Tracheobronchitis

Summary

Tracheobronchitis (MONDO:0021925) is a disease and 14 clinical trials. Top therapeutic interventions include colistimethate sodium, colistin, and piperacillin. A subtype of lower respiratory tract disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 14

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	tracheobronchitis
Mondo ID	MONDO:0021925
ICD-11	1889351414
NCIT	C122784
SNOMED CT	13617004
UMLS	C0040586
MedGen	508208
Is cancer (heuristic)	no

Also known as: tracheobronchitis

Disease family

This is a subtype of lower respiratory tract disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › respiratory system disorder › lower respiratory tract disorder › tracheobronchitis

Related subtypes (4): bronchial disorder, pleural disorder, tracheal disorder, lung disorder

Subtypes (2): bronchitis, tracheitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 14.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	12
PHASE2/PHASE3	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01027832	PHASE2/PHASE3	UNKNOWN	Antibiotic Treatment in Ventilator Associated Tracheobronchitis (VAT)
NCT00396578	PHASE2	COMPLETED	Aerosolized Antibiotics and Respiratory Tract Infection in Patients on Mechanical Ventilation
NCT04987840	Not specified	ENROLLING_BY_INVITATION	A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children
NCT05266066	Not specified	RECRUITING	Ventilator-associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation
NCT06310941	Not specified	NOT_YET_RECRUITING	Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection
NCT01025921	Not specified	COMPLETED	Tracheobronchitis Prevention Trial
NCT01108185	Not specified	COMPLETED	Evaluation of the Treatment With Klacid®SR in Patients With Lower Respiratory Tract Infection
NCT01130883	Not specified	COMPLETED	Evaluation of Effectiveness of the Treatment After Repeated Administration of Klacid®SR
NCT01824719	Not specified	UNKNOWN	A Registry Study on Reduning（a Chinese Medicine Injection）Used in Hospitals in China
NCT03018431	Not specified	UNKNOWN	CT Scan and Lung Ultrasonography to Improve Diagnostic of Ventilation Acquired Pneumonia in ICU
NCT03461692	Not specified	UNKNOWN	A Registry Study of 100 Thousand Cases of Pediatric Patients on Reduning Injection（a Chinese Medicine Injection）Used in Hospitals in China
NCT04505202	Not specified	COMPLETED	Effect of Chlorhexidine-Induced Oral Care on Ventilator-Related Some Respiratory System Complications
NCT05331417	Not specified	UNKNOWN	Bronchoscopic Score for Prediction of Herpes Simplex-virus Type 1 (HSV-1) Reactivation
NCT05960383	Not specified	UNKNOWN	Molecular vs Conventional Microbiologic Diagnosis for Infections in Lung Transplantation

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
COLISTIMETHATE SODIUM	4	1
COLISTIN	4	1
PIPERACILLIN	4	1
CHEMBL2221249	0	1
CHEMBL4793072	0	1
CHEMBL5411808	0	1
CHEMBL6151919	0	1