Tumor of parathyroid gland
diseaseOn this page
Also known as neoplasm of parathyroidneoplasm of parathyroid glandneoplasm of the parathyroidneoplasm of the parathyroid glandparathyroid gland neoplasmparathyroid gland neoplasm (disease)parathyroid gland tumorparathyroid gland tumourparathyroid neoplasmparathyroid tumorparathyroid tumourtumor of parathyroidtumor of the parathyroidtumor of the parathyroid glandtumour of parathyroidtumour of the parathyroidtumour of the parathyroid gland
Summary
Tumor of parathyroid gland (MONDO:0021360) is a cancer and 16 clinical trials. Top therapeutic interventions include edotreotide gallium ga-68, fluorodopa f 18, and lidocaine. A subtype of parathyroid gland disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 16
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | tumor of parathyroid gland |
| Mondo ID | MONDO:0021360 |
| NCIT | C3313 |
| SNOMED CT | 127020005 |
| UMLS | C0030521 |
| MedGen | 10586 |
| Anatomy (UBERON) | UBERON:0001132 |
| Is cancer (heuristic) | yes |
Also known as: neoplasm of parathyroid · neoplasm of parathyroid gland · neoplasm of the parathyroid · neoplasm of the parathyroid gland · parathyroid gland neoplasm · parathyroid gland neoplasm (disease) · parathyroid gland tumor · parathyroid gland tumour · parathyroid neoplasm · parathyroid tumor · parathyroid tumour · tumor of parathyroid · tumor of parathyroid gland · tumor of the parathyroid · tumor of the parathyroid gland · tumour of parathyroid · tumour of the parathyroid · tumour of the parathyroid gland
Disease family
This is a subtype of parathyroid gland disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › endocrine system disorder › parathyroid gland disorder › tumor of parathyroid gland
Related subtypes (3): hypoparathyroidism, hyperparathyroidism, parathyroid hyperplasia
Subtypes (3): familial primary hyperparathyroidism, malignant tumor of parathyroid gland, benign neoplasm of parathyroid gland
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 16.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 12 |
| PHASE4 | 2 |
| PHASE2 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00037518 | PHASE4 | COMPLETED | A Study of an Investigational Medication for Severe Primary Hyperparathyroidism or Parathyroid Cancer |
| NCT04574947 | PHASE4 | COMPLETED | Lidocaine And Neuromonitoring in Thyroid Surgery |
| NCT00001277 | PHASE2 | COMPLETED | Studies of Elevated Parathyroid Activity |
| NCT00896454 | PHASE2 | COMPLETED | Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium |
| NCT01005654 | Not specified | RECRUITING | Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms |
| NCT05556499 | Not specified | NOT_YET_RECRUITING | The Bone-parathyroid Crosstalk in Primary Hyperparathyroidism |
| NCT05997810 | Not specified | RECRUITING | Parathyroid Tumor Clonal Status |
| NCT07043010 | Not specified | NOT_YET_RECRUITING | WHITE CAP: Intra-operative Parathyroid Tissue Sensor (PTS)-Guided Assessment of Parathyroid Viability and Surgical Decision-Making |
| NCT00001394 | Not specified | COMPLETED | Using X-Ray Dye to Locate Hidden Parathyroid Tumors |
| NCT00639405 | Not specified | TERMINATED | Evaluation of MRI and SPECT Fusion Software to Localize Parathyroid Adenomas |
| NCT01776385 | Not specified | COMPLETED | The ISET (Isolation by Size of Epithelial Tumor Cells) and the CellSearch Methods in Malignant Pleural Mesothelioma |
| NCT03046524 | Not specified | COMPLETED | Parathyroid Cancer Versus Atypical Parathyroid Neoplasm; Investigating Their Clinical Characteristics and Biological Behavior |
| NCT04028479 | Not specified | COMPLETED | The Registry of Oncology Outcomes Associated With Testing and Treatment |
| NCT04299425 | Not specified | COMPLETED | Evaluating Impact of NIRAF Detection for Identifying Parathyroid Glands During Parathyroidectomy |
| NCT05022641 | Not specified | COMPLETED | Evaluating Impact of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy |
| NCT05152927 | Not specified | COMPLETED | Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| EDOTREOTIDE GALLIUM GA-68 | 4 | 1 |
| FLUORODOPA F 18 | 4 | 1 |
| LIDOCAINE | 4 | 1 |