Venous insufficiency

Summary

Venous insufficiency (MONDO:0000945) is a disease and 88 clinical trials. Top therapeutic interventions include diosmin, polidocanol, and gelatin. A subtype of vein disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 88

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	venous insufficiency
Mondo ID	MONDO:0000945
MeSH	D014689
DOID	DOID:10128
SNOMED CT	20696009
UMLS	C0042485
MedGen	21841
Anatomy (UBERON)	UBERON:0001638
Is cancer (heuristic)	no

Also known as: peripheral venous insufficiency · venous insufficiency · venous insufficiency (disease)

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of vein disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › vein disorder › venous insufficiency

Related subtypes (12): portal vein thrombosis, occlusion of tributary of retinal vein, central retinal vein occlusion, cavernous sinus meningioma, superior vena cava angiosarcoma, pulmonary vein leiomyosarcoma, phlebitis, malignant jugulotympanic paraganglioma, varicose disease, vein of Galen aneurysm, isolated splenic vein thrombosis, isolated mesenteric vein thrombosis

Subtypes (2): chronic venous insufficiency, post-thrombotic syndrome

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 2 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Diosmin	Phase 3 (in late-stage trials)
Polidocanol	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 88.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	61
PHASE3	8
PHASE2	8
PHASE4	6
PHASE1/PHASE2	3
PHASE2/PHASE3	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00835822	PHASE4	COMPLETED	Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency
NCT01458795	PHASE4	COMPLETED	The Fate Of Calf Perforators After Endovenous Laser Ablation Of Saphenous Veins
NCT02184234	PHASE4	COMPLETED	Tolerability of Antistax® in Patients Suffering From Chronic Venous Insufficiency (CVI)
NCT02621632	PHASE4	COMPLETED	SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device
NCT02929056	PHASE4	TERMINATED	Amniotic Membrane Allograft Application in the Management of Venous Leg Ulcerations
NCT03471910	PHASE4	COMPLETED	Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency
NCT07432529	PHASE3	NOT_YET_RECRUITING	Design and Rationale of the COLT Study
NCT00196443	PHASE2/PHASE3	COMPLETED	The Influence of Compression Stockings on Skin’s Barrier Function at Patients With Chronic Venous Disease
NCT00292435	PHASE3	COMPLETED	Efficacy and Tolerability CVI (A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial (CVI)
NCT00348764	PHASE3	COMPLETED	ESGVS: Sclerotherapy With Lauromacrogol
NCT00838500	PHASE3	COMPLETED	THERMES ET VEINES: Spa for Prevention of Leg Ulcers
NCT00855179	PHASE3	COMPLETED	Assess the Efficacy and Tolerability of Antistax Film-coated Tablets in Patients With Chronic Venous Insufficiency
NCT01110512	PHASE3	UNKNOWN	Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI)
NCT02191254	PHASE3	COMPLETED	Efficacy and Tolerability of Antistax® in Male and Female Patients Suffering From Chronic Venous Insufficiency
NCT02211898	PHASE3	COMPLETED	Clinical Study of BNS003 on Swelling in Legs Due to Venous Reflux
NCT00013273	PHASE2	COMPLETED	Physical Conditioning in Management of Chronic Venous Insufficiency
NCT00310752	PHASE1/PHASE2	COMPLETED	Evaluation of DermStream(tm) - an Irrigation Product for Chronic Wound Management
NCT00732823	PHASE2	COMPLETED	Compression Device Safety Study
NCT01509599	PHASE1/PHASE2	COMPLETED	Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation
NCT01972633	PHASE1/PHASE2	UNKNOWN	Endoluminale Obliteration Der Stammvene Mit Dem 1470nm Laser Versus VNUS Closure Fast
NCT02191163	PHASE2	COMPLETED	Efficacy of Antistax® in Improving Microcirculation of the Skin in the Leg in Patients Suffering From Chronic Venous Insufficiency
NCT02191280	PHASE2	COMPLETED	Antistax® in Patients With Chronic Venous Insufficiency
NCT02483962	PHASE2	COMPLETED	Venavine Intensive® in the Treatment of Symptoms Associated With Chronic Venous Insufficiency
NCT02498327	PHASE2	COMPLETED	The Efficacy of Venavine Intensive® on the Quality of Life in Females With Chronic Venous Insufficiency
NCT02626156	PHASE2	COMPLETED	Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence
NCT03311269	PHASE2	TERMINATED	A Study Evaluating ClariVein With a Sclerosing Agent for the Treatment of Venous Insufficiency
NCT00720239	EARLY_PHASE1	COMPLETED	Taliderm Dressing for Venous Ulcers
NCT02397226	Not specified	ACTIVE_NOT_RECRUITING	Lower Limb Venous Insufficiency and the Effect of Radiofrequency Treatment Versus Open Surgery
NCT03250247	Not specified	ACTIVE_NOT_RECRUITING	Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial)
NCT04546750	Not specified	RECRUITING	Prospective Cohort Study for Varicose Veins Incidence and Natural Course
NCT06350695	Not specified	RECRUITING	The ROle of Compression StocKings in Heart Failure Patients
NCT06811909	Not specified	RECRUITING	Non-healing Venous Leg Ulcers Treated With Standard Care With or Without BR-AC
NCT07123285	Not specified	NOT_YET_RECRUITING	Effect of Photobiomodulation on Healing of Venous Leg Ulcers
NCT07577141	Not specified	NOT_YET_RECRUITING	Impact of Chronic Venous Insufficiency on Outcomes After Total Knee Arthroplasty
NCT07603076	Not specified	NOT_YET_RECRUITING	Assessment of Venous Insufficiency and Clinical Features in Lipedema
NCT00270972	Not specified	UNKNOWN	The Evaluation of OrCel for the Treatment of Venous Ulcers
NCT00395265	Not specified	COMPLETED	Evaluating the Relationship Between Blood Clotting Disorders, Inflammation, and Obesity in Individuals With Venous Disorders and Post-Thrombotic Syndrome
NCT00565604	Not specified	COMPLETED	Safety and Efficacy of Endovenous Laser Ablation for the Resolution of Incompetent Perforator Veins
NCT00617825	Not specified	COMPLETED	Feasibility Study of Cryotherapy for Chronic Venous Disorders
NCT00670540	Not specified	COMPLETED	Epidemiology of Thromboembolism Disease: A Cohort Study

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DIOSMIN	4	2
POLIDOCANOL	4	2
GELATIN	3	2
HESPERIDIN	3	1
CHEMBL3039392	0	1
CHEMBL1231723	0	1