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Atlas / Disease / Uterine corpus endometrial carcinoma

Uterine corpus endometrial carcinoma

disease
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Also known as body of uterus endometrial carcinoma (disease)endometrial carcinoma (disease) of body of uterus

Summary

Uterine corpus endometrial carcinoma (MONDO:0000553) is a cancer with 1 cohort gene (1 CIViC-evidence somatic driver). Molecularly, EPHA2 Expression confers sensitivity to Dasatinib + Trametinib in Uterine Corpus Endometrial Carcinoma (CIViC Level C); 1 further subtype–drug associations are mapped below.

At a glance

  • Classification: Cancer
  • Cohort genes: 1
  • Precision-medicine evidence (CIViC): 2 subtype–drug associations

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical nameuterine corpus endometrial carcinoma
Mondo IDMONDO:0000553
DOIDDOID:0050939
Anatomy (UBERON)UBERON:0009853
Is cancer (heuristic)yes

Also known as: body of uterus endometrial carcinoma (disease) · endometrial carcinoma (disease) of body of uterus

Disease family

Classification path: disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › reproductive system cancer › female reproductive organ cancer › uterine cancer › uterine carcinoma › endometrial carcinoma › uterine corpus endometrial carcinoma

Related subtypes (6): endometrial transitional cell carcinoma, endometrium carcinoma in situ, endometrium adenocarcinoma, endometrial small cell carcinoma, endometrial squamous cell carcinoma, endometrial undifferentiated carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

Mendelian disease overlap and somatic drivers

GenCC: 0 · Orphanet: 4 · OMIM-shared: 0 · Dual-evidence (GWAS+Mendelian): 0

Somatic driver evidence (intOGen + CIViC, cohort fanout)

GeneintOGen roleCancer typesCIViC
ERBB2ActBLCA,BRCA,CESC,CHOL,COADREAD,EGC,ESCA,ESCC,LMS,LUAD,NSCLC,OVT,PRCC,READ,STAD,UCECCIViC #20

Orphanet rare-disease linkage (cohort genes)

GeneOrphanet IDRare disease
ERBB2Orphanet:213726Serous carcinoma of the corpus uteri
ERBB2Orphanet:2800Extramammary Paget disease
ERBB2Orphanet:388Hirschsprung disease
ERBB2Orphanet:99976Adenocarcinoma of the oesophagus and oesophagogastric junction

Cohort genes → proteins

1 cohort genes, 1 distinct canonical proteins.

Evidence partition

SubsetGenes
civic_only1

Cohort genes (full)

SymbolHGNCEnsemblUniProtNameEvidence
ERBB2HGNC:3430ENSG00000141736P04626Receptor tyrosine-protein kinase erbB-2civic_evidence

Cohort function summary

Lead sentence per gene, UniProt-curated.

SymbolProtein nameFunction (lead sentence)
ERBB2Receptor tyrosine-protein kinase erbB-2Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding.

Protein-family classification

Druggable: 1 · Difficult: 0 · Unknown: 0 · Druggable fraction: 1.0

Family distribution

Cohort families vs a genome-wide background (hypergeometric, BH-FDR; fold = observed/expected). Counts kept; sorted by enrichment, so the catch-all Other/Unknown bucket no longer leads.

FamilyGenesFoldFDR
Kinase127.7×0.036

Per-gene assignment

SymbolFamilyDruggable?ECInterPro (top 3)
ERBB2Kinaseyes2.7.10.1Rcpt_L-dom, Prot_kinase_dom, Ser-Thr/Tyr_kinase_cat_dom

Expression context

Cohort genes with no expression data: 0.

1 cohort gene are a single-cell marker in ≥1 SCXA experiment.

Breadth distribution (Bgee present_calls)

BucketGenes
narrow (1-5 tissues)0
moderate (6-20)0
broad (>20)1
unknown0

Top tissues across cohort

TissueCohort genes
lower esophagus mucosa1
right uterine tube1
sural nerve1

Per-gene tissue summary (top 30)

SymbolBgee breadthFANTOM5 breadthSCXATop tissues
ERBB2276ubiquitousmarkerlower esophagus mucosa, right uterine tube, sural nerve

Protein interactions among cohort

Intra-cohort edges: 0.

Hub genes (top 10 by interactor count)

SymbolInteractor count
ERBB29,659

Structural data

PDB: 1 · AlphaFold-only: 0 · No structure: 0

Cohort genes with PDB structures (top 30)

SymbolUniProtPDB entries
ERBB2P0462663

Function

Pathway analysis

Distinct Reactome pathways touched by cohort: 33. Enrichment computed across 1 evidence-associated genes (1 with Reactome annotation).

