Transient congenital hypothyroidism

Summary

Transient congenital hypothyroidism (MONDO:0015792) is a disease and 4 clinical trials. A subtype of congenital hypothyroidism — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 4

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	transient congenital hypothyroidism
Mondo ID	MONDO:0015792
Orphanet	178045
ICD-11	592246939
NCIT	C113171
SNOMED CT	119181000119104
UMLS	C3827793
MedGen	820541
GARD	0020142
Is cancer (heuristic)	no

Also known as: hypothyroxinemia of prematurity · THOP · transient hypothyroxinemia of prematurity

Disease family

This is a subtype of congenital hypothyroidism. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › endocrine system disorder › thyroid gland disorder › hypothyroidism › congenital hypothyroidism › transient congenital hypothyroidism

Related subtypes (7): hypothyroidism, congenital, nongoitrous, familial thyroid dyshormonogenesis, Pendred syndrome, permanent congenital hypothyroidism, idiopathic congenital hypothyroidism, Kocher-debre-Semelaigne syndrome, hypothyroidism due to iodide transport defect

Subtypes (2): transient congenital hypothyroidism due to maternal factor, transient congenital hypothyroidism due to neonatal factor

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 4.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	3
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02103998	PHASE3	WITHDRAWN	Study of Thyroid Hormones in Prematures
NCT03493113	Not specified	COMPLETED	EEG Alterations in Preterm Infants With Thyroid Dysfunction
NCT05901623	Not specified	COMPLETED	ASQ Scores of Transient Hypothyroxinemia of Prematurity
NCT06346236	Not specified	COMPLETED	Neurodevelopmental Impact of Treatment in Hypothyroxinaemia of Prematurity.