Trichuriasis

Summary

Trichuriasis (MONDO:0005996) is a disease and 11 clinical trials. Top therapeutic interventions include albendazole, ivermectin, and moxidectin. A subtype of Enoplea infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 11

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	trichuriasis
Mondo ID	MONDO:0005996
EFO	EFO:0007524
MeSH	D014257
DOID	DOID:1252
ICD-10-CM	B79
ICD-11	422746556
NCIT	C128399
SNOMED CT	3752003
UMLS	C5551334
MedGen	1790401
Is cancer (heuristic)	no

Also known as: trichocephaliasis · trichuriasis infection · Trichuris trichiura caused disease or disorder · Trichuris trichiura disease or disorder · Trichuris trichiura infectious disease · whipworm disease · whipworm infection

Disease family

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › parasitic infectious disease › helminthiasis › Nematoda infectious disease › Enoplea infectious disease › trichuriasis

Related subtypes (3): dioctophymiasis, capillariasis, trichinellosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Albendazole, Ivermectin.

Clinical trials & evidence

Clinical trials

Clinical trials: 11.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE3	3
PHASE2	3
PHASE2/PHASE3	2
PHASE4	1
PHASE1	1
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00659997	PHASE4	COMPLETED	Efficacy Albendazole and Levamisole Against STH on Unguja
NCT03527732	PHASE2/PHASE3	COMPLETED	Efficacy and Safety of IVM/ALB Co-administration
NCT04700423	PHASE2/PHASE3	COMPLETED	Efficacy and Safety of MOX/ALB vs. IVM/ALB Co-administration
NCT04726969	PHASE3	COMPLETED	Efficacy and Safety of MOX/ALB Co-administration
NCT06037876	PHASE3	COMPLETED	Efficacy of Ivermectin-albendazole vs Albendazole Alone in School-aged Children Infected With Trichuris Trichiura
NCT06188715	PHASE3	COMPLETED	Efficacy and Safety of Moxidectin-Albendazole Co-administration in SAC
NCT04713787	PHASE2	RECRUITING	A Safety and Efficacy Study of Different Doses of Oxfendazole Compared to a Single Dose of Albendazole to Treat Trichuris Trichiura Infection in Adults
NCT03527745	PHASE2	COMPLETED	Albendazole Dose Finding and Pharmacokinetics in Children and Adults
NCT06184399	PHASE2	COMPLETED	Efficacy, Safety and Acceptability of Ivermectin ODT in PSAC
NCT05706116	PHASE1	RECRUITING	Controlled Human Infection Study of Orally Administered Trichuris Trichiura Eggs in Naïve Adults
NCT00207753	Not specified	COMPLETED	Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ALBENDAZOLE	4	5
IVERMECTIN	4	2
MOXIDECTIN	4	2
LEVAMISOLE	4	1
DEXAMISOLE	2	1
OXFENDAZOLE	2	1
CHEMBL263291	0	2
CHEMBL4082099	0	2
CHEMBL4788951	0	2
CHEMBL4782609	0	2
CHEMBL5280985	0	2