Uterine cervix neoplasm
diseaseOn this page
Also known as Cervical neoplasmcervical tumorcervical tumourcervixcervix neoplasmcervix tumorcervix tumourcervix uteri neoplasmcervix uteri tumorcervix uteri tumourneoplasm of cervixneoplasm of cervix uterineoplasm of the cervixneoplasm of the cervix uterineoplasm of the uterine cervixneoplasm of uterine cervixtumor of cervixtumor of cervix uteritumor of the cervixtumor of the cervix uteri
Summary
Uterine cervix neoplasm (MONDO:0021230) is a cancer (an umbrella term covering 5 Mondo subtypes) and 49 clinical trials. Top therapeutic interventions include cisplatin, artesunate, and human papillomavirus, l1 protein virus like particles. A subtype of cervix disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 5 Mondo subtypes
- Clinical trials: 49
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | uterine cervix neoplasm |
| Mondo ID | MONDO:0021230 |
| NCIT | C2940 |
| UMLS | C0007873 |
| MedGen | 40201 |
| Anatomy (UBERON) | UBERON:0000002 |
| Is cancer (heuristic) | yes |
Also known as: Cervical neoplasm · cervical tumor · cervical tumour · cervix · cervix neoplasm · cervix tumor · cervix tumour · cervix uteri neoplasm · cervix uteri tumor · cervix uteri tumour · neoplasm of cervix · neoplasm of cervix uteri · neoplasm of the cervix · neoplasm of the cervix uteri · neoplasm of the uterine cervix · neoplasm of uterine cervix · tumor of cervix · tumor of cervix uteri · tumor of the cervix · tumor of the cervix uteri (+11 more)
Disease family
This is a subtype of cervix disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › uterine disorder › cervix disorder › uterine cervix neoplasm
Related subtypes (8): cervical polyp, hypertrophic elongation of cervix, cervicitis, cervix endometriosis, uterine cervix leukoplakia, cervical incompetence, cervical metaplasia, cervix erosion
Subtypes (5): cervical benign neoplasm, cervical cancer, nabothian cyst, uterine ligament neoplasm, cervical squamous intraepithelial neoplasia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 49.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 22 |
| PHASE2 | 13 |
| PHASE1/PHASE2 | 6 |
| PHASE1 | 5 |
| PHASE3 | 3 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05764044 | PHASE3 | RECRUITING | Adjuvant Chemotherapy in cfHPV-DNA Plasma Positive Patients: A Biomarker In Locally Advanced Cervical Cancer |
| NCT00119509 | PHASE3 | UNKNOWN | The IMAP Study Improving Management of Mildly Abnormal Pap Smears |
| NCT00190528 | PHASE3 | TERMINATED | A Trial of Neoadjuvant Chemotherapy + Surgery vs. Surgery for Bulky Stage I/II Cervical Cancer |
| NCT00188539 | PHASE2 | ACTIVE_NOT_RECRUITING | Cervix: Hypoxia, Interstitial Fluid Pressure and GSH Levels |
| NCT05824494 | PHASE2 | NOT_YET_RECRUITING | Cadonilimab Plus Nab -Paclitaxel for Patients With Recurrent, or Metastatic Cervical Cancer Resistant to Immune Checkpoint Inhibitors |
| NCT00039884 | PHASE2 | UNKNOWN | Will Radiation/Chemotherapy Treatment of Cervical Cancer Work Better With Medication That May Improve Anemia? |
| NCT00069160 | PHASE2 | COMPLETED | Tariquidar and Docetaxel to Treat Patients With Lung, Ovarian, Renal and Cervical Cancer |
| NCT00084123 | PHASE2 | COMPLETED | Healing Touch and Relaxation Therapies in Cervical Cancer Patients |
| NCT00127465 | PHASE1/PHASE2 | COMPLETED | Investigating the Impact of Tailored Reports on Anxiety Amongst Cancer Patients and Their Confidants |
| NCT00152828 | PHASE1/PHASE2 | COMPLETED | Celebrex - Cervix: Celecoxib in the Treatment of Patients With Locally Advanced Carcinoma of the Cervix |
| NCT00178269 | PHASE2 | COMPLETED | Low-Dose Taxotere® (Docetaxel) With Concurrent Radiotherapy For Localized, Inoperable Carcinoma Of The Uterine Cervix |
| NCT00178802 | PHASE2 | UNKNOWN | Chemotherapy With Whole Body Hyperthermia to Treat Resistant Breast, Endometrial, Cervical and Ovarian Cancers |
