Twin to twin transfusion syndrome
diseaseOn this page
Also known as fetal transfusion syndromeFeto-fetal transfusion syndromeFetofetal transfusion syndromefoetal blood loss from foetal haemorrhage into co-twinfoetal haemorrhage into co-twinfoetal transfusion syndromeplacental transfusion syndromestuck Twin syndromeTTTSTwin Anemia Polycythemia Sequencetwin-to-twin transfusion syndromeTwin-Twin transfusion syndrome
Summary
Twin to twin transfusion syndrome (MONDO:0019805) is a disease and 18 clinical trials. A subtype of neonatal anemia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 18
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | twin to twin transfusion syndrome |
| Mondo ID | MONDO:0019805 |
| EFO | EFO:1001221 |
| MeSH | D005330 |
| Orphanet | 95431 |
| DOID | DOID:13576 |
| ICD-11 | 850604370 |
| NCIT | C113824 |
| SNOMED CT | 13404009 |
| UMLS | C2909036 |
| MedGen | 777055 |
| GARD | 0000325 |
| MedDRA | 10058328 |
| NORD | 2021 |
| Is cancer (heuristic) | no |
Also known as: fetal transfusion syndrome · Feto-fetal transfusion syndrome · Fetofetal transfusion syndrome · foetal blood loss from foetal haemorrhage into co-twin · foetal haemorrhage into co-twin · foetal transfusion syndrome · placental transfusion syndrome · stuck Twin syndrome · TTTS · Twin Anemia Polycythemia Sequence · twin-to-twin transfusion syndrome · Twin-Twin transfusion syndrome
Data availability: 2 cell lines.
Disease family
This is a subtype of neonatal anemia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › hematologic disorder › anemia › neonatal anemia › twin to twin transfusion syndrome
Related subtypes (2): anemia of prematurity, kernicterus due to isoimmunization
Subtypes (1): twin reversal arterial perfusion syndrome
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 18.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 18 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT03775954 | Not specified | RECRUITING | Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise |
| NCT05543499 | Not specified | ACTIVE_NOT_RECRUITING | Database of Monochorionic Pregnancies |
| NCT06056635 | Not specified | RECRUITING | A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures |
| NCT06084247 | Not specified | NOT_YET_RECRUITING | The Efficacy of the KARL STORZ Curved Fetoscope and Straight Fetoscope for Laser Photocoagulation of Placental Anastomoses |
| NCT06991400 | Not specified | RECRUITING | Evaluation of Laparotomy With Trans-Amniotic Suture Placement in TTTS Surgery |
| NCT00345852 | Not specified | UNKNOWN | Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion Syndrome |
| NCT01622049 | Not specified | COMPLETED | Selective Laser Photocoagulation of Communicating Vessels in Twin-Twin Transfusion Syndrome |
| NCT02122328 | Not specified | COMPLETED | Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome |
| NCT02506049 | Not specified | COMPLETED | Laser Photocoagulation in Twin to Twin Transfusion Syndrome |
| NCT02611856 | Not specified | COMPLETED | Monochorial-diamniotic Pregnancies Complicated With a Twin-to-twin Syndrome |
| NCT03151915 | Not specified | COMPLETED | Neonatal Outcome for Laser Coagulation in Twin-to-twin-transfusion Syndrome |
| NCT03171909 | Not specified | UNKNOWN | Austrian Registry on the Outcome of Monochorionic Pregnancies |
| NCT03449823 | Not specified | COMPLETED | Renal Artery Dopplers in Twin Twin Transfusion Syndrome |
| NCT03818867 | Not specified | UNKNOWN | Emergency Cerclage in Twin Pregnancies at Imminent Risk of Preterm Birth: an Open-Label Randomised Controlled Trial |
| NCT04140669 | Not specified | TERMINATED | Automated Myocardial Performance Index Using Samsung HERA W10 |
| NCT04432168 | Not specified | UNKNOWN | The TAPS Trial - Fetoscopic Laser Surgery for Twin Anemia Polycythemia Sequence |
| NCT05312814 | Not specified | COMPLETED | Clinical Utility of the Addition of a SNP-based NIPT Zygosity Determination in Twin Pregnancy Management. |
| NCT05495607 | Not specified | COMPLETED | Continous Renal Replacement Therapy With the CARPEDIEM® in a French National Cohort of 25 Neonates and Small Infants |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.