Ureter neoplasm
diseaseOn this page
Also known as neoplasm of the ureterneoplasm of ureterneoplasms of the ureterneoplasms of uretertumor of the uretertumor of uretertumour of the uretertumour of ureterureter neoplasm (disease)ureter tumorureter tumourureteral neoplasmureteral tumorureteral tumour
Summary
Ureter neoplasm (MONDO:0021111) is a cancer and 10 clinical trials. Top therapeutic interventions include enfortumab vedotin, crizotinib, and paclitaxel. A subtype of ureteral disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 10
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | ureter neoplasm |
| Mondo ID | MONDO:0021111 |
| EFO | EFO:0003844 |
| NCIT | C3427 |
| SNOMED CT | 126882009 |
| UMLS | C0041955 |
| MedGen | 12011 |
| Anatomy (UBERON) | UBERON:0000056 |
| Is cancer (heuristic) | yes |
Also known as: neoplasm of the ureter · neoplasm of ureter · neoplasms of the ureter · neoplasms of ureter · tumor of the ureter · tumor of ureter · tumour of the ureter · tumour of ureter · ureter neoplasm · ureter neoplasm (disease) · ureter tumor · ureter tumour · ureteral neoplasm · ureteral tumor · ureteral tumour
Disease family
An umbrella term covering 3 Mondo subtypes.
Classification path: disease › human disease › disease by body system or component › urinary system disorder › ureteral disorder › ureter neoplasm
Related subtypes (7): pyoureter, ureteral obstruction, ureter tuberculosis, vesicoureteral reflux, ureterolithiasis, ureterocele, ureteritis
Subtypes (3): ureter benign neoplasm, ureter cancer, polyp of ureter
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 10.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE2 | 5 |
| Not specified | 3 |
| PHASE1/PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00077688 | PHASE2 | COMPLETED | TOCOSOL(TM) Paclitaxel in Metastatic or Locally Advanced Unresectable Transitional Cell Carcinoma of the Urothelium |
| NCT00101608 | PHASE2 | COMPLETED | Vinflunine in Patients With Locally Advanced or Metastatic Transitional Cell Carcinoma of the Urothelium |
| NCT01328574 | PHASE2 | COMPLETED | TRC105 in Adults With Advanced/Metastatic Urothelial Carcinoma |
| NCT02612194 | PHASE2 | TERMINATED | LCI-GU-URO-CRI-001: Crizotinib in Patients With c-MET or RON-Positive Metastatic Urothelial Cancer |
| NCT03219333 | PHASE2 | COMPLETED | A Study of Enfortumab Vedotin for Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer |
| NCT03288545 | PHASE1/PHASE2 | TERMINATED | A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer |
| NCT05614739 | PHASE1 | RECRUITING | FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3 |
| NCT00994188 | Not specified | UNKNOWN | A Clinical Study of the Living Renal Transplantation With Restored Kidneys Between Family Members |
| NCT02607709 | Not specified | SUSPENDED | Lymphadenectomy in Urothelial Carcinoma |
| NCT05739812 | Not specified | UNKNOWN | The Efficacy and Safety of Chinese Domestic Surgical Robot System in Urological Telesurgery |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ENFORTUMAB VEDOTIN | 4 | 2 |
| CRIZOTINIB | 4 | 1 |
| PACLITAXEL | 4 | 1 |
| VINFLUNINE | 4 | 1 |
| CAROTUXIMAB | 3 | 1 |
| CHEMBL1825138 | 0 | 1 |
| CHEMBL1825141 | 0 | 1 |
Related Atlas pages
- Drugs: Enfortumab Vedotin, Crizotinib, Paclitaxel, Vinflunine, Carotuximab