Pathways by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 1 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

PathwayCohort genesFoldFDRSample cohort genes
PLCG1 events in ERBB2 signaling12855.0×0.001ERBB2
Drug-mediated inhibition of ERBB2 signaling12855.0×0.001ERBB2
Resistance of ERBB2 KD mutants to trastuzumab12855.0×0.001ERBB2
Resistance of ERBB2 KD mutants to sapitinib12855.0×0.001ERBB2
Resistance of ERBB2 KD mutants to tesevatinib12855.0×0.001ERBB2
Resistance of ERBB2 KD mutants to neratinib12855.0×0.001ERBB2
Resistance of ERBB2 KD mutants to osimertinib12855.0×0.001ERBB2
Resistance of ERBB2 KD mutants to afatinib12855.0×0.001ERBB2
Resistance of ERBB2 KD mutants to AEE78812855.0×0.001ERBB2
Resistance of ERBB2 KD mutants to lapatinib12855.0×0.001ERBB2
Drug resistance in ERBB2 TMD/JMD mutants12855.0×0.001ERBB2
GRB7 events in ERBB2 signaling11903.3×0.001ERBB2
Constitutive Signaling by Overexpressed ERBB21951.7×0.002ERBB2
Downregulation of ERBB2:ERBB3 signaling1815.7×0.002ERBB2
ERBB2 Activates PTK6 Signaling1815.7×0.002ERBB2
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors1761.3×0.002ERBB2
Developmental Lineage of Mammary Stem Cells1761.3×0.002ERBB2
ERBB2 Regulates Cell Motility1713.8×0.002ERBB2
PI3K events in ERBB2 signaling1671.8×0.002ERBB2
Signaling by ERBB2 ECD mutants1671.8×0.002ERBB2
GRB2 events in ERBB2 signaling1634.4×0.002ERBB2
Sema4D induced cell migration and growth-cone collapse1571.0×0.003ERBB2
Developmental Lineage of Mammary Gland Myoepithelial Cells1543.8×0.003ERBB2
SHC1 events in ERBB2 signaling1475.8×0.003ERBB2
Signaling by ERBB2 TMD/JMD mutants1475.8×0.003ERBB2
Developmental Lineage of Mammary Gland Luminal Epithelial Cells1456.8×0.003ERBB2
Signaling by ERBB2 KD Mutants1423.0×0.003ERBB2
Downregulation of ERBB2 signaling1380.7×0.003ERBB2
Signaling by ERBB21346.1×0.003ERBB2
Constitutive Signaling by Aberrant PI3K in Cancer1126.9×0.009ERBB2

GO biological processes by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 1 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

GO termCohort genesFoldFDRSample cohort genes
immature T cell proliferation in thymus13370.4×0.004ERBB2
negative regulation of immature T cell proliferation in thymus12808.7×0.004ERBB2
ERBB2-ERBB4 signaling pathway12808.7×0.004ERBB2
regulation of microtubule-based process11872.4×0.004ERBB2
ERBB2-ERBB3 signaling pathway11685.2×0.004ERBB2
ERBB2-EGFR signaling pathway11685.2×0.004ERBB2
enzyme-linked receptor protein signaling pathway11296.3×0.004ERBB2
Schwann cell development11053.2×0.005ERBB2
neurotransmitter receptor localization to postsynaptic specialization membrane1802.5×0.005ERBB2
motor neuron axon guidance1702.2×0.005ERBB2
positive regulation of MAP kinase activity1648.1×0.005ERBB2
positive regulation of transcription by RNA polymerase I1648.1×0.005ERBB2
positive regulation of Rho protein signal transduction1581.1×0.005ERBB2
regulation of ERK1 and ERK2 cascade1581.1×0.005ERBB2
positive regulation of protein targeting to membrane1561.7×0.005ERBB2
neuromuscular junction development1526.6×0.005ERBB2
peptidyl-tyrosine phosphorylation1421.3×0.005ERBB2
regulation of angiogenesis1421.3×0.005ERBB2
oligodendrocyte differentiation1421.3×0.005ERBB2
semaphorin-plexin signaling pathway1401.2×0.005ERBB2
cellular response to growth factor stimulus1318.0×0.006ERBB2
cellular response to epidermal growth factor stimulus1318.0×0.006ERBB2
positive regulation of cell adhesion1271.8×0.006ERBB2
myelination1251.5×0.006ERBB2
epidermal growth factor receptor signaling pathway1247.8×0.006ERBB2
positive regulation of epithelial cell proliferation1244.2×0.006ERBB2
wound healing1227.7×0.006ERBB2
positive regulation of translation1227.7×0.006ERBB2
phosphatidylinositol 3-kinase/protein kinase B signal transduction1210.7×0.007ERBB2
positive regulation of cell growth1183.2×0.007ERBB2

Therapeutics

Drug target analysis

Approved (phase 4): 1 · Phase ≥3: 1 · Phased (≥1): 1 · Undrugged: 0

Druggability breadth: 1 of 1 evidence-associated genes (100%) have a ChEMBL target (buckets above are over the deeply-mined display cohort).

Genes with an approved drug

The molecule shown is one approved compound that hits the gene — not necessarily a drug of choice or one indicated for this disease.

