Tracheal stenosis
disease diseaseOn this page
Summary
Tracheal stenosis (MONDO:0002568) is a disease and 31 clinical trials. Top therapeutic interventions include prednisolone, remimazolam besylate, and carbon dioxide. A subtype of tracheal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 31
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | tracheal stenosis |
| Mondo ID | MONDO:0002568 |
| MeSH | D014135 |
| DOID | DOID:3227 |
| NCIT | C78646 |
| SNOMED CT | 11296007 |
| UMLS | C0040583 |
| MedGen | 21227 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of tracheal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › respiratory system disorder › lower respiratory tract disorder › tracheal disorder › tracheal stenosis
Related subtypes (7): tracheal calcification, chronic obstructive pulmonary disease, tracheitis, laryngotracheoesophageal cleft, isolated tracheo-esophageal fistula, congenital tracheomalacia, trachea neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 31.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 25 |
| PHASE1/PHASE2 | 3 |
| PHASE4 | 1 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02855502 | PHASE4 | COMPLETED | Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients |
| NCT01331863 | PHASE1/PHASE2 | COMPLETED | Airway and/or Pulmonary Vessels Transplantation |
| NCT01977911 | PHASE1/PHASE2 | WITHDRAWN | Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants |
| NCT03130374 | PHASE1/PHASE2 | COMPLETED | Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells |
| NCT05535803 | PHASE2 | UNKNOWN | Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells |
| NCT02949414 | PHASE1 | SUSPENDED | A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells |
| NCT06917222 | Not specified | RECRUITING | Slide Tracheoplasty Versus Tracheal Resection Anastomosis in Acquired Tracheal Stenosis |
| NCT07086729 | Not specified | NOT_YET_RECRUITING | CT-Based Scoring System to Predict Surgical Need in Tracheal Stenosis (TSMAS Study) |
| NCT07191860 | Not specified | NOT_YET_RECRUITING | Paclitaxel-Coated Pulmonary Balloon for the Treatment of Benign Central Airway Stenosis |
| NCT07240259 | Not specified | ENROLLING_BY_INVITATION | Feasibility of Tracheobronchial Reconstruction Using Allogenic Aortic Patch in Children |
| NCT07258784 | Not specified | RECRUITING | RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis |
| NCT07463742 | Not specified | NOT_YET_RECRUITING | Transcriptomic Profile Changes in Benign Tracheal Stenosis: Wedge Resection vs. Radial Incision |
| NCT00583960 | Not specified | WITHDRAWN | Office-based Radial Expansion Balloon Dilation of the Esophagus and Trachea |
| NCT00705848 | Not specified | COMPLETED | Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis |
| NCT01523275 | Not specified | TERMINATED | Study of Mitomycin-C Application in Laryngotracheal Stenosis |
| NCT02620319 | Not specified | SUSPENDED | Biodegradable Stents in the Management of Stenoses of the Large Airways |
| NCT02796326 | Not specified | COMPLETED | Modified Endotracheal Balloon Dilator to Improve Patient Oxygenation and Allow Ventilation During Airway Procedures |
| NCT02961387 | Not specified | UNKNOWN | A Clinical Trial on Effectiveness and Safety of Hydrogen Generator to Treat Dyspnea for the Patients With Tracheal Stenosis: A Randomized, Double-blind and Single-center Clinical Study |
| NCT03411928 | Not specified | UNKNOWN | Endotracheal Dilator to Improve Oxygenation |
| NCT03455881 | Not specified | UNKNOWN | Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients |
| NCT04625400 | Not specified | UNKNOWN | Role of Bronchoscopy in Assessment of Patients With Post-intubation Tracheal Stenosis |
| NCT04674995 | Not specified | COMPLETED | Stent Versus Balloon Dilatation in Patients With Tracheal Benign Stenosis |
| NCT04686721 | Not specified | UNKNOWN | Observational Study for the Evaluation of Tracheal Stenosis in COVID-19 Patients |
| NCT04719845 | Not specified | TERMINATED | DilAtation Versus Endoscopic Laser Resection in Simple Benign trAcheal sTEnosis |
| NCT04850742 | Not specified | UNKNOWN | Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices |
| NCT05028023 | Not specified | UNKNOWN | Tracheal Dilatation in Pediatric Patients With Acquired Tracheal Stenosis, and the Effects of Apneic Oxygenation |
| NCT05317923 | Not specified | COMPLETED | Airway Management During Unusual Tracheal Stenosis |
| NCT05682651 | Not specified | COMPLETED | Relationship Between Post-Intubation Tracheal Stenosis and Covid-19 |
| NCT05835713 | Not specified | WITHDRAWN | Total Intravenous Anesthesia for Rigid Bronchoscopy Using Remimazolam |
| NCT06061380 | Not specified | COMPLETED | Challenges and Management of Post-intubation Tracheal Stenosis |
| NCT06121024 | Not specified | COMPLETED | Long-term Outcomes of Post-intubation Tracheal Stenosis; 7-year Follow-up |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PREDNISOLONE | 4 | 1 |
| REMIMAZOLAM BESYLATE | 4 | 1 |
| CARBON DIOXIDE | 3 | 1 |
Related Atlas pages
- Drugs: Prednisolone, Remimazolam, Carbon Dioxide