Tropical sprue
disease diseaseOn this page
Also known as idiopathic tropical malabsorption syndromepost-infective tropical malabsorptiontropical enteropathytropical steatorrhea
Summary
Tropical sprue (MONDO:0001078) is a disease and 3 clinical trials. Top therapeutic interventions include rifaximin and rotavirus, live attenuated. A subtype of malabsorption syndrome — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 3
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | tropical sprue |
| Mondo ID | MONDO:0001078 |
| MeSH | D013182 |
| DOID | DOID:10607 |
| ICD-10-CM | K90.1 |
| ICD-11 | 316377284 |
| NCIT | C45428 |
| SNOMED CT | 47384003 |
| UMLS | C0038054 |
| MedGen | 21300 |
| Is cancer (heuristic) | no |
Also known as: idiopathic tropical malabsorption syndrome · post-infective tropical malabsorption · tropical enteropathy · tropical steatorrhea
Disease family
This is a subtype of malabsorption syndrome. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › malabsorption syndrome › tropical sprue
Related subtypes (8): intestinal disaccharidase deficiency, celiac disease, blind loop syndrome, hereditary folate malabsorption, lysine malabsorption syndrome, idiopathic malabsorption due to bile acid synthesis defects, autoimmune enteropathy, lactose intolerance
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 3.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE3 | 1 |
| PHASE1 | 1 |
| Not specified | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01375647 | PHASE3 | COMPLETED | Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in Bangladesh |
| NCT01571505 | PHASE1 | COMPLETED | Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in INDIA (PROVIDE) |
| NCT00858988 | Not specified | COMPLETED | Trial of Rifaximin in the Treatment of Tropical Enteropathy |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| RIFAXIMIN | 4 | 1 |
| ROTAVIRUS, LIVE ATTENUATED | 4 | 1 |
Related Atlas pages
- Drugs: Rifaximin, Rotavirus, Live Attenuated