Trachea squamous cell carcinoma

Summary

Trachea squamous cell carcinoma (MONDO:0001419) is a cancer and 1 clinical trial. Top therapeutic interventions include toripalimab. A subtype of trachea carcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 1

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	trachea squamous cell carcinoma
Mondo ID	MONDO:0001419
EFO	EFO:1000600
DOID	DOID:12003
ICD-11	1439188070
NCIT	C4448
SNOMED CT	254620000
UMLS	C0345946
MedGen	91059
Anatomy (UBERON)	UBERON:0003126
Is cancer (heuristic)	yes

Also known as: epidermoid carcinoma of the trachea · epidermoid carcinoma of trachea · squamous cell carcinoma of the trachea · squamous cell carcinoma of trachea · trachea epidermoid carcinoma · trachea squamous cell carcinoma · tracheal epidermoid carcinoma · tracheal squamous cell carcinoma

Disease family

This is a subtype of trachea carcinoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › respiratory system cancer › tracheal cancer › trachea carcinoma › trachea squamous cell carcinoma

Related subtypes (2): trachea mucoepidermoid carcinoma, tracheal adenoid cystic carcinoma

Subtypes (1): trachea carcinoma in situ

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04716751	PHASE2	UNKNOWN	Toripalimab Combined With Chemotherapy in Primary Tracheal Squamous Cell Carcinoma

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
TORIPALIMAB	4	1