Tooth ankylosis
diseaseOn this page
Also known as abnormal fusion of dental cementum with alveolar boneankylosis (disease) of calcareous toothankylosis of teethankylosis of toothcalcareous tooth ankylosis (disease)molar I reinclusionsecondary retention of permanent molars
Summary
Tooth ankylosis (MONDO:0008007) is a disease and 1 clinical trial. A subtype of tooth hard tissue disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide)
- Phenotypes (HPO): 4
- Clinical trials: 1
Clinical features
Signs & symptoms
Clinical features (HPO)
4 HPO clinical features (Orphanet curated; top 4 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0009804 | Tooth agenesis | Very frequent (80-99%) |
| HP:0000682 | Abnormality of dental enamel | Frequent (30-79%) |
| HP:0000303 | Mandibular prognathia | Occasional (5-29%) |
| HP:0004209 | Clinodactyly of the 5th finger | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | tooth ankylosis |
| Mondo ID | MONDO:0008007 |
| MeSH | D020254 |
| OMIM | 157950 |
| Orphanet | 1077 |
| DOID | DOID:12661 |
| ICD-10-CM | K03.5 |
| ICD-11 | 2066427602 |
| SNOMED CT | 14901003 |
| UMLS | C0155930 |
| MedGen | 57843 |
| GARD | 0000701 |
| MedDRA | 10044019 |
| Anatomy (UBERON) | UBERON:0001091 |
| Is cancer (heuristic) | no |
Also known as: abnormal fusion of dental cementum with alveolar bone · ankylosis (disease) of calcareous tooth · ankylosis of teeth · ankylosis of tooth · calcareous tooth ankylosis (disease) · molar I reinclusion · secondary retention of permanent molars
Disease family
This is a subtype of tooth hard tissue disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › tooth disorder › tooth hard tissue disease › tooth ankylosis
Related subtypes (6): tooth resorption, dental enamel hypoplasia, dentin sensitivity, dental caries, hypercementosis, dentin dysplasia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 1.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07185711 | Not specified | COMPLETED | RFA and Bite Force in COD Teeth |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.