Tumor of meninges

Summary

Tumor of meninges (MONDO:0016743) is a cancer (an umbrella term covering 5 Mondo subtypes) and 4 clinical trials. Top therapeutic interventions include methotrexate and mafosfamide. A subtype of central nervous system neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 5 Mondo subtypes
• Clinical trials: 4

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	tumor of meninges
Mondo ID	MONDO:0016743
EFO	EFO:0003851
Orphanet	252025
NCIT	C3229
SNOMED CT	126965008
UMLS	C0025284
MedGen	44353
GARD	0020737
MedDRA	10061282
Anatomy (UBERON)	UBERON:0010743
Is cancer (heuristic)	yes

Also known as: meningeal cluster neoplasm · meningeal cluster neoplasm (disease) · meningeal cluster rare nervous system tumor · meningeal cluster rare nervous system tumour · meningeal cluster tumor · meningeal cluster tumour · meningeal neoplasm · meningeal neoplasms · meningeal tumor · meningeal tumour · meninges neoplasm · meninges tumor · meninges tumour · meningothelial tumor · meningothelial tumour · neoplasm of meningeal cluster · neoplasm of meninges · neoplasm of the meninges · tumor of meningeal cluster · tumor of meninges (+3 more)

Disease family

This is a subtype of central nervous system neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › central nervous system neoplasm › tumor of meninges

Related subtypes (9): central nervous system organ benign neoplasm, autonomic nervous system neoplasm, optic nerve neoplasm, central nervous system cancer, central nervous system germ cell tumor, central nervous system hematopoietic neoplasm, epidural abscess, brain neoplasm, spinal cord neoplasm

Subtypes (5): meningioma, diffuse leptomeningeal melanocytosis, familial multiple meningioma, malignant tumor of meninges, benign neoplasm of meninges

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

1 approved. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Cytarabine	Approved (phase 4)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Pembrolizumab.

Clinical trials & evidence

Clinical trials

Clinical trials: 4.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE1	2
PHASE4	1
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00029523	PHASE4	COMPLETED	DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor
NCT00001251	PHASE1	COMPLETED	Phase I Study of Intrathecal Mafosfamide
NCT00001333	PHASE1	COMPLETED	Phase I Study of Intrathecal Topotecan
NCT06146010	Not specified	RECRUITING	Non Interventional German Leptomeningeal Disease Register

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
METHOTREXATE	4	1
MAFOSFAMIDE	2	1
CHEMBL426	0	1