Ureteral obstruction

Summary

Ureteral obstruction (MONDO:0003329) is a disease and 20 clinical trials. Top therapeutic interventions include tamsulosin and mirabegron. A subtype of ureteral disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 20

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	ureteral obstruction
Mondo ID	MONDO:0003329
MeSH	D014517
DOID	DOID:5199
SNOMED CT	20018005
UMLS	C0041956
MedGen	12012
Is cancer (heuristic)	no

Also known as: ureteral obstruction · ureteral obstruction (disease)

Data availability: 1 HPO phenotype.

Disease family

Classification path: disease › human disease › disease by body system or component › urinary system disorder › ureteral disorder › ureteral obstruction

Related subtypes (7): pyoureter, ureter tuberculosis, vesicoureteral reflux, ureterolithiasis, ureterocele, ureter neoplasm, ureteritis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 20.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	12
PHASE2	5
PHASE4	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00301470	PHASE4	COMPLETED	Functional MR Urography
NCT01741454	PHASE4	COMPLETED	Treatment of Symptoms After Stent Placement for Urinary Tract Obstruction
NCT01788865	PHASE4	UNKNOWN	Efficacy and Safety of a Covered Self-expandable Dual-layered Metallic Mesh Stent (UVENTA) in Ureteral Obstruction
NCT00142064	PHASE2	COMPLETED	A Randomized Control Trial Comparing Single vs. Multiple Application of Lidocaine Analgesia Prior to Urethral Catheterization Procedures
NCT00250406	PHASE2	COMPLETED	Assessment of Drug-eluting Ureteral Stent on Bacterial Adherence and Biofilm Formation
NCT00790686	PHASE2	COMPLETED	Tolerance and Effectiveness of Ureteral Stents MEMOKATH ® 051 in Chronic Strictures of the Ureter
NCT02744430	PHASE2	COMPLETED	Mirabegron as Medical Expulsive Therapy (MET) for Ureteral Stones and Ureteral Stent Pain
NCT04695951	PHASE2	COMPLETED	Efficacy and Safety of Renalof® in the Removal of Calculi Smaller Than 10 mm Located in the Reno-Ureteral Tract
NCT05022199	Not specified	ENROLLING_BY_INVITATION	Use of SPY Fluorescent Angiography to Reduce Ureteroenteric Stricture Rate Following Urinary Diversion
NCT07409870	Not specified	NOT_YET_RECRUITING	An Integrated Multi-omics Study on the Molecular Mechanisms of Ureteral Stricture
NCT00166361	Not specified	COMPLETED	Drainage of Malignant Extrinsic Ureteral Obstruction Using the Memokath Ureteral Stent
NCT00169650	Not specified	COMPLETED	Laparoscopic Pyeloplasty Registry and Database
NCT00199472	Not specified	WITHDRAWN	Comparison of Dynamic Contrast Enhanced CT and Diuretic Renogram in The Evaluation of UPJO
NCT00568724	Not specified	COMPLETED	Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis
NCT01542593	Not specified	COMPLETED	Evaluating Ureteral Length Using Computed Tomography (CT)
NCT02160652	Not specified	UNKNOWN	Ureteral Reimplantation for the Treatment of Extrinsic Malignant Ureteral Obstruction
NCT02419339	Not specified	TERMINATED	Early Infancy Ureteral Reimplantation for Distal Ureteral Obstruction
NCT03266770	Not specified	COMPLETED	The RELIEF™ Ureteral Stent - Assessment of Retrograde Urinary Reflux and Distal Coil Bladder Position
NCT06110299	Not specified	UNKNOWN	Room Air a Safe Alternative to Dye Injection in Ureterography
NCT06801405	Not specified	COMPLETED	Antibiotic Prophylaxis in Percutaneous Nephrostomy Placements and Replacements for Malignant Urinary Tract Obstruction

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
TAMSULOSIN	4	3
MIRABEGRON	4	1