| NCT00188578 | PHASE1/PHASE2 | COMPLETED | Intensity Modulated Radiation Therapy - Gyne Cancer (GY03.2) |
| NCT00188695 | PHASE1/PHASE2 | COMPLETED | Combidex USPIO - Ultra-small Superparamagnetic Iron Oxide |
| NCT00950261 | PHASE2 | WITHDRAWN | Efficacy Study for Postoperative Chemoradiation Using Triweekly Cisplatin in Cervical Cancer Patients |
| NCT02184975 | PHASE2 | COMPLETED | Cold Knife Conization With and Without Lateral Hemostatic Sutures |
| NCT03293628 | PHASE2 | COMPLETED | Comparing Two Techniques of Haemostasis After Cervical Conization |
| NCT03418480 | PHASE1/PHASE2 | COMPLETED | HARE-40: HPV Anti-CD40 RNA vaccinE |
| NCT04096911 | PHASE2 | UNKNOWN | Combination of PD-1 Monoclonal Antibody and HPV Vaccine in Patients With Cervical Cancer |
| NCT04413890 | PHASE2 | COMPLETED | Comparison of Two Rhythm of Administration of Prostaglandin Gel for Induction of Labor |
| NCT04651127 | PHASE1/PHASE2 | TERMINATED | Anti-PD-1 Antibody Combined With Histone Deacetylase Inhibitor in Patients With Advanced Cervical Cancer |
| NCT04870177 | PHASE2 | COMPLETED | Study of AK112 in the Treatment of Advanced Gynecological Tumors |
| NCT07038369 | PHASE1 | ACTIVE_NOT_RECRUITING | A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations |
| NCT01338051 | PHASE1 | COMPLETED | The Development of a Mother/Child, Screen, Treat and Vaccinate Program in Manchay and Iquitos, Peru |
| NCT03239223 | PHASE1 | COMPLETED | Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection |
| NCT03697226 | PHASE1 | COMPLETED | Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection. |
| NCT06165614 | PHASE1 | COMPLETED | Artesunate Pessaries (Vaginal Inserts) for Cervical Precancer in Kenya |
| NCT04266093 | Not specified | ENROLLING_BY_INVITATION | Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies |
| NCT04403867 | Not specified | RECRUITING | The Role of Micrometastasis and Isolated Tumor Cells (ITCs) in Endometrial and Cervical Cancer. A Multicenter Study. |
| NCT05994300 | Not specified | ACTIVE_NOT_RECRUITING | Moderately Hypofractionated Adaptive Radiotherapy for Cervical Cancer |
| NCT06550583 | Not specified | ACTIVE_NOT_RECRUITING | Screening for Early Cervical Cancer Detection |
| NCT07372248 | Not specified | RECRUITING | Thermal Artifact in Patients Undergoing Conization: A Clinical Study |
| NCT00112307 | Not specified | COMPLETED | Magnetic Resonance Imaging Guided Gynecologic Brachytherapy |
| NCT00124488 | Not specified | COMPLETED | Comparison of Tomotherapy Versus Intensity-modulated Step-and-shoot and Conventional Radiation Treatment Plans for Patients With Locally-advanced Squamous Cell Carcinoma of the Cervix |
| NCT00250055 | Not specified | TERMINATED | Non-Invasive, Real-Time Technology for Diagnosis of Cervical Tissue |
| NCT00288821 | Not specified | COMPLETED | Diagnostic Imaging of Lymph Nodes in Gynaecologic Oncology |
| NCT00298064 | Not specified | WITHDRAWN | Assessment of EGFR Genomic Alterations as Prognostic Markers in Cervical Cancer |
| NCT01524003 | Not specified | COMPLETED | Chinese Cancer Prevention Study(CHICAPS) |
| NCT01605656 | Not specified | COMPLETED | A Mixed-Methods Approach to Understanding Factors Associated With Cervical Cancer Screening Utilization Among Low-Income, HIV-Positive Women |
| NCT01627288 | Not specified | COMPLETED | Integrated Dose Escalation for Advanced, Localized Gynecologic Cancer (The IDEAL - GYN Trial) |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CISPLATIN | 4 | 2 |
| ARTESUNATE | 4 | 1 |
| HUMAN PAPILLOMAVIRUS, L1 PROTEIN VIRUS LIKE PARTICLES | 4 | 1 |
| CADONILIMAB | 3 | 1 |
| IVONESCIMAB | 3 | 1 |
| SINTILIMAB | 3 | 1 |
| TARIQUIDAR | 3 | 1 |
| TUCIDINOSTAT | 3 | 1 |
| CHEMBL2074629 | 0 | 1 |
| CHEMBL4087968 | 0 | 1 |