Thymic epithelial neoplasm
diseaseOn this page
Also known as epithelial neoplasm of the Thymusepithelial neoplasm of Thymusepithelial tumor of the Thymusepithelial tumor of Thymusepithelial tumour of the Thymusepithelial tumour of ThymusTENTetthymic epithelial tumorthymic epithelial tumourthymic epithelium neoplasmthymoma, adultThymus epithelial neoplasmThymus epithelial tumorThymus epithelial tumour
Summary
Thymic epithelial neoplasm (MONDO:0018079) is a cancer and 26 clinical trials. Top therapeutic interventions include pembrolizumab, selinexor, and bintrafusp alfa. A subtype of thymus neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Prevalence: 1-9 / 1 000 000 (Europe) [Orphanet-validated]
- Clinical trials: 26
Clinical features
Epidemiology
Prevalence records
2 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.17 | Europe | Validated |
| Annual incidence | 1-9 / 100 000 | 1.3 | United States | Validated |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | thymic epithelial neoplasm |
| Mondo ID | MONDO:0018079 |
| MeSH | C536905 |
| Orphanet | 3398 |
| NCIT | C6450 |
| UMLS | C1266101 |
| MedGen | 220416 |
| GARD | 0005201 |
| Anatomy (UBERON) | UBERON:0002370 |
| Is cancer (heuristic) | yes |
Also known as: epithelial neoplasm of the Thymus · epithelial neoplasm of Thymus · epithelial tumor of the Thymus · epithelial tumor of Thymus · epithelial tumour of the Thymus · epithelial tumour of Thymus · TEN · Tet · thymic epithelial tumor · thymic epithelial tumour · thymic epithelium neoplasm · thymoma, adult · Thymus epithelial neoplasm · thymus epithelial neoplasm · Thymus epithelial tumor · Thymus epithelial tumour
Disease family
This is a subtype of thymus neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › endocrine gland neoplasm › thymus neoplasm › thymic epithelial neoplasm
Related subtypes (3): thymus cancer, thymic neuroendocrine tumor, benign neoplasm of thymus
Subtypes (2): thymic carcinoma, thymoma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 26.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE2 | 13 |
| Not specified | 12 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06425224 | PHASE3 | RECRUITING | Effectiveness and Safety of TENS Therapy for Premature Ejaculation |
| NCT04417660 | PHASE2 | ACTIVE_NOT_RECRUITING | Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic Carcinoma |
| NCT05104736 | PHASE2 | RECRUITING | PT-112 in Subjects With Thymoma and Thymic Carcinoma |
| NCT06200233 | PHASE2 | NOT_YET_RECRUITING | Rivoceranib in Patients With Metastatic Thymic Epithelial Tumor |
| NCT06311955 | PHASE2 | RECRUITING | Clinical Study of Postoperative Carbon Ion Radiotherapy for Thymus Tumor With Residual Tumor |
| NCT06311968 | PHASE2 | RECRUITING | The Clinical Study of Post-operative Proton Radiotherapy for Thymus Tumor |
| NCT06654830 | PHASE2 | NOT_YET_RECRUITING | RATT Vs. VATT for Early-stage TETs |
| NCT07343453 | PHASE2 | NOT_YET_RECRUITING | A Single-Arm, Phase II Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan in Second-Line and Subsequent Treatments for Advanced Thymic Epithelial Tumors |
| NCT02607631 | PHASE2 | COMPLETED | A Study of Pembrolizumab for Patients With Thymic Epithelial Tumor |
| NCT03193437 | PHASE2 | TERMINATED | Selinexor in Patients With Advanced Thymic Epithelial Tumor Progressing After Primary Chemotherapy |
| NCT03466827 | PHASE2 | UNKNOWN | Selinexor in Patients With Advanced Thymoma and Thymic Carcinoma |
| NCT03858582 | PHASE2 | UNKNOWN | neoadjuvant_thymic Epithelial Tumor |
| NCT04517539 | PHASE2 | UNKNOWN | Abscopal Effect of SBRT in Combination With rhGM-CSF and INF-α 2b for Metastatic Thymic Epithelial Tumors |
| NCT04667793 | PHASE2 | UNKNOWN | Clinical Study of Neoadjuvant PD-1 Antibody (Toripalimab) Plus Chemotherapy for Locally Advanced Thymic Epithelial Tumor |
| NCT02146170 | Not specified | RECRUITING | Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors |
| NCT04522687 | Not specified | RECRUITING | Influence of Radiotherapy and Chemotherapy in the Value of Peripheral Blood Lymphocyte Subsets Among Thoracic Cancer |
| NCT05667948 | Not specified | RECRUITING | Molecular Analysis and Treatment Options of Thymic Malignancies |
| NCT06301945 | Not specified | RECRUITING | Artificial Intelligence Prediction Tool in Thymic Epithelial Tumors |
| NCT06421805 | Not specified | RECRUITING | Establishing Prospective Mediastinal Tumor Database of PUMCH |
| NCT06692062 | Not specified | RECRUITING | Hypofractionated Radiotherapy for Thymic Epithelial Tumors |
| NCT07328074 | Not specified | NOT_YET_RECRUITING | Electrocautery Resection Combined With HITHOC for Thymic Epithelial Tumors With Pleural Metastasis |
| NCT07383142 | Not specified | NOT_YET_RECRUITING | Intrathoracic Chemotherapy for TETs With Pleural Spread or Recurrence (CHOICE-2) |
| NCT02724696 | Not specified | UNKNOWN | French National Observatory of Patients With Thymic Epithelial Tumor |
| NCT03212027 | Not specified | UNKNOWN | Preoperative Prediction of of Thymic Epithelial Tumors by Diffusion-Weighted MR Imaging |
| NCT03548870 | Not specified | TERMINATED | Transcutaneous Electrical Nerve Stimulation During Exercise in Patients With COPD |
| NCT05446935 | Not specified | UNKNOWN | Intrathoracic Chemotherapy for TETs With Pleural Spread or Recurrence |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PEMBROLIZUMAB | 4 | 2 |
| SELINEXOR | 4 | 1 |
| BINTRAFUSP ALFA | 3 | 1 |
| DAPOXETINE | 3 | 1 |
| SACITUZUMAB TIRUMOTECAN | 3 | 1 |
| IMIFOPLATIN | 1 | 1 |