Unilateral hemispheric polymicrogyria

Summary

Unilateral hemispheric polymicrogyria (MONDO:0015099) is a disease. A subtype of unilateral polymicrogyria — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Phenotypes (HPO): 14

Clinical features

Signs & symptoms

Clinical features (HPO)

14 HPO clinical features (Orphanet curated; top 14 by frequency):

HPO ID	Term	Frequency
HP:0001249	Intellectual disability	Very frequent (80-99%)
HP:0001269	Hemiparesis	Very frequent (80-99%)
HP:0002539	Cortical dysplasia	Very frequent (80-99%)
HP:0006872	Cerebral hypoplasia	Very frequent (80-99%)
HP:0006891	Thick cerebral cortex	Very frequent (80-99%)
HP:0006956	Dilation of lateral ventricles	Very frequent (80-99%)
HP:0007359	Focal-onset seizure	Very frequent (80-99%)
HP:0012758	Neurodevelopmental delay	Very frequent (80-99%)
HP:0002069	Bilateral tonic-clonic seizure	Frequent (30-79%)
HP:0011185	EEG with focal epileptiform discharges	Frequent (30-79%)
HP:0012704	Widened subarachnoid space	Frequent (30-79%)
HP:0002123	Generalized myoclonic seizure	Occasional (5-29%)
HP:0012469	Infantile spasms	Occasional (5-29%)
HP:0020220	Focal atonic seizure	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	unilateral hemispheric polymicrogyria
Mondo ID	MONDO:0015099
Orphanet	101071
ICD-11	1318599015
UMLS	C5681804
MedGen	1842283
GARD	0019777
Is cancer (heuristic)	no

Disease family

This is a subtype of unilateral polymicrogyria. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › congenital nervous system disorder › polymicrogyria › unilateral polymicrogyria › unilateral hemispheric polymicrogyria

Related subtypes (1): unilateral focal polymicrogyria

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.