Tropical endomyocardial fibrosis
diseaseOn this page
Also known as Davies diseaseTEMF
Summary
Tropical endomyocardial fibrosis (MONDO:0019158) is a disease. A subtype of non-familial restrictive cardiomyopathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide) [Orphanet-validated]
- Phenotypes (HPO): 48
Clinical features
Signs & symptoms
Clinical features (HPO)
48 HPO clinical features (Orphanet curated; top 48 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0006685 | Endocardial fibrosis | Obligate (100%) |
| HP:0001723 | Restrictive cardiomyopathy | Very frequent (80-99%) |
| HP:0002094 | Dyspnea | Very frequent (80-99%) |
| HP:0003115 | Abnormal EKG | Very frequent (80-99%) |
| HP:0012378 | Fatigue | Very frequent (80-99%) |
| HP:0001541 | Ascites | Frequent (30-79%) |
| HP:0001640 | Cardiomegaly | Frequent (30-79%) |
| HP:0001678 | Atrioventricular block | Frequent (30-79%) |
| HP:0001945 | Fever | Frequent (30-79%) |
| HP:0002240 | Hepatomegaly | Frequent (30-79%) |
| HP:0003073 | Hypoalbuminemia | Frequent (30-79%) |
| HP:0004326 | Cachexia | Frequent (30-79%) |
| HP:0004395 | Malnutrition | Frequent (30-79%) |
| HP:0006677 | Prolonged QRS complex | Frequent (30-79%) |
| HP:0011675 | Arrhythmia | Frequent (30-79%) |
| HP:0011712 | Right bundle branch block | Frequent (30-79%) |
| HP:0011713 | Left bundle branch block | Frequent (30-79%) |
| HP:0012249 | Abnormal ST segment | Frequent (30-79%) |
| HP:0012398 | Peripheral edema | Frequent (30-79%) |
| HP:0012764 | Orthopnea | Frequent (30-79%) |
| HP:0025077 | Decreased QRS voltage | Frequent (30-79%) |
| HP:0025168 | Left ventricular diastolic dysfunction | Frequent (30-79%) |
| HP:0030950 | Pulmonary venous hypertension | Frequent (30-79%) |
| HP:0031295 | Left atrial enlargement | Frequent (30-79%) |
| HP:0031664 | Systolic heart murmur | Frequent (30-79%) |
| HP:0033114 | Quadruple gallop rhythm | Frequent (30-79%) |
| HP:0000520 | Proptosis | Occasional (5-29%) |
| HP:0001653 | Mitral regurgitation | Occasional (5-29%) |
| HP:0001744 | Splenomegaly | Occasional (5-29%) |
| HP:0001880 | Eosinophilia | Occasional (5-29%) |
| HP:0001907 | Thromboembolism | Occasional (5-29%) |
| HP:0004749 | Atrial flutter | Occasional (5-29%) |
| HP:0004755 | Supraventricular tachycardia | Occasional (5-29%) |
| HP:0005110 | Atrial fibrillation | Occasional (5-29%) |
| HP:0005135 | Abnormal T-wave | Occasional (5-29%) |
| HP:0005180 | Tricuspid regurgitation | Occasional (5-29%) |
| HP:0006690 | Myocardial calcification | Occasional (5-29%) |
| HP:0010741 | Pedal edema | Occasional (5-29%) |
| HP:0011663 | Right ventricular cardiomyopathy | Occasional (5-29%) |
| HP:0012664 | Reduced left ventricular ejection fraction | Occasional (5-29%) |
| HP:0030057 | Autoimmune antibody positivity | Occasional (5-29%) |
| HP:0030149 | Cardiogenic shock | Occasional (5-29%) |
| HP:0030783 | Increased circulating interleukin 6 concentration | Occasional (5-29%) |
| HP:0030848 | Elevated jugular venous pressure | Occasional (5-29%) |
| HP:0031595 | Abnormal P wave | Occasional (5-29%) |
| HP:0031650 | Abnormal atrioventricular valve physiology | Occasional (5-29%) |
| HP:0005145 | Coronary artery stenosis | Very rare (<1-4%) |
| HP:0031601 | P pulmonale | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | tropical endomyocardial fibrosis |
| Mondo ID | MONDO:0019158 |
| Orphanet | 75565 |
| SNOMED CT | 715626008 |
| UMLS | C2882252 |
| MedGen | 909153 |
| GARD | 0018928 |
| Is cancer (heuristic) | no |
Also known as: Davies disease · TEMF
Disease family
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › muscle tissue disorder › cardiomyopathy › intrinsic cardiomyopathy › restrictive cardiomyopathy › non-familial restrictive cardiomyopathy › tropical endomyocardial fibrosis
Related subtypes (6): cardiac sarcoidosis, hypereosinophilic syndrome, wild type ATTR amyloidosis, Loeffler endocarditis, AL amyloidosis, AA amyloidosis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.