Vertebral artery dissection

Summary

Vertebral artery dissection (MONDO:1040011) is a disease and 3 clinical trials. Top therapeutic interventions include dipyridamole. A subtype of cervical artery dissection — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 3

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	vertebral artery dissection
Mondo ID	MONDO:1040011
Orphanet	689001
UMLS	C0338586
MedGen	137904
GARD	0027438
Is cancer (heuristic)	no

Also known as: VAD

Disease family

This is a subtype of cervical artery dissection. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › arterial disorder › cervical artery dissection › vertebral artery dissection

Related subtypes (1): familial cervical artery dissection

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00238667	PHASE3	COMPLETED	To Determine the Feasibility of a Clinical Trial Comparing Anticoagulants Versus Antiplatelets in the Acute Treatment of Patients With Cervical Artery Dissection
NCT01205490	Not specified	UNKNOWN	Changes in Cerebral Blood Flow With Spinal Manipulative Therapy vs. Voluntary Motion
NCT02667821	Not specified	COMPLETED	Vertebral Artery and Cerebral Hemodynamics After Various Head Positions & Manipulation in Patients With Neck Pain

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DIPYRIDAMOLE	4	1