Tumor of duodenum
diseaseOn this page
Also known as duodenal neoplasmduodenal tumorduodenal tumourduodenum neoplasmduodenum neoplasm (disease)duodenum tumorduodenum tumourneoplasm of duodenumneoplasm of the duodenumtumor of the duodenumtumour of the duodenum
Summary
Tumor of duodenum (MONDO:0021375) is a cancer (an umbrella term covering 6 Mondo subtypes) and 19 clinical trials. Top therapeutic interventions include ursodiol, epinephrine, and hydromorphone. A subtype of duodenal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 6 Mondo subtypes
- Clinical trials: 19
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | tumor of duodenum |
| Mondo ID | MONDO:0021375 |
| NCIT | C2995 |
| SNOMED CT | 126833009 |
| UMLS | C0013291 |
| MedGen | 8503 |
| Anatomy (UBERON) | UBERON:0002114 |
| Is cancer (heuristic) | yes |
Also known as: duodenal neoplasm · duodenal tumor · duodenal tumour · duodenum neoplasm · duodenum neoplasm (disease) · duodenum tumor · duodenum tumour · neoplasm of duodenum · neoplasm of the duodenum · tumor of duodenum · tumor of the duodenum · tumour of the duodenum
Disease family
This is a subtype of duodenal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › small intestine disorder › duodenal disorder › tumor of duodenum
Related subtypes (5): duodenal obstruction, duodenitis, duodenal ulcer, biliary dyskinesia, duodenogastric reflux
Subtypes (6): periampullary adenoma, duodenum cancer, ampulla of vater neoplasm, duodenal villous adenoma, benign duodenal neoplasm, duodenal neuroendocrine neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 19.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 14 |
| PHASE2 | 2 |
| PHASE4 | 1 |
| PHASE2/PHASE3 | 1 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05688020 | PHASE4 | UNKNOWN | Tranexamic Acid During Upper GI Endoscopic Resection Procedures |
| NCT00808743 | PHASE2/PHASE3 | COMPLETED | Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis |
| NCT01731821 | PHASE3 | COMPLETED | Nonstented Stump-closed vs Duct-to-Mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy |
| NCT06411795 | PHASE2 | RECRUITING | Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy |
| NCT00487851 | PHASE2 | WITHDRAWN | Comparing Endoscopic Based Stent Strategy Versus Bypass Surgery in Non-resectable Periampullary Cancer |
| NCT04780256 | Not specified | RECRUITING | Endoscopic Resection of Gastrointestinal Neoplasms |
| NCT06993402 | Not specified | ENROLLING_BY_INVITATION | DESI - Düsseldorfer ESD Study |
| NCT07199127 | Not specified | RECRUITING | Duodenal Polyposis Classification in FAP |
| NCT00359320 | Not specified | TERMINATED | A Randomized Trial of Two Surgical Techniques for Pancreaticojejunostomy in Patients Undergoing Pancreaticoduodenectomy |
| NCT00915863 | Not specified | UNKNOWN | Evaluation of Isolated Roux-en-Y Reconstruction After Pancreaticoduodenectomy |
| NCT01698190 | Not specified | UNKNOWN | Comparing the Efficacy of Endoscopic FNA vs FNB in Diagnosing Solid Gastrointestinal Lesions |
| NCT02381249 | Not specified | COMPLETED | The Effect of Satiety Gut Hormone Modulation on Appetitive Drive After Upper Gastrointestinal Surgery |
| NCT02575014 | Not specified | UNKNOWN | Pancreaticoduodenectomy With or Without Preoperative Hyperbaric Oxygen Therapy |
| NCT03065257 | Not specified | UNKNOWN | Endoscopic Resection Multicenter Registry |
| NCT03792048 | Not specified | UNKNOWN | Magnetic Compressive Anastomosis for Biliojejunostomy and Pancreaticojejunostomy During Whipple’s Procedure |
| NCT04151394 | Not specified | COMPLETED | Side-to-side Duodenojejunostomy After Distal Duodenal Resection (DUORESECT) |
| NCT04622098 | Not specified | UNKNOWN | Prevalence of Sub-epithelial Lesions Among Patients Undergoing EGDs in Egypt |
| NCT05428553 | Not specified | UNKNOWN | CSP vs EMR for >6mm Superficial Non-ampullary Duodenal Tumors |
| NCT06630910 | Not specified | COMPLETED | New Technique of Pancreaticojejunostomy During Whipple Operation |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| URSODIOL | 4 | 2 |
| EPINEPHRINE | 4 | 1 |
| HYDROMORPHONE | 4 | 1 |
| IOPAMIDOL | 4 | 1 |
| OCTREOTIDE | 4 | 1 |
| RACEPINEPHRINE | 2 | 1 |
| CHEMBL5409583 | 0 | 1 |
| CHEMBL4759972 | 0 | 1 |
| CHEMBL3350037 | 0 | 1 |
Related Atlas pages
- Drugs: Ursodiol, Epinephrine, Hydromorphone, Iopamidol, Octreotide