Urinary system neoplasm
diseaseOn this page
Also known as neoplasm of renal systemneoplasm of the urinary systemneoplasm of the urinary tractneoplasm of urinary systemneoplasm of urinary tractrenal system neoplasmrenal system neoplasm (disease)renal system tumorrenal system tumourtumor of renal systemtumor of the urinary systemtumor of the urinary tracttumor of urinary systemtumor of urinary tracttumour of renal systemtumour of the urinary systemtumour of the urinary tracttumour of urinary systemtumour of urinary tract
Summary
Urinary system neoplasm (MONDO:0021066) is a cancer (an umbrella term covering 8 Mondo subtypes) and 5 clinical trials. Top therapeutic interventions include cisplatin, testosterone cypionate, and apatorsen. A subtype of urinary system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 8 Mondo subtypes
- Clinical trials: 5
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | urinary system neoplasm |
| Mondo ID | MONDO:0021066 |
| NCIT | C192666, C3431 |
| SNOMED CT | 126879004 |
| UMLS | C0042076 |
| MedGen | 52949 |
| Anatomy (UBERON) | UBERON:0001008 |
| Is cancer (heuristic) | yes |
Also known as: neoplasm of renal system · neoplasm of the urinary system · neoplasm of the urinary tract · neoplasm of urinary system · neoplasm of urinary tract · renal system neoplasm · renal system neoplasm (disease) · renal system tumor · renal system tumour · tumor of renal system · tumor of the urinary system · tumor of the urinary tract · tumor of urinary system · tumor of urinary tract · tumour of renal system · tumour of the urinary system · tumour of the urinary tract · tumour of urinary system · tumour of urinary tract · urinary system neoplasm (+5 more)
Disease family
This is a subtype of urinary system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › urinary system disorder › urinary system neoplasm
Related subtypes (19): bacteriuria, ureteral disorder, pyuria, urinary tract obstruction, urethral disorder, kidney disorder, urinary bladder disorder, hyperglycinuria, hypercalciuria, absorptive, 2, hypercalciuria, absorptive, 1, megacystis-megaureter syndrome, postorgasmic illness syndrome, congenital urachal anomaly, urothelial hyperplasia, urolithiasis, urinary tract infection, meningitis-retention syndrome, paraneoplastic renal syndrome, idiopathic hypercalciuria
Subtypes (8): benign urinary system neoplasm, urinary bladder neoplasm, malignant urinary system neoplasm, prostate phyllodes tumor, ureter neoplasm, kidney neoplasm, urethra neoplasm, urothelial neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 5.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE2 | 3 |
| PHASE1/PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05544552 | PHASE1/PHASE2 | ACTIVE_NOT_RECRUITING | Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations |
| NCT05785039 | PHASE2 | RECRUITING | A Study of BL-B01D1 in Patients With Multiple Solid Tumors, Including Locally Advanced or Metastatic Urinary System Tumors |
| NCT06427057 | PHASE2 | NOT_YET_RECRUITING | A Study of Cadonilimab（AK104）Combined With Standard Treatment for Function Preservation in Urinary System Tumors |
| NCT01454089 | PHASE2 | COMPLETED | A Phase 2 Study Comparing Chemotherapy in Combination With OGX-427 or Placebo in Patients With Bladder Cancer |
| NCT04731376 | PHASE1 | ACTIVE_NOT_RECRUITING | Perioperative Testosterone Replacement Therapy for the Improvement of Post-Operative Outcomes in Patients With Low Testosterone |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CISPLATIN | 4 | 1 |
| TESTOSTERONE CYPIONATE | 4 | 1 |
| APATORSEN | 2 | 1 |
| APATORSEN SODIUM | -1 | 1 |
Related Atlas pages
- Drugs: Cisplatin, Testosterone Cypionate