Trophoblastic neoplasm

Summary

Trophoblastic neoplasm (MONDO:0002872) is a cancer and 5 clinical trials. Top therapeutic interventions include pemetrexed. A subtype of neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 5

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	trophoblastic neoplasm
Mondo ID	MONDO:0002872
MeSH	D014328
DOID	DOID:4085
NCIT	C3422
UMLS	C0041182
MedGen	21708
Anatomy (UBERON)	UBERON:0000088
Is cancer (heuristic)	yes

Also known as: neoplasm of trophoblast · trophoblast neoplasm · trophoblast neoplasm (disease) · trophoblast tumor · trophoblast tumour · trophoblastic neoplasm · trophoblastic neoplasm (morphologic abnormality) · trophoblastic neoplasm NOS (morphologic abnormality) · trophoblastic neoplasms · trophoblastic tumor · trophoblastic tumor (qualifier value) · trophoblastic tumour · trophoblastic tumour (qualifier value) · tumor of trophoblast · tumour of trophoblast

Disease family

This is a subtype of neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › trophoblastic neoplasm

Related subtypes (47): pre-malignant neoplasm, endocrine gland neoplasm, giant cell tumor, hematopoietic and lymphoid system neoplasm, skin neoplasm, mesenchymal cell neoplasm, epidural spinal canal neoplasm, skeletal muscle neoplasm, cancer, germ cell tumor, benign neoplasm, upper aerodigestive tract neoplasm, histiocytoma, embryonal neoplasm, head and neck neoplasm, epithelial neoplasm, reproductive system neoplasm, non-seminomatous lesion, odontogenic cyst, phosphaturic mesenchymal tumor, thyroglossal duct cyst, hamartoma, mesenchymoma, mesothelial neoplasm, peritoneal neoplasm, virus associated tumor, nail tumor, respiratory tract neoplasm, spindle cell neoplasm, mixed neoplasm, urinary system neoplasm, cystic neoplasm, childhood neoplasm, melanocytic neoplasm, digestive system neoplasm, nervous system neoplasm, neoplasm of thorax, connective tissue neoplasm, bronchial adenomas/carcinoids childhood, diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, erythroplakia, retroperitoneal neoplasm, cardiovascular neoplasm, dermoid or epidermoid cyst of the central nervous system, connective and soft tissue neoplasm, NTRK fusion positive cancer, RET fusion positive cancer

Subtypes (4): testicular trophoblastic tumor, choriocarcinoma, hydatidiform mole, gestational trophoblastic neoplasm

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 5.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	3
PHASE2	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06638931	PHASE2	RECRUITING	Agnostic Therapy in Rare Solid Tumors
NCT00190918	PHASE2	COMPLETED	A Trial for Patients With Gestational Trophoblastic Disease
NCT00166790	Not specified	UNKNOWN	Detection of Human Chorionic Gonadotropin by Interferometry in Gestational Trophoblastic Disease
NCT00294177	Not specified	UNKNOWN	Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma
NCT03488901	Not specified	UNKNOWN	Chemoresistance of Trophoblastic Tumors

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PEMETREXED	4	1