Vaginal neoplasm

Summary

Vaginal neoplasm (MONDO:0021050) is a cancer (an umbrella term covering 7 Mondo subtypes) and 11 clinical trials. Top therapeutic interventions include bevacizumab and dostarlimab. A subtype of vaginal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 7 Mondo subtypes
• Clinical trials: 11

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	vaginal neoplasm
Mondo ID	MONDO:0021050
EFO	EFO:1001447
NCIT	C3437
SNOMED CT	126921000
UMLS	C0042258
MedGen	22608
Anatomy (UBERON)	UBERON:0000996
Is cancer (heuristic)	yes

Also known as: neoplasm of the vagina · neoplasm of vagina · tumor of the vagina · tumor of vagina · tumour of the vagina · tumour of vagina · vagina neoplasm · vagina neoplasm (disease) · vagina tumor · vagina tumour · vaginal neoplasm · vaginal tumor · vaginal tumour

Disease family

This is a subtype of vaginal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › vaginal disorder › vaginal neoplasm

Related subtypes (5): vaginitis, vaginal discharge, leukoplakia of vagina, polyp of vagina, vaginismus

Subtypes (7): benign vaginal neoplasm, vaginal cancer, vaginal glandular neoplasm, vaginal squamous tumor, endometrioid stromal and related neoplasms of the vagina, vaginal melanoma, extraovarian Brenner tumor of the vagina

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 11.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE2	2
PHASE3	1
PHASE1/PHASE2	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03546842	PHASE3	COMPLETED	Safety and Immunogenicity Study of V503 (GARDASIL™9, 9vHPV Vaccine) Administered to 9- to 26-Year-Old Females and Males in Vietnam (V503-017)
NCT06023862	PHASE2	RECRUITING	A Three-arm Randomized Phase II Study of Dostarlimab Alone or With Bevacizumab Versus Nonplatinum Chemotherapy in Recurrent Gynecological Clear Cell Carcinoma: DOVE (APGOT-OV7/ ENGOT-ov80 Study)
NCT06638931	PHASE2	RECRUITING	Agnostic Therapy in Rare Solid Tumors
NCT00188578	PHASE1/PHASE2	COMPLETED	Intensity Modulated Radiation Therapy - Gyne Cancer (GY03.2)
NCT05787535	PHASE1	UNKNOWN	HRYZ-T101 TCR-T Cell for HPV-18 Positive Advanced Solid Tumor
NCT06514235	Not specified	RECRUITING	Image-guided Brachytherapy for Vaginal Cancer (EMBRAVE)
NCT00112307	Not specified	COMPLETED	Magnetic Resonance Imaging Guided Gynecologic Brachytherapy
NCT00391664	Not specified	UNKNOWN	Questionnaire Study for Gynecological Cancer Survivors
NCT02786524	Not specified	COMPLETED	Effect of Outpatient Symptom Management on Gynecologic Oncology Patients Receiving Chemotherapy
NCT04351139	Not specified	COMPLETED	Impact of the COVID-19 Pandemic in Gynecological Oncology
NCT05925361	Not specified	UNKNOWN	Peritoneum Vaginoplasty; Implementation According to IDEAL Framework

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
BEVACIZUMAB	4	1
DOSTARLIMAB	4	1