Varicocele
diseaseOn this page
Also known as scrotal varicesscrotum varicose diseasevaricose disease of scrotum
Summary
Varicocele (MONDO:0001498) is a disease and 39 clinical trials. Top therapeutic interventions include levobupivacaine. A subtype of pelvic varices — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- ClinVar variants: 1
- Clinical trials: 39
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | varicocele |
| Mondo ID | MONDO:0001498 |
| MeSH | D014646 |
| DOID | DOID:12337 |
| ICD-10-CM | I86.1 |
| ICD-11 | 315302008 |
| SNOMED CT | 46871008 |
| UMLS | C0042341 |
| MedGen | 22619 |
| Anatomy (UBERON) | UBERON:0001300 |
| Is cancer (heuristic) | no |
Also known as: scrotal varices · scrotum varicose disease · varicose disease of scrotum
Data availability: 1 ClinVar variant.
Disease family
This is a subtype of pelvic varices. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › vein disorder › varicose disease › pelvic varices › varicocele
Related subtypes (2): hemorrhoid, vulval varices
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
ClinVar germline variants
1 retrieved; paginated sample, class counts are floors:
1 uncertain significance
| ClinVar | Variant (HGVS) | Gene | Classification | Review |
|---|---|---|---|---|
| 267936 | 46;XY;t(12;14)(q15;q13)mat | Uncertain significance | criteria provided, single submitter |
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 39.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 36 |
| PHASE4 | 2 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01463787 | PHASE4 | COMPLETED | Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled Trial |
| NCT02719093 | PHASE4 | UNKNOWN | Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery |
| NCT01259258 | PHASE2 | COMPLETED | Dye Assisted Lymphatic Sparing Subinguinal Varicocelectomy |
| NCT06718426 | Not specified | RECRUITING | Evaluation of Fertitonex Effects on Semen Parameters in Clinical Varicocele Patient. |
| NCT06743932 | Not specified | NOT_YET_RECRUITING | A Prospective Cohort Study of Combined Subinguinal Varicocele Ligation and Sclerotherapy |
| NCT07065695 | Not specified | NOT_YET_RECRUITING | Microscopic Varicocele Bypass Versus Ligation |
| NCT07263009 | Not specified | NOT_YET_RECRUITING | Reflux Flow Volume Impact on Semen Parameters Pre and Post Varicocelectomy |
| NCT07517952 | Not specified | NOT_YET_RECRUITING | Intratesticular Artery Resistive Index Changes After Varicocelectomy |
| NCT07605351 | Not specified | NOT_YET_RECRUITING | Selective Extended Venous Stripping Versus Standard Microsurgical Varicocelectomy for Varicocele-Related Male Infertility |
| NCT00044369 | Not specified | COMPLETED | Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele |
| NCT00639899 | Not specified | COMPLETED | The Effect of Spermatic Vein Embolization on Prostatic Hypertrophy |
| NCT00961558 | Not specified | TERMINATED | Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of Varicocelectomy |
| NCT01296230 | Not specified | TERMINATED | Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality? |
| NCT02006316 | Not specified | COMPLETED | Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than Infertility |
| NCT02033863 | Not specified | UNKNOWN | Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromE |
| NCT02092311 | Not specified | COMPLETED | Assessing the Rates of Major Complications in Combined Mini-incision Microscopic Varicocelectomy |
| NCT02304575 | Not specified | UNKNOWN | Quality of Life Among Testicular Cancer Survivors |
| NCT02335385 | Not specified | COMPLETED | Single Incision Laparoscopic Varicocelectomy |
| NCT02401087 | Not specified | COMPLETED | The Anaesthesiological Approach to Varicocele Correction in Outpatients Setting: an Observational Analysis |
| NCT02695199 | Not specified | UNKNOWN | Doppler Ultrasound Assisted Varicocelectomy Improve Sperm Qualities |
| NCT02722187 | Not specified | UNKNOWN | The Role of Microsurgery in Surgical Treatment of Varicocele. |
| NCT02983383 | Not specified | COMPLETED | Effect of TAP Block for Postoperative Pain Control After Varicocele Operations. |
| NCT02983656 | Not specified | COMPLETED | Analysis on AEFI Surveillance Data for Live Attenuated Varicella Vaccine |
| NCT03079609 | Not specified | UNKNOWN | The Search for Viral and Bacterial Etiology of Varicocele |
| NCT03090438 | Not specified | UNKNOWN | IVF Outcomes After Varicocele Repair |
| NCT03281915 | Not specified | UNKNOWN | the Effect of Different Modialites of Varicocelectomy on Semen Parameters in Patient With Normal Semen Analysis |
| NCT03341897 | Not specified | UNKNOWN | Varicocele Treatement by Endovasculer Embolization |
| NCT03477149 | Not specified | COMPLETED | EASYX-1 : A Multicenter Study on Safety and Efficacy of Easyx Liquid Embolization Agent Used in Five Separate Indications |
| NCT03540056 | Not specified | UNKNOWN | Testicular Growth During Puberty in Boys With and Without a Left-sided Varicocele |
| NCT04397887 | Not specified | COMPLETED | Seminal TEX101 as a Predictor of Recovery of Spermatogenesis in Azoospermic Men With Palpable Varicocele |
| NCT04509869 | Not specified | COMPLETED | Outcome of Varicocelectomy on Normal Semen in Patients Complaining of Orchialgia |
| NCT04856579 | Not specified | COMPLETED | Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele |
| NCT05034406 | Not specified | COMPLETED | The Effect of Subcutaneous and Intraperitoneal Anesthesia on Post Laparoscopic Pain |
| NCT05171504 | Not specified | UNKNOWN | Lactoferrin and Iron in Seminal Plasma of Varicocele |
| NCT05330533 | Not specified | UNKNOWN | Effect of Recent Ejaculation on Scrotal Duplex Parameters in Infertile Males With Varicocele |
| NCT05558748 | Not specified | UNKNOWN | Comparison of USG-Guided Caudal Versus Ilioinguinal/Iliohypogastric Nerve Block for Pediatric Inguinal Surgeries |
| NCT05617261 | Not specified | UNKNOWN | Evaluating Patient Tolerability and Success for Penile and Scrotal Urologic Procedures Under Conscious Sedation: A Prospective Study |
| NCT06509321 | Not specified | COMPLETED | Comparison Between Loupe-Assisted Varicocelectomy With Nitroglycerin Instillation and Microscopic Varicocelectomy |
| NCT07353164 | Not specified | COMPLETED | Comparison of Open Versus Laparoscopic High Ligation Varicocelectomy For The Treatment Of Varicocele |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| LEVOBUPIVACAINE | 4 | 1 |
Related Atlas pages
- Drugs: Levobupivacaine