Vascular hemostatic disease
disease diseaseOn this page
Also known as disorder, vascular hemostaticdisorders, vascular hemostatichemostatic disorderhemostatic disorder, vascularhemostatic disorders, vascularvascular hemostatic disordervascular hemostatic disorders
Summary
Vascular hemostatic disease (MONDO:0003159) is a disease and 21 clinical trials. Top therapeutic interventions include sodium chloride, recombinant human thrombopoietin, and taniraleucel. A subtype of hemorrhagic disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 21
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | vascular hemostatic disease |
| Mondo ID | MONDO:0003159 |
| MeSH | D020141 |
| DOID | DOID:484 |
| SNOMED CT | 21112004 |
| UMLS | C0600502 |
| MedGen | 154721 |
| GARD | 0023389 |
| Is cancer (heuristic) | no |
Also known as: disorder, vascular hemostatic · disorders, vascular hemostatic · hemostatic disorder · hemostatic disorder, vascular · hemostatic disorders, vascular · vascular hemostatic disorder · vascular hemostatic disorders
Disease family
This is a subtype of hemorrhagic disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › hematologic disorder › hemorrhagic disease › vascular hemostatic disease
Related subtypes (27): inherited bleeding disorder, platelet-type, factor VII deficiency, factor X deficiency, purpura, congenital factor V deficiency, congenital high-molecular-weight kininogen deficiency, congenital factor XII deficiency, alpha-2-plasmin inhibitor deficiency, hemophilia A, hemophilia B, East Texas bleeding disorder, congenital factor XI deficiency, inherited prekallikrein deficiency, congenital plasminogen activator inhibitor type 1 deficiency, thrombomodulin-related bleeding disorder, congenital vitamin K-dependent coagulation factors deficiency, hemorrhagic disease due to alpha-1-antitrypsin Pittsburgh mutation, multiple sclerosis-ichthyosis-factor VIII deficiency syndrome, congenital factor XIII deficiency, congenital fibrinogen deficiency, combined deficiency of factor V and factor VIII, acquired hemophilia, fetal and neonatal alloimmune thrombocytopenia, hereditary von Willebrand disease, acquired von willebrand syndrome, prothrombin deficiency, hemophilia B leyden
Subtypes (2): Shwartzman phenomenon, cavernous hemangioma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated or in trials for this disease
1 approved drug — disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Status |
|---|---|
| Idecabtagene Vicleucel | Approved (phase 4) |
Clinical trials & evidence
Clinical trials
Clinical trials: 21.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 16 |
| PHASE1 | 3 |
| PHASE4 | 1 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01919840 | PHASE4 | TERMINATED | Blood Products Transfusion in Cardiac Surgery After the Implementation of a Coagulation Monitoring System at Patient Bedside: Thromboelastometry Versus Standard Transfusion Protocol |
| NCT03806556 | PHASE1/PHASE2 | TERMINATED | A Pediatric Trial Using Tranexamic Acid in Thrombocytopenia |
| NCT06271252 | PHASE1 | RECRUITING | A Study to Evaluate the Safety, PK/PD of (OriCAR-017) in Subjects With RR/MM - RIGEL Study |
| NCT07075185 | PHASE1 | RECRUITING | A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma |
| NCT04309084 | PHASE1 | UNKNOWN | Natural Killer Cell (CYNK-001) Infusions in Adults With Multiple Myeloma |
| NCT06242353 | Not specified | NOT_YET_RECRUITING | Coagulopathy in Childhood Acute Lymphoblastic Leukaemia |
| NCT06328647 | Not specified | ACTIVE_NOT_RECRUITING | Quantra Point-of-Care Hemostasis Monitoring |
| NCT06571552 | Not specified | RECRUITING | Coagulation Disorders Secondary to Two Plasmapheresis Techniques (Double Filtration Plasmapheresis vs. PFS). Descriptive Pilot Study. |
| NCT02281240 | Not specified | UNKNOWN | Hemostatic Complications in Hematopoietic Stem Cell Transplantation |
| NCT03281252 | Not specified | UNKNOWN | A Prospective Study of Evaluation of Minor Bleeding and Utility of Bleeding Criteria in Acute-on-chronic Liver Failure Patients in China |
| NCT03555383 | Not specified | COMPLETED | Individualized Multimodal Hemostasis Evaluation Pyramid (IMHOTEP) |
| NCT03756948 | Not specified | COMPLETED | Viscoelastic Tests-Guided Therapy In Liver Transplantation |
| NCT04179357 | Not specified | UNKNOWN | Hemostatic Disorders on Intensive Care Patients. |
| NCT04499612 | Not specified | COMPLETED | Influence of Cardiac Implantable Electronic Devices on the Hemostatic System |
| NCT04600609 | Not specified | COMPLETED | Examining the Experiences of Children With Blood Disorders |
| NCT04650529 | Not specified | UNKNOWN | Gyeongsang National University Hospital Registry |
| NCT04729946 | Not specified | TERMINATED | Clinical and Urgent Colonoscopy Outcomes Using the Pure-Vu® Cleansing System |
| NCT04757285 | Not specified | COMPLETED | Copeptin and Psychological Stress of Medic During COVID-19 Pandemic |
| NCT04762576 | Not specified | UNKNOWN | Thrombin in Cardiac Surgery |
| NCT05476458 | Not specified | UNKNOWN | To Evaluate Efficacy of Red Dichromatic Imaging (RDI) in Achieving Hemostasis During POEM Using GF 1500 UGI Scope |
| NCT05775731 | Not specified | UNKNOWN | Markers of Inflammation and of the Pro-thrombotic State in Hospital Shift and Day Workers |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| SODIUM CHLORIDE | 4 | 1 |
| RECOMBINANT HUMAN THROMBOPOIETIN | 3 | 1 |
| TANIRALEUCEL | 1 | 1 |