Vaginismus

Summary

Vaginismus (MONDO:0021723) is a disease and 17 clinical trials. Top therapeutic interventions include onabotulinumtoxina. A subtype of vaginal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 17

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	vaginismus
Mondo ID	MONDO:0021723
MeSH	D052065
ICD-10-CM	N94.2
UMLS	C2004487
MedGen	412150
Is cancer (heuristic)	no

Also known as: myalgia of pelvic floor · vaginismus

Disease family

This is a subtype of vaginal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › vaginal disorder › vaginismus

Related subtypes (5): vaginitis, vaginal discharge, leukoplakia of vagina, vaginal neoplasm, polyp of vagina

Subtypes (1): psychologic vaginismus

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 17.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	14
PHASE3	2
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06564883	PHASE3	NOT_YET_RECRUITING	Hydration and Acceptability of the Genital and Skin Mucosa of a Vaginal Moisturizer in Menopausal Women
NCT00638066	PHASE3	UNKNOWN	Botulinum Toxin Injection for Treatment of Vaginismus
NCT01352546	PHASE1	COMPLETED	Botox Injection for Treatment of Vaginismus
NCT06397885	Not specified	ACTIVE_NOT_RECRUITING	Prospective on Market Patient-reported Outcomes for Milli
NCT06486896	Not specified	NOT_YET_RECRUITING	Effect of Adding Interferential Current to Pelvic Floor Muscle Training on Vaginismus
NCT06840314	Not specified	RECRUITING	VIBRating vs Traditional Therapy for Treatment of ENTry Dyspareunia
NCT06923306	Not specified	RECRUITING	Virtual Reality Exposure for Vaginismus: A Replicated Single-Case Design
NCT00281372	Not specified	COMPLETED	Sexual Dysfunction and Dental Care
NCT01530113	Not specified	UNKNOWN	Childhood Sexual Abuse, Vaginismus and Labor Dystocia
NCT01859507	Not specified	COMPLETED	Injection of Botox in the Perineal Muscles in Resistant Cases of Vaginal Spasm
NCT02430038	Not specified	COMPLETED	Transperineal Ultrasound to Assess the Progress of Labour
NCT03176069	Not specified	COMPLETED	Evaluation and Comparison of Women Pelvic Floor With and Without Sexual Dysfunction (Vaginismus)
NCT04436172	Not specified	COMPLETED	Spinal Anesthesia Facilitated Sexual Intercourse As A Treatment Option For Vaginismus
NCT04635345	Not specified	COMPLETED	Feasibility of Use of Vibrators With Vaginal Dilators for Vaginismus. (Vibrator Therapy and Dilators in Vaginismus)
NCT05529407	Not specified	UNKNOWN	Trial of SVTampons vs Glass Vaginal Dilators in Treatment of Vaginismus
NCT05926752	Not specified	UNKNOWN	Photobiomodulation for Myofascial Pelvic Pain
NCT07588724	Not specified	COMPLETED	Effectiveness of Cognitive Behavioral Therapy on Psychological Distress and Problem-Solving Skills in Women With Vaginismus

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ONABOTULINUMTOXINA	4	1