Trichomonas vaginitis urogenital infection

Summary

Trichomonas vaginitis urogenital infection (MONDO:0005993) is a disease and 16 clinical trials. Top therapeutic interventions include metronidazole, secnidazole, and tinidazole. A subtype of trichomoniasis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 16

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	Trichomonas vaginitis urogenital infection
Mondo ID	MONDO:0005993
MeSH	D014247
DOID	DOID:0050269
ICD-10-CM	A59.0
NCIT	C35083
SNOMED CT	35089004
Anatomy (UBERON)	UBERON:0001008
Is cancer (heuristic)	no

Also known as: Trichomonas vaginalis caused disease of genitourinary system · Trichomonas vaginalis disease of genitourinary system · Trichomonas vaginitis · urogenital infection by Trichomonas vaginalis

Disease family

This is a subtype of trichomoniasis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › parasitic infectious disease › protozoa infectious disease › trichomoniasis › Trichomonas vaginitis urogenital infection

Related subtypes (4): Trichomonas prostatitis, Trichomonas balanoposthitis, Trichomonas cervicitis, Trichomonas tenax infectious disease

Subtypes (2): Trichomonas cystitis, trichomonal vulvovaginitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Metronidazole	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 16.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	8
PHASE2	4
PHASE3	2
PHASE4	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06261840	PHASE4	RECRUITING	Refining Treatment Options for Trichomonas Vaginalis Infection: A Comparative Analysis of Metronidazole and Secnidazole
NCT00140764	PHASE3	COMPLETED	Intravaginal Treatment of Disturbances of Vaginal Flora Among HIV Infected and Uninfected Women in Malawi
NCT04189744	PHASE3	COMPLETED	The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract
NCT05666778	PHASE2	ACTIVE_NOT_RECRUITING	Single Arm Trial of Menstrual Cups Among Economically Vulnerable Women to Reduce Bacterial Vaginosis and STIs
NCT00213018	PHASE2	COMPLETED	Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission
NCT00213031	PHASE2	COMPLETED	Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide
NCT01361048	PHASE2	COMPLETED	Neo-Penotran Forte Vaginal Suppository for Vaginal Trichomoniasis
NCT00213057	PHASE1	COMPLETED	Safety and Acceptability of Carraguard™ Among HIV-negative Couples in Thailand
NCT05383521	Not specified	NOT_YET_RECRUITING	Safety and Efficacy of Two Oral Tinidazole Regimens for Refractory Trichomonas Vaginitis
NCT00682851	Not specified	COMPLETED	A Validation Study of Genzyme Diagnostics OSOM Trichomonas Rapid Test and BVBlue Test
NCT00978848	Not specified	COMPLETED	Non-Invasive Sexually Transmitted Disease Testing in Women Seeking Emergency Contraception or Urine Pregnancy Testing
NCT01874158	Not specified	COMPLETED	DNA Clearance of Uncomplicated Trichomonas Vaginalis Infections in HIV Negative Women
NCT03090802	Not specified	COMPLETED	MAMAS: Mentoring Adolescent Mothers at School
NCT04219605	Not specified	COMPLETED	Evaluation of a Rapid Microscopic Diagnostic System for Different Vaginitis Conditions
NCT06131749	Not specified	COMPLETED	Genital Tract Infections, the Vaginal Microbiome and Gestational Age at Birth Among Pregnant Women in South Africa
NCT06438575	Not specified	COMPLETED	Point of Care Diagnosis of Vaginal Infections

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
METRONIDAZOLE	4	2
SECNIDAZOLE	4	1
TINIDAZOLE	4	1