Vaginal cancer
diseaseOn this page
Also known as cancer of vaginamalignant neoplasm of the vaginamalignant neoplasm of vaginamalignant tumor of the vaginamalignant tumor of vaginamalignant tumour of the vaginamalignant tumour of vaginamalignant vagina neoplasmmalignant vagina tumormalignant vagina tumourmalignant vaginal neoplasmmalignant vaginal tumormalignant vaginal tumourvagina cancervagina neoplasmvaginal tumorvaginal tumour
Summary
Vaginal cancer (MONDO:0001402) is a cancer (an umbrella term covering 5 Mondo subtypes) and 103 clinical trials. Top therapeutic interventions include paclitaxel, human papillomavirus, l1 protein virus like particles, and belzutifan. A subtype of female reproductive organ cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 5 Mondo subtypes
- Clinical trials: 103
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | vaginal cancer |
| Mondo ID | MONDO:0001402 |
| MeSH | D014625 |
| DOID | DOID:119 |
| ICD-10-CM | C52 |
| ICD-11 | 798353632 |
| NCIT | C7410 |
| SNOMED CT | 363445000 |
| UMLS | C0042237 |
| MedGen | 12040 |
| Anatomy (UBERON) | UBERON:0000996 |
| Is cancer (heuristic) | yes |
Also known as: cancer of vagina · malignant neoplasm of the vagina · malignant neoplasm of vagina · malignant tumor of the vagina · malignant tumor of vagina · malignant tumour of the vagina · malignant tumour of vagina · malignant vagina neoplasm · malignant vagina tumor · malignant vagina tumour · malignant vaginal neoplasm · malignant vaginal tumor · malignant vaginal tumour · vagina cancer · vagina neoplasm · vaginal tumor · vaginal tumour
Disease family
This is a subtype of female reproductive organ cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › reproductive system cancer › female reproductive organ cancer › vaginal cancer
Related subtypes (8): vulva cancer, fallopian tube cancer, uterine cancer, adenocarcinofibroma, endometrioid adenocarcinoma, adenosarcoma, ovarian cancer, gestational choriocarcinoma
Subtypes (5): vagina sarcoma, vaginal adenosarcoma, vaginal carcinoma, vaginal germ cell malignant tumor, malignant vaginal mixed epithelial and mesenchymal neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 103.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 53 |
| PHASE2 | 19 |
| PHASE1 | 15 |
| PHASE3 | 12 |
| PHASE1/PHASE2 | 4 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04422366 | PHASE3 | RECRUITING | Evaluate the Efficacy, Immunogenicity and Safety of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females |
| NCT04895020 | PHASE3 | RECRUITING | Immunobridging Study of 9-valent Human Papillomavirus Recombinant Vaccine in Chinese Females Aged 9 to 19 Years |
| NCT05027776 | PHASE3 | RECRUITING | Immunogenicity and Safety of Quadrivalent HPV Vaccine in Healthy Chinese Female Subjects Aged 9 to 19 Years |
| NCT00003267 | PHASE3 | COMPLETED | Pelvic Drains After Radical Hysterectomy in Treating Patients With Uterine, Cervical, or Vaginal Cancer |
| NCT00033605 | PHASE3 | COMPLETED | Octreotide in Preventing Diarrhea in Patients Who Are Undergoing Radiation Therapy to the Pelvis |
| NCT00543543 | PHASE3 | COMPLETED | Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001) |
| NCT00943722 | PHASE3 | COMPLETED | A Study of V503 (A Multivalent Human Papillomavirus [HPV] L1 Virus-Like Particle [VLP] Vaccine) in Preadolescents and Adolescents (V503-002) |
| NCT01047345 | PHASE3 | COMPLETED | A Study of V503, a 9-valent Human Papillomavirus (9vHPV) Vaccine in Females 12-26 Years of Age Who Have Previously Received GARDASIL™ (V503-006) |
| NCT01087268 | PHASE3 | UNKNOWN | Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer |
| NCT03158220 | PHASE3 | COMPLETED | Immunogenicity and Tolerability of Broad Spectrum Human Papillomavirus (HPV) Vaccine in Adult and Young Adult Women (V503-004) |
| NCT04425291 | PHASE3 | COMPLETED | Evaluate the Immunogenicity and Safety of 4-valent and 9-valent HPV Recombinant Vaccine in Chinese Healthy Females |
| NCT05372016 | PHASE3 | COMPLETED | Evaluate the Immunogenicity and Safety of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females |
