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Atlas / Disease / Tularemia

Tularemia

disease
On this page

Also known as Deerfly feverFrancisella tularensis caused disease or disorderFrancisella tularensis disease or disorderFrancisella tularensis infectionFrancisella tularensis infectious diseaselemming feverOhara diseasePahvant Valley plaguerabbit feverYatobyo (Japan)

Summary

Tularemia (MONDO:0018077) is a disease (an umbrella term covering 6 Mondo subtypes) and 5 clinical trials. A subtype of primary bacterial infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Prevalence: 1-9 / 100 000 (Europe) [Orphanet-validated]
  • Umbrella term: 6 Mondo subtypes
  • Phenotypes (HPO): 38
  • Clinical trials: 5

Clinical features

Epidemiology

Prevalence records

26 prevalence record(s), Orphanet, top 20 (validated / broadest geography first):

TypeClassValueGeographyValidation
Annual incidence1-9 / 1 000 0000.2EuropeValidated
Point prevalence1-9 / 100 0002EuropeValidated
Annual incidence<1 / 1 000 000United KingdomValidated
Annual incidence<1 / 1 000 000NetherlandsValidated
Annual incidence1-9 / 100 0004SwedenValidated
Annual incidence1-9 / 100 0001.27Czech RepublicValidated
Annual incidence1-9 / 100 0009.1FinlandValidated
Annual incidence1-9 / 1 000 0000.1AustriaValidated
Annual incidence<1 / 1 000 0000.005BelgiumValidated
Annual incidence<1 / 1 000 0000.05DenmarkValidated
Annual incidence1-9 / 1 000 0000.3CroatiaValidated
Annual incidence1-9 / 1 000 0000.6BulgariaValidated
Annual incidence<1 / 1 000 0000.075EstoniaValidated
Annual incidence<1 / 1 000 0000.08FranceValidated
Annual incidence<1 / 1 000 0000.02GermanyValidated
Annual incidence<1 / 1 000 0000.035ItalyValidated
Annual incidence1-9 / 1 000 0000.145LatviaValidated
Annual incidence<1 / 1 000 0000.07LithuaniaValidated
Annual incidence<1 / 1 000 0000.01PolandValidated
Annual incidence<1 / 1 000 0000.01RomaniaValidated

Signs & symptoms

Clinical features (HPO)

38 HPO clinical features (Orphanet curated; top 38 by frequency):

HPO IDTermFrequency
HP:0001649TachycardiaFrequent (30-79%)
HP:0001945FeverFrequent (30-79%)
HP:0001974LeukocytosisFrequent (30-79%)
HP:0002090PneumoniaFrequent (30-79%)
HP:0002315HeadacheFrequent (30-79%)
HP:0002829ArthralgiaFrequent (30-79%)
HP:0003326MyalgiaFrequent (30-79%)
HP:0010702Increased circulating antibody levelFrequent (30-79%)
HP:0025143ChillsFrequent (30-79%)
HP:0025406AstheniaFrequent (30-79%)
HP:0000155Oral ulcerOccasional (5-29%)
HP:0000988Skin rashOccasional (5-29%)
HP:0001873ThrombocytopeniaOccasional (5-29%)
HP:0001903AnemiaOccasional (5-29%)
HP:0002098Respiratory distressOccasional (5-29%)
HP:0002113Pulmonary infiltratesOccasional (5-29%)
HP:0002202Pleural effusionOccasional (5-29%)
HP:0002716LymphadenopathyOccasional (5-29%)
HP:0011355Localized skin lesionOccasional (5-29%)
HP:0012735CoughOccasional (5-29%)
HP:0025289Cervical lymphadenopathyOccasional (5-29%)
HP:0025439PharyngitisOccasional (5-29%)
HP:0030833Neck painOccasional (5-29%)
HP:0031983Abnormal pulmonary thoracic imaging findingOccasional (5-29%)
HP:0000388Otitis mediaVery rare (<1-4%)
HP:0000509ConjunctivitisVery rare (<1-4%)
HP:0000707Abnormality of the nervous systemVery rare (<1-4%)
HP:0000708Atypical behaviorVery rare (<1-4%)
HP:0001287MeningitisVery rare (<1-4%)
HP:0001289ConfusionVery rare (<1-4%)
HP:0012219Erythema nodosumVery rare (<1-4%)
HP:0030049Brain abscessVery rare (<1-4%)
HP:0030953Conjunctival hyperemiaVery rare (<1-4%)
HP:0031292Cutaneous abscessVery rare (<1-4%)
HP:0100533Inflammatory abnormality of the eyeVery rare (<1-4%)
HP:0100721Mediastinal lymphadenopathyVery rare (<1-4%)
HP:0200026Ocular painVery rare (<1-4%)
HP:3000033Abnormality of nasopharyngeal adenoidsVery rare (<1-4%)

Identifiers

Disease identifiers

FieldValue
Canonical nametularemia
Mondo IDMONDO:0018077
EFOEFO:1001444
MeSHD014406
Orphanet3392
DOIDDOID:2123
ICD-10-CMA21
NCITC85208
SNOMED CT19265001
UMLSC0041351
MedGen22520
GARD0000396
MedDRA10045146
NORD1803
Is cancer (heuristic)no

Also known as: Deerfly fever · Francisella tularensis caused disease or disorder · Francisella tularensis disease or disorder · Francisella tularensis infection · Francisella tularensis infectious disease · lemming fever · Ohara disease · Pahvant Valley plague · rabbit fever · Yatobyo (Japan)

Disease family

This is a subtype of primary bacterial infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › primary bacterial infectious disease › tularemia

Related subtypes (36): Buruli ulcer disease, sennetsu fever, salmonellosis, pinta disease, chancroid, gonorrhea, anthrax infection, leprosy, botulism, diphtheria, tetanus, bartonellosis, brucellosis, campylobacteriosis, glanders, granuloma inguinale, legionellosis, leptospirosis, listeriosis, Mycobacterium avium complex disease, ornithosis, rhinoscleroma, staphyloenterotoxemia, syphilis, cholera, ehrlichiosis, melioidosis, tuberculosis, plague, Q fever, shigellosis, Lyme disease, relapsing fever, spirillary rat-bite fever, streptobacillary rat-bite fever, Borrelia miyamotoi disease

Subtypes (6): glandular tularemia, typhoidal tularemia, ulceroglandular tularemia, oculoglandular tularemia, gastrointestinal tularemia, pneumonic tularemia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 5.

Phase distribution (across all retrieved trials)

PhaseTrials
PHASE23
Not specified2

Top trials by phase / activity

NCTPhaseStatusTitle
NCT00584844PHASE2COMPLETEDSafety and Immunogenicity Study of a Live Francisella Tularensis Vaccine
NCT00787826PHASE2UNKNOWNContinued Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine
NCT03867162PHASE2WITHDRAWNFY15-14: Tularemia Vaccine Protocol (NDBR Lot 4)
NCT06859619Not specifiedNOT_YET_RECRUITINGSerological Measurement of Montpellier Professionals’ Contacts with Infectious Agents Responsible for Animal-borne Diseases
NCT05300425Not specifiedCOMPLETEDSeroprevalence of Leptospirosis in Val Müstair, Switzerland

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 24

This page pulls from 24 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogardgenccgwasgwas_studyhgncicd10cmmeddramedgenmeshmimmondomondochildmondoparentncitnordorphanetsctidumls