SymbolExample approved molecule
ERBB2CLOTRIMAZOLE

Top cohort targets by molecule count

SymbolMoleculesMax phase
ERBB2834

Drugs targeting cohort genes (top 30)

MoleculeMax phaseTargets in cohort
CLOTRIMAZOLE4ERBB2
ERLOTINIB HYDROCHLORIDE4ERBB2
PONATINIB4ERBB2
AFATINIB4ERBB2
LAPATINIB DITOSYLATE4ERBB2
SORAFENIB4ERBB2
NERATINIB4ERBB2
IBRUTINIB4ERBB2
AFATINIB DIMALEATE4ERBB2
CABOZANTINIB4ERBB2
DACOMITINIB4ERBB2
DACOMITINIB ANHYDROUS4ERBB2
VANDETANIB4ERBB2
TRIBROMSALAN4ERBB2
BOSUTINIB4ERBB2
BITHIONOL4ERBB2
ASTEMIZOLE4ERBB2
EBASTINE4ERBB2
OSIMERTINIB4ERBB2
BRIGATINIB4ERBB2
ACALABRUTINIB4ERBB2
ZANUBRUTINIB4ERBB2
TUCATINIB4ERBB2
TIRABRUTINIB4ERBB2
PACLITAXEL4ERBB2
LAZERTINIB4ERBB2
HEXACHLOROPHENE4ERBB2
DOXORUBICIN4ERBB2
DASATINIB4ERBB2
ERLOTINIB4ERBB2

Bioactivity and enzyme data

Enzyme cohort genes (≥1 EC): 1.

Cohort genes with ChEMBL bioactivity (full, sorted by assay count)

SymbolAssaysType breakdown
ERBB21,221Binding:1136, Functional:79, ADMET:6

Cohort enzymes (BRENDA EC)

SymbolEC numbersNames
ERBB22.7.10.1receptor protein-tyrosine kinase

Cohort genes with high screening signal

≥100 ChEMBL assays — a studied-ness signal; see Therapeutics for approved-drug status.

SymbolChEMBL assays
ERBB21,221

Pharmacogenomics

Cohort genes with a PharmGKB record: 1; with CPIC/DPWG dosing guidelines: 0.

No cohort gene has a CPIC/DPWG genotype-guided dosing guideline (PharmGKB).

Drug repurposing candidates

30 approved/phased drugs hit cohort targets but don’t yet appear in disease-level clinical trials. Target-inhibition rationale is strongest for cancer driver genes; a bioactivity hit is a screening signal, not a treatment claim.

CompoundMax phaseCohort target (bioactivity)
CLOTRIMAZOLE4ERBB2
ERLOTINIB HYDROCHLORIDE4ERBB2
PONATINIB4ERBB2
AFATINIB4ERBB2
LAPATINIB DITOSYLATE4ERBB2
SORAFENIB4ERBB2
NERATINIB4ERBB2
IBRUTINIB4ERBB2
AFATINIB DIMALEATE4ERBB2
CABOZANTINIB4ERBB2
DACOMITINIB4ERBB2
DACOMITINIB ANHYDROUS4ERBB2
VANDETANIB4ERBB2
TRIBROMSALAN4ERBB2
BOSUTINIB4ERBB2
BITHIONOL4ERBB2
ASTEMIZOLE4ERBB2
EBASTINE4ERBB2
OSIMERTINIB4ERBB2
BRIGATINIB4ERBB2
ACALABRUTINIB4ERBB2
ZANUBRUTINIB4ERBB2
TUCATINIB4ERBB2
TIRABRUTINIB4ERBB2
PACLITAXEL4ERBB2
LAZERTINIB4ERBB2
HEXACHLOROPHENE4ERBB2
DOXORUBICIN4ERBB2
DASATINIB4ERBB2
ERLOTINIB4ERBB2

Druggability pyramid

Cohort genes binned by druggability tier (high → low):

TierDefinitionGenesSymbols
AApproved (phase 4 drug)1ERBB2
BPhased (≥1) drug, not yet approved0
CDruggable family + PDB, no drug0
DDruggable family + AlphaFold only, no drug0
EDifficult family or no structure, no drug0

Undrugged target profiles

0 cohort genes are undrugged. Ranked by ‘starting-point quality’ (assay depth + drugged-partner adjacency).

Clinical trials & evidence

Clinical trials

Clinical trials: 0.

Precision-medicine subtype map (CIViC)

Drug × molecular subtype: 2 predictive associations from 2 curated evidence items.

Molecular subtypeTherapyEffectLevelCIViC
EPHA2 ExpressionDasatinib + TrametinibSensitivity/ResponseCIViC CEID12577
ERBB2 AmplificationAfatinibSensitivity/ResponseCIViC DEID886

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 69

This page pulls from 69 datasets indexed by BioBTree:

alphafoldantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticscellosauruschembl_activitychembl_assaychembl_documentchembl_moleculechembl_targetciviccivic_evidenceclingen_dosageclinical_trialsclinvarctd_gene_interactiondepmapdiamond_similaritydoidefoensemblentrezesm2_similarityfantom5_genefantom5_promotergenccgenerifgogtopdbgtopdb_interactiongwasgwas_studyhgncintactinterprointogenmeshmimmondomondochildmondoparentorphanetpatentpatent_compoundpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assayreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorstring_interactiontranscriptuberonufeatureuniprot