| NCT04708470 | PHASE1/PHASE2 | ACTIVE_NOT_RECRUITING | A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers |
| NCT05639972 | PHASE1/PHASE2 | RECRUITING | E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers |
| NCT05686226 | PHASE2 | RECRUITING | E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers |
| NCT05979610 | PHASE2 | RECRUITING | Using Reiki Therapy to Improve Symptoms Associated With Brachytherapy in Patients With Gynecological Malignancies |
| NCT06023862 | PHASE2 | RECRUITING | A Three-arm Randomized Phase II Study of Dostarlimab Alone or With Bevacizumab Versus Nonplatinum Chemotherapy in Recurrent Gynecological Clear Cell Carcinoma: DOVE (APGOT-OV7/ ENGOT-ov80 Study) |
| NCT06677190 | PHASE2 | RECRUITING | Belzutifan in Recurrent Clear Cell Carcinoma of Gynecologic Origin |
| NCT00002562 | PHASE2 | COMPLETED | Paclitaxel in Treating Patients With Advanced, Refractory, or Recurrent Cervical or Vaginal Cancer |
| NCT00005941 | PHASE2 | COMPLETED | Peripheral Stem Cell Transplant, White Blood Cell Infusions, Chemotherapy, and Radiation Therapy in Treating Patients With Recurrent Metastatic Cervical or Vaginal Cancer |
| NCT00275353 | PHASE2 | COMPLETED | Effectiveness of an Individualized Symptom Education Program (ISEP) |
| NCT00381888 | PHASE2 | COMPLETED | Fondaparinux in Preventing Blood Clots in Patients Undergoing Surgery for Gynecologic Cancer |
| NCT00520598 | PHASE2 | COMPLETED | Broad Spectrum HPV (Human Papillomavirus) Vaccine in 16 to 26 Year Old Women (V505-001) |
| NCT00545792 | PHASE2 | COMPLETED | Safety Study Of Avastin And Pelvic Radiation In Women With Recurrent Gynecological Cancers |
| NCT00551187 | PHASE2 | COMPLETED | A Study to Evaluate Tolerability and Immunogenicity of V504 Administered Concomitantly With GARDASIL (V504-001)(COMPLETED) |
| NCT00905658 | PHASE2 | UNKNOWN | Nutritional Supplements in Improving Quality of Life During First-Line Chemotherapy in Patients With Metastatic Gynecological Cancer |
| NCT00941070 | PHASE2 | COMPLETED | Triapine, Cisplatin, and Radiation Therapy in Treating Patients With Cervical Cancer or Vaginal Cancer |
| NCT01079832 | PHASE2 | COMPLETED | Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies |
| NCT01097239 | PHASE1/PHASE2 | WITHDRAWN | Examining the Role of Transrectal High Intensity Focused Ultrasound (HIFU) in Rectal Pelvic Cancer |
| NCT01399658 | PHASE2 | COMPLETED | Image-Guided Gynecologic Brachytherapy |
| NCT01585428 | PHASE2 | COMPLETED | Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers |
| NCT01764802 | PHASE2 | COMPLETED | Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer |
| NCT02280811 | PHASE1/PHASE2 | COMPLETED | T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers |
| NCT03439085 | PHASE2 | TERMINATED | DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated Cancers |
| NCT04066894 | PHASE2 | TERMINATED | Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study |
| NCT03634267 | PHASE1 | ACTIVE_NOT_RECRUITING | MRI-Guided Brachytherapy in Treating Participants With HPV-Associated Stage IB2-IVA Cervical or Stage II-IVA Vaginal Cancer |
| NCT03968406 | PHASE1 | RECRUITING | Talazoparib and Radiation Therapy in Treating Patients With Locally Recurrent Gynecologic Cancers |
| NCT06544720 | PHASE1 | RECRUITING | SCG142 TCR-T Cells for Human Papillomavirus-Associated Carcinomas |
| NCT00002949 | PHASE1 | COMPLETED | Vinorelbine and Paclitaxel Plus Radiation Therapy in Treating Patients With Advanced Cancer Arising in the Pelvis |
| NCT00004074 | PHASE1 | COMPLETED | Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PACLITAXEL | 4 | 4 |
| HUMAN PAPILLOMAVIRUS, L1 PROTEIN VIRUS LIKE PARTICLES | 4 | 2 |
| BELZUTIFAN | 4 | 1 |
| DOSTARLIMAB | 4 | 1 |
| FLUDEOXYGLUCOSE F 18 | 4 | 1 |
| FONDAPARINUX SODIUM | 4 | 1 |
| OCTREOTIDE ACETATE | 4 | 1 |
| VINORELBINE TARTRATE | 4 | 1 |
| TRIAPINE | 3 | 2 |
| BINTRAFUSP ALFA | 3 | 1 |
| ENTINOSTAT | 3 | 1 |
| EDODEKIN ALFA | 2 | 1 |
| CHEMBL4084635 | 0 | 1 |
| CHEMBL3764816 | 0 | 1 |
| CHEMBL5724798 | 0 | 1 |