1BB Bispecific Antibody) in Patients With Advanced Malignant Thoracic Tumors |
| NCT05092373 | PHASE1 | RECRUITING | Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax |
| NCT06333951 | PHASE1 | ACTIVE_NOT_RECRUITING | Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104). |
| NCT06558175 | PHASE1 | NOT_YET_RECRUITING | Reirradiation Dose Escalation in Thoracic Cancers |
| NCT01552434 | PHASE1 | TERMINATED | Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease |
| NCT01639911 | PHASE1 | COMPLETED | Phase I Study of MLN8237 and Pazopanib in Patients With Solid Tumors |
| NCT02045368 | PHASE1 | COMPLETED | Study of Insulin-like Growth Factor (IGF)-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R |
| NCT02587455 | PHASE1 | COMPLETED | Pembrolizumab and Palliative Radiotherapy in Lung |
| NCT07389525 | EARLY_PHASE1 | NOT_YET_RECRUITING | Immune Checkpoint Inhibitor (ICI)-Drug-Drug Interaction (DDI) Study |
| NCT04044872 | EARLY_PHASE1 | TERMINATED | Hyperpolarized Carbon 13-Based Metabolic Imaging to Detect Radiation-Induced Cardiotoxicity |
| NCT00242723 | Not specified | RECRUITING | Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining |
| NCT02941458 | Not specified | RECRUITING | Thoracic Tumours Register |
| NCT03794635 | Not specified | ACTIVE_NOT_RECRUITING | An Intervention to Help Patients and Caregivers Manage Stress and Improve Communication Skills When Talking About Cancer |
| NCT05038254 | Not specified | ACTIVE_NOT_RECRUITING | Enhanced Outpatient Symptom Management to Reduce Acute Care Visits Due to Chemotherapy-Related Adverse Events |
| NCT05053230 | Not specified | RECRUITING | A Study Evaluating the Integrative Medicine at Home (IM@HOME) Program in People With Cancer |
| NCT05189054 | Not specified | RECRUITING | Safety and Efficacy of SBRT in the Reirradiation for Ultra-central Thoracic Malignant Tumors |
| NCT05313191 | Not specified | RECRUITING | Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors |
| NCT05349552 | Not specified | RECRUITING | Safety and Efficacy of SBRT in the Treatment of Thoracic Malignant Tumors at Different Sites |
| NCT05375643 | Not specified | RECRUITING | SURGE: Supporting UnderRepresented Minorities in Genomics-based Cancer Trial Enrollment (Intervention) |
| NCT05406167 | Not specified | RECRUITING | Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System |
| NCT05629065 | Not specified | ACTIVE_NOT_RECRUITING | Pathways to Advance Targeted and Helpful Serious Illness Conversations (PATH-SIC) |
| NCT05975619 | Not specified | ACTIVE_NOT_RECRUITING | A Prospective Imaging Study of the Integrated TrueBeam-HyperSight CBCT System |
| NCT06185062 | Not specified | RECRUITING | Pelvic Cancer Registry for Online Adapted Radiotherapy |
| NCT06342284 | Not specified | RECRUITING | Patient-Generated Health Data Collection During Chemoradiotherapy for Lung Cancer |
| NCT06396598 | Not specified | RECRUITING | Electronic Symptom Monitoring Program for Triggered Palliative Referrals in Patients With Thoracic Cancer |
| NCT06581107 | Not specified | NOT_YET_RECRUITING | Validate the Safety and Feasibility of the CT-guided Interventional Robot in Percutaneous Lung Cryablation Procedures |
| NCT06633224 | Not specified | RECRUITING | Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT |
| NCT06634706 | Not specified | NOT_YET_RECRUITING | SCINTIX [BgRT} Using RMRS in Solid and Soft Tissue Tumors |
| NCT06669104 | Not specified | RECRUITING | Thoracic Surgery by the Medtronic Hugo™ Robotic System |
| NCT06681233 | Not specified | RECRUITING | Feasibility Study of CBCT for IGRT in Cancer Patients |
| NCT06840288 | Not specified | RECRUITING | Bronchoscopic Lung Ablation of Small Thoracic Tumors: the Blastt Registry |
| NCT06950073 | Not specified | RECRUITING | Curatively Intended Thoracic Reirradiation |
| NCT06996249 | Not specified | RECRUITING | Prospective Data Collection Initiative on Thoracic Malignancies |
| NCT07016022 | Not specified | RECRUITING | Variability and Post-op AEs: Does Preoperative CardioPulmonary Variability Assessment Identify Risk of Postoperative Adverse Events Following Thoracic Surgery |
| NCT07154355 | Not specified | RECRUITING | Community Exercise Treating Effect on Cardiopulmonary Disease Patients |
| NCT07455513 | Not specified | NOT_YET_RECRUITING | A Novel Tobacco Cessation Resource for Smokers With a Diagnosed or Suspected Thoracic Cancer |
| NCT07606287 | Not specified | NOT_YET_RECRUITING | Studying the Workflow of the American College of Surgeons Geriatric Surgery Program to Improve Clinical Outcomes in Older Adults Undergoing Surgery at the James Cancer Hospital |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CABOZANTINIB | 4 | 1 |
| GEMCITABINE | 4 | 1 |
| SOTORASIB | 4 | 1 |
| ALISERTIB | 3 | 1 |
| CHEMBL5174767 | 0 | 1 |
| CHEMBL6175025 | 0 | 1 |
| CHEMBL454299 | 0 | 1 |
Related Atlas pages
- Drugs: Cabozantinib, Gemcitabine, Sotorasib, Alisertib