Uterine disorder

Summary

Uterine disorder (MONDO:0002654) is a disease (an umbrella term covering 21 Mondo subtypes) and 26 clinical trials. Top therapeutic interventions include carboplatin, estrogens, conjugated, and pazopanib. A subtype of female reproductive system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 21 Mondo subtypes
• Clinical trials: 26

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	uterine disorder
Mondo ID	MONDO:0002654
MeSH	D014591
DOID	DOID:345
NCIT	C26907
SNOMED CT	12337004
UMLS	C0042131
MedGen	22590
Anatomy (UBERON)	UBERON:0000995
Is cancer (heuristic)	no

Also known as: disease of uterus · disease or disorder of uterus · disorder of uterus · uterine disease · uterine disorder · uterus disease · uterus disease or disorder

Disease family

This is a subtype of female reproductive system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › uterine disorder

Related subtypes (33): ectopic pregnancy, pelvic inflammatory disease, endosalpingiosis, vaginal disorder, prolapse of female genital organ, Allen-Masters syndrome, fallopian tube disorder, vulvar disease, gynatresia, Bartholin duct cyst, ovarian disorder, hymen, imperforate, preterm premature rupture of the membranes, mammary-digital-nail syndrome, Asherman syndrome, uterine cervical aplasia and agenesis, longitudinal vaginal septum, transverse vaginal septum, polycystic ovaries-urethral sphincter dysfunction syndrome, granulomatous mastitis, vaginal atresia, mullerian aplasia, vulvovaginal gingival syndrome, isolated partial vaginal agenesis, female infertility, female reproductive system neoplasm, polyp of vulva, vulval varices, vulvodynia, menstrual cycle-dependent periodic fever, Bartholin’s gland disease, delayed puberty, self-limited, menstrual disorder

Subtypes (21): pyometritis, endometrial disorder, female infertility of uterine origin, uterine inflammatory disease, chronic subinvolution of uterus, adhesions of uterus, cervix disorder, uterine polyp, pelvic congestion syndrome, uterine inversion, placenta disorder, hemometra, parametritis, cordiform uterus, septate uterus, bicornuate uterus, uterine hypoplasia, agenesis and aplasia of uterine body, tumor of uterus, florid cystic endosalpingiosis of the uterus, pregnancy, cornual

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Misoprostol	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 26.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	21
PHASE2	3
PHASE4	1
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02868437	PHASE4	UNKNOWN	Effectiveness of Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Second Trimester Abortion
NCT02682433	PHASE3	UNKNOWN	3D Sonohysterography vs Hysteroscopy: Study for the Evaluation of Intrauterine Abnormalities
NCT00000612	PHASE2	COMPLETED	Soy Estrogen Alternative Study (SEA)
NCT00561795	PHASE2	COMPLETED	Feasibility Study of Pazopanib in Combination With Chemotherapy in Gynaecological Tumors
NCT04184323	PHASE2	WITHDRAWN	SIRT-1 Antagonism for Endometrial Receptivity
NCT04061967	Not specified	RECRUITING	Research Project on Reminders and Self-Sampling Can Increase Participation in Gynecology Cell Sampling - Preventive Examination Against Cervical Cancer.
NCT06656286	Not specified	NOT_YET_RECRUITING	Hysteroscopic Intrauterine Suturing
NCT07478614	Not specified	RECRUITING	Multicenter Observational Cohort Study on the Epidemiology of Therapeutic Strategies in Patients Affected by Adenomyosis
NCT00341458	Not specified	COMPLETED	Breast Cancer in Poland: An Expanded Study to Assess Occupational and Environmental Factors and Interactions With Genetics
NCT00793260	Not specified	COMPLETED	Deep Dive Randomized Control Trial
NCT02390804	Not specified	COMPLETED	Postoperative Pain After Total Laparoscopic Hysterectomy: a Comparison of Single-port and Three-port Laparoscopy
NCT02631837	Not specified	COMPLETED	Hysterectomy by Transabdominal Laparoscopy or NOTES
NCT03093675	Not specified	COMPLETED	Robotic Assisted Surgery for Treatment of Gynecological Diseases: Pilot Study
NCT03827824	Not specified	TERMINATED	Virtual Reality on Perception of Pain and Anxiety by Hysteroscopy
NCT03861195	Not specified	COMPLETED	Comparative Prospective Data Collection in Connection With Two Different Treatment Methods: Robotic Assisted Laparoscopy and Conventional Laparoscopy
NCT04436354	Not specified	COMPLETED	The Effect of Trendelenburg Lithotomy Position on Pain and Procedural Time During Vaginoscopic Office Hysteroscopy
NCT04571671	Not specified	COMPLETED	Do müllerian Anomalies Affect Embryo Implantation?
NCT04679675	Not specified	COMPLETED	Self-Testing Options in the Era of Primary HPV Screening for Cervical Cancer Trial
NCT04808583	Not specified	COMPLETED	Uterine Artery Ligation at Origin in Total Laparscopic Hystrectomy
NCT05102032	Not specified	UNKNOWN	Impact of a Minimally Invasive Approach to Laparoscopic Hysterectomy on Postoperative Recovery
NCT05453006	Not specified	COMPLETED	HPV Self-Sampling in Somali Women (Isbaar Project)
NCT05533710	Not specified	UNKNOWN	Comparison Between Erector Spinae Plane Block and Transversus Abdominis Plane Block on Postoperative Analgesia After Total Abdominal Hysterectomy
NCT05613816	Not specified	COMPLETED	Prospective Data Collection to Compare RAL for Hysterectomies and Other Indications in to Conventional Laparoscopy
NCT05823935	Not specified	UNKNOWN	Laparoscopic Versus Vaginal Cuff Closure During LH in Benign Gynecological Lesions
NCT06019039	Not specified	COMPLETED	Power Doppler Ultrasonography in Localization of Epidural Catheter
NCT07046949	Not specified	COMPLETED	Anterior Quadratus Lumborum Block as a Component of Multimodal Analgesia for Abdominal Hysterectomies

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CARBOPLATIN	4	1
ESTROGENS, CONJUGATED	4	1
PAZOPANIB	4	1
EX-527	2	1
CHEMBL4068768	0	1
CHEMBL4171277	0	1
CHEMBL420311